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Questions and Answers
What is the primary mechanism of action of metronidazole against anaerobic bacteria?
What is the primary mechanism of action of metronidazole against anaerobic bacteria?
- Damaging microbial DNA (correct)
- Inhibiting protein synthesis
- Inhibiting cell wall synthesis
- Disrupting membrane function
Which of the following is NOT a characteristic of metronidazole's pharmacokinetics?
Which of the following is NOT a characteristic of metronidazole's pharmacokinetics?
- Poorly bound to plasma proteins
- Diffuses well into the tissues including brain
- Well absorbed after oral administration
- Extensively metabolized in the brain (correct)
Why is metronidazole ineffective against aerobic bacteria?
Why is metronidazole ineffective against aerobic bacteria?
- It cannot be reduced to its active metabolite in the presence of oxygen (correct)
- It is not metabolized in the liver
- It is unable to diffuse into the tissues
- It is not absorbed after oral administration
What is the name of the group of antimicrobials that includes metronidazole, tinidazole, and secnidazole?
What is the name of the group of antimicrobials that includes metronidazole, tinidazole, and secnidazole?
What is the effect of metronidazole on microbial DNA?
What is the effect of metronidazole on microbial DNA?
What is a common side effect of metronidazole in the gastrointestinal system?
What is a common side effect of metronidazole in the gastrointestinal system?
What is the primary route of excretion for metronidazole metabolites?
What is the primary route of excretion for metronidazole metabolites?
What is the interaction between metronidazole and warfarin?
What is the interaction between metronidazole and warfarin?
Why should metronidazole be avoided in pregnant women?
Why should metronidazole be avoided in pregnant women?
What is the dose of metronidazole used to treat Vincent's angina?
What is the dose of metronidazole used to treat Vincent's angina?
What is the effect of metronidazole on lithium?
What is the effect of metronidazole on lithium?
What is the disulfiram-like reaction caused by?
What is the disulfiram-like reaction caused by?
What is the primary use of metronidazole in the treatment of alveolar abscess?
What is the primary use of metronidazole in the treatment of alveolar abscess?
Which antibiotic is used in combination with metronidazole for the treatment of anaerobic brain abscess?
Which antibiotic is used in combination with metronidazole for the treatment of anaerobic brain abscess?
What is the advantage of metronidazole over vancomycin in the treatment of antibiotic-associated pseudomembranous colitis?
What is the advantage of metronidazole over vancomycin in the treatment of antibiotic-associated pseudomembranous colitis?
What is the recommended treatment duration for metronidazole in the treatment of amoebiasis?
What is the recommended treatment duration for metronidazole in the treatment of amoebiasis?
What is the difference between tinidazole and metronidazole?
What is the difference between tinidazole and metronidazole?
Which fluoroquinolone is the prototype drug?
Which fluoroquinolone is the prototype drug?
What type of bacteria is Ciprofloxacin highly effective against?
What type of bacteria is Ciprofloxacin highly effective against?
Which of the following anaerobes is resistant to Ciprofloxacin?
Which of the following anaerobes is resistant to Ciprofloxacin?
What is the main route of excretion for Ciprofloxacin?
What is the main route of excretion for Ciprofloxacin?
What is a common adverse effect of Ciprofloxacin related to the GI tract?
What is a common adverse effect of Ciprofloxacin related to the GI tract?
Which of the following fluoroquinolones has increased activity against S. pneumoniae?
Which of the following fluoroquinolones has increased activity against S. pneumoniae?
What is the significance of food on Ciprofloxacin absorption?
What is the significance of food on Ciprofloxacin absorption?
What is the mechanism of action of metronidazole?
What is the mechanism of action of metronidazole?
Which of the following is a therapeutic use of metronidazole in medicine?
Which of the following is a therapeutic use of metronidazole in medicine?
What is a common adverse reaction of metronidazole?
What is a common adverse reaction of metronidazole?
Why should patients avoid alcohol while taking metronidazole?
Why should patients avoid alcohol while taking metronidazole?
What is a significant drug interaction of metronidazole?
What is a significant drug interaction of metronidazole?
Why should metronidazole be avoided in pregnant women?
Why should metronidazole be avoided in pregnant women?
