Questions and Answers
What is the class of CIMETIDINE?
What is the mechanism of action of CIMETIDINE?
Competitively inhibits action of histamine at the H2 receptor sites of parietal cells, decreasing gastric acid secretion.
CIMETIDINE is indicated for the treatment of ______.
short-term treatment of duodenal ulcer; maintenance therapy, pathological hypersecretory conditions, prevention of upper GI bleeding.
Hypersensitivity to CIMETIDINE is a contraindication.
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What are common adverse reactions of CIMETIDINE?
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What drugs does CIMETIDINE interact with?
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What is the adult dosage for pathological hypersecretory conditions?
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CIMETIDINE can be utilized in children younger than 16 years.
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What route of administration is used for CIMETIDINE?
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The onset of action of CIMETIDINE is ______.
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What should be monitored in patients using CIMETIDINE?
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Study Notes
Drug Profile for Cimetidine
- Class: GI-Anti Ulcer
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Mechanism of Action:
- Competitively inhibits histamine at H2 receptor sites in parietal cells.
- Leads to decreased gastric acid secretion.
Indications and Field Use
- Primarily for infusion monitoring during interfacility transport.
- Short-term treatment of duodenal ulcers and maintenance therapy.
- Addresses pathological hypersecretory conditions.
- Prevents upper GI bleeding.
Contraindications
- Contraindicated in individuals with hypersensitivity to the drug.
Adverse Reactions
- Gastrointestinal: Mild and transient diarrhea.
- Cardiac: Potential heart block observed in elderly patients.
Incompatibilities/Drug Interactions
- Drugs affected include:
- Inhibits hepatic microsomal enzyme metabolism: Fosphenytoin, lidocaine, phenytoin, propranolol, some benzodiazepines, theophylline, warfarin.
- Decreases drug absorption: Digoxin, fluconazole, indomethacin, iron salts, ketoconazole, tetracycline.
Adult Dosage
- Pathologic hypersecretory conditions: 300 mg in 50 mL normal saline, infused over 30 minutes.
- Prevention of upper GI bleeding: Continuous infusion at 50 mg/hour.
Pediatric Dosage
- Approved for use in children aged 16 years or older.
Routes of Administration
- Administered via IV infusion, typically as a piggyback setup.
Onset of Action
- The exact onset of action is unknown.
Peak Effects
- Effects are observed immediately after administration.
Duration of Action
- Duration of action is not clearly defined.
Drug Box Minimum Supply
- No minimum supply is required for inclusion in a drug box.
Special Notes
- Exercise caution in elderly or debilitated patients due to increased risk of confusion.
- Monitor for signs of abdominal pain and check for blood in emesis, stool, or gastric aspirate.
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Description
These flashcards provide essential information about Cimetidine, including its classification as a GI anti-ulcer drug, its mechanism of action, and indications for use. Ideal for medical students and healthcare professionals preparing for examinations or reviewing pharmacology concepts.
