Podcast
Questions and Answers
Where are protein antigens of microbes mainly captured in the body?
Where are protein antigens of microbes mainly captured in the body?
- In the gastrointestinal tract
- In the primary lymphoid organs
- In the connective tissues and organs (correct)
- In the blood vessels
How do dendritic cells transport microbial antigens to lymph nodes?
How do dendritic cells transport microbial antigens to lymph nodes?
- By passive transport through the bloodstream
- By ingestion of antigens and migration to lymph nodes (correct)
- Through the respiratory tract
- By direct diffusion through the skin
Why is it impossible for lymphocytes to efficiently patrol all infected sites for foreign invaders?
Why is it impossible for lymphocytes to efficiently patrol all infected sites for foreign invaders?
- Due to the vast surface area of the lymphoid organs
- Because of the large volume of blood and connective tissues (correct)
- Because lymphocytes lack specificities for foreign invaders
- Because antigens are concentrated in the secondary lymphoid organs
What is the main function of dendritic cells in capturing microbial antigens?
What is the main function of dendritic cells in capturing microbial antigens?
What is the main function of dendritic cells in secondary lymphoid organs?
What is the main function of dendritic cells in secondary lymphoid organs?
Where are plasmacytoid dendritic cells primarily located?
Where are plasmacytoid dendritic cells primarily located?
How do dendritic cells capture microbes or their antigens?
How do dendritic cells capture microbes or their antigens?
What is the role of products of microbes in activating innate immune reactions?
What is the role of products of microbes in activating innate immune reactions?
What is the function of conventional subset dendritic cells in tissues and lymphoid organs?
What is the function of conventional subset dendritic cells in tissues and lymphoid organs?
What characterizes plasmacytoid dendritic cells based on their morphology?
What characterizes plasmacytoid dendritic cells based on their morphology?
What type of receptors do dendritic cells use to bind microbes or their antigens?
What type of receptors do dendritic cells use to bind microbes or their antigens?
What stimulates innate immune reactions in dendritic cells, tissue epithelial cells, and tissue-resident macrophages?
What stimulates innate immune reactions in dendritic cells, tissue epithelial cells, and tissue-resident macrophages?
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Study Notes
Antigen Capture and Presentation
- Protein antigens of microbes are mainly captured in the body by dendritic cells in peripheral tissues.
Dendritic Cell Functions
- Dendritic cells transport microbial antigens to lymph nodes, where they activate T-cells.
- The main function of dendritic cells in capturing microbial antigens is to process and present them to T-cells.
- In secondary lymphoid organs, dendritic cells activate T-cells and initiate an immune response.
Dendritic Cell Subsets
- Plasmacytoid dendritic cells are primarily located in peripheral tissues and lymphoid organs.
- Conventional subset dendritic cells are found in tissues and lymphoid organs, where they capture and process microbial antigens.
Antigen Capture Mechanisms
- Dendritic cells capture microbes or their antigens through receptors such as Toll-like receptors (TLRs) and C-type lectin receptors.
- These receptors recognize pathogen-associated molecular patterns (PAMPs) on microbial surfaces.
Innate Immune Reactions
- Products of microbes, such as lipopolysaccharides, stimulate innate immune reactions in dendritic cells, tissue epithelial cells, and tissue-resident macrophages.
- This stimulation activates the production of pro-inflammatory cytokines and type I interferons.
Dendritic Cell Morphology
- Plasmacytoid dendritic cells are characterized by their plasma cell-like morphology.
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