Antiulcer Drugs and Interactions

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Questions and Answers

What is a consideration when taking antacids?

Take only once a week

Take with meals to enhance absorption

Take a small amount of fluid to ensure the drug reaches the stomach (correct)

Take within 1 hour before and 2 hours after other medications

What is a side effect of aluminum-based antacids?

Constipation (correct)

Diarrhea

Electrolyte imbalance

Nausea

What is the mechanism of action of histamine 2 blockers?

Blocking histamine at H2 receptors of parietal cells in the stomach (correct)

Inhibiting the production of gastric acid

Enhancing the production of gastric acid

Stimulating the production of histamine

What is a contraindication for the use of famotidine?

All of the above Signup and view all the answers

What is the action of proton pump inhibitors?

Reducing gastric acid by inhibiting the hydrogen/potassium ATPase enzyme Signup and view all the answers

What is a nursing intervention when taking antacids?

Notify the HCP if constipation or diarrhea occurs Signup and view all the answers

What is an assessment parameter for patients taking antiulcer drugs?

Pain, renal function, and medication history Signup and view all the answers

What is a lifestyle modification for patients taking antiulcer drugs?

Talk to the HCP about stress control measures Signup and view all the answers

What is the primary mechanism of action of sucralfate?

Coats the gastric lining Signup and view all the answers

What is a key instruction for patients taking sucralfate?

Administer on empty stomach Signup and view all the answers

Which of the following is a potential interaction with proton pump inhibitors like pantoprazole?

Taking with food Signup and view all the answers

What is the purpose of the Meretek UBT test?

To detect the presence of H.pylori Signup and view all the answers

What is an alternative to endoscopy and biopsy for detecting H.pylori?

Meretek UBT breath test Signup and view all the answers

What is a common side effect of pepsin inhibitors like sucralfate?

Drowsiness and constipation Signup and view all the answers

What is the effectiveness of the Meretek UBT breath test in detecting H.pylori?

90% to 95% Signup and view all the answers

What is a key lifestyle modification for patients taking antiulcer drugs?

Avoiding foods that cause irritation Signup and view all the answers

What is the role of urease in the Meretek UBT breath test?

To hydrolyze the urea Signup and view all the answers

What is a contraindication for proton pump inhibitors like pantoprazole?

Pregnancy and breast feeding Signup and view all the answers

What is a key assessment for patients taking antiulcer drugs?

Pain assessment and GI status Signup and view all the answers

What is the purpose of a serology test in relation to H.pylori?

To check for antibodies to H.pylori Signup and view all the answers

What is the mechanism of action of sucralfate?

Forms a viscous substance that coats the ulcer Signup and view all the answers

What is the action of pepsin inhibitors like sucralfate?

Forming a protective paste to cover the ulcer Signup and view all the answers

What is a key intervention for patients taking sucralfate?

Increase fluids and bulk to prevent constipation Signup and view all the answers

What is the benefit of using sucralfate over antacids?

It coats the gastric lining, protecting it from acid and pepsin Signup and view all the answers

Which of the following is a lifestyle modification for patients with peptic ulcers?

Sit upright after meals Signup and view all the answers

What is a common cause of gastroesophageal reflux disease (GERD)?

An incompetent lower esophageal sphincter Signup and view all the answers

Which type of medication is used to reduce acid production in the stomach?

H2 blockers Signup and view all the answers

What is the primary mechanism of action of proton pump inhibitors?

Reducing acid production Signup and view all the answers

What is the primary role of gastroprotective agents?

Protecting the mucosal lining Signup and view all the answers

What is a common symptom of peptic ulcers?

Gnawing, aching pain after eating Signup and view all the answers

Which of the following is a predisposing factor for peptic ulcers?

All of the above Signup and view all the answers

What is the primary goal of antacids in treating peptic ulcers?

Neutralizing stomach acid Signup and view all the answers

What is the primary reason for encouraging fluid intake in patients with peptic ulcer disease?

To prevent constipation and dry mouth Signup and view all the answers

What is the correct timing for taking sucralfate in relation to meals?

30 minutes before meals Signup and view all the answers

What is the primary purpose of antacids in the treatment of peptic ulcer disease?

To neutralize stomach acid Signup and view all the answers

What is the anticipated treatment for a patient with H. pylori and peptic ulcer disease?

Proton pump inhibitors and antibiotics Signup and view all the answers

What is the potential complication of taking aluminum hydroxide on a daily basis to relieve symptoms of GERD?

Constipation Signup and view all the answers

What is the purpose of taking Maalox in relation to sucralfate (Carafate)?

To take 30 minutes before sucralfate Signup and view all the answers

Why is it important for a patient with peptic ulcer disease to report pain or vomiting of blood?

To monitor for signs of complications Signup and view all the answers

What is the indication for taking sucralfate?

To treat peptic ulcer disease Signup and view all the answers

Study Notes

Antiulcer Drugs

Antiulcer drugs are used to treat peptic ulcers, GERD, and stress ulcers.
Examples of antiulcer drugs include antacids, histamine 2 blockers, proton pump inhibitors, and pepsin inhibitors.

Antacids

Examples of antacids include aluminum and magnesium.
Side effects of antacids include constipation (aluminum), diarrhea (magnesium), and electrolyte imbalance.
Take antacids with a small amount of fluid to ensure the drug reaches the stomach.
Do not take antacids within 1 hour before or 2 hours after taking other medications.

Histamine 2 Blockers

Examples of histamine 2 blockers include famotidine.
Action: reduce gastric acid by blocking histamine at H2 receptors in parietal cells in the stomach.
Uses: prevent and treat peptic ulcers, GERD, and stress ulcers.
Side effects: confusion, headaches, dizziness, diarrhea, constipation, nausea, rash, blurred vision, malaise, and decreased libido.
Adverse reactions: hepatotoxicity, cardiac dysrhythmias, and blood dyscrasias.
Contraindications: pregnancy, breastfeeding, and severe renal or liver disease.

Proton Pump Inhibitors

Examples of proton pump inhibitors include pantoprazole.
Action: reduce gastric acid by inhibiting hydrogen/potassium ATPase enzyme in gastric parietal cells.
Uses: used in H. pylori treatment with antibiotics.
Side effects: headache, insomnia, dizziness, dry mouth, and GI distress.
Contraindications: allergic reactions, pregnancy, and breastfeeding.
Interactions: take on an empty stomach as food can decrease effectiveness; take 30 minutes before other medications.

Pepsin Inhibitors

Examples of pepsin inhibitors include sucralfate.
Action: combines with gastric acid to form a thick paste that covers the ulcer, protecting it from acid and pepsin.
Side effects: drowsiness, constipation, GI distress, and hyperglycemia.
Contraindications: renal failure.
Interactions: other drugs may not be absorbed, give 1-2 hours around other drugs.

Assessment and Interventions

Assess pain, GI status, and renal function.
Interventions: take medications as directed, avoid smoking, avoid driving until the effect is known, eat food rich in Vitamin B12, and avoid foods that cause irritation.
Increase fluids, bulk, and exercise to prevent constipation.
Stop smoking and encourage a healthy diet.

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Description

Learn about antiulcer drugs, their contraindications, interactions with other drugs, side effects, and assessment of pain and electrolyte imbalance.