Antifungal Drugs - Fluconazole (Diflucan) Flashcards
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Questions and Answers

What is the drug class of fluconazole?

  • Antifungal (correct)
  • Antibacterial
  • Antiviral
  • Analgesic
  • What is the trade name of fluconazole?

    Diflucan

    What is the pregnancy category of fluconazole?

  • A
  • B
  • C (correct)
  • D
  • What is a contraindication for fluconazole?

    <p>Hypersensitivity</p> Signup and view all the answers

    What interactions does fluconazole have with warfarin?

    <p>Increases PT</p> Signup and view all the answers

    How is fluconazole absorbed in the body?

    <p>Well absorbed in GI tract</p> Signup and view all the answers

    What is the half-life of fluconazole?

    <p>20-50 hours</p> Signup and view all the answers

    What is one of the therapeutic uses of fluconazole?

    <p>To treat Candida infections</p> Signup and view all the answers

    What are some common side effects of fluconazole?

    <p>All of the above</p> Signup and view all the answers

    What is the nursing process reference page for fluconazole?

    <p>444-445</p> Signup and view all the answers

    Study Notes

    Antifungal Drug Overview: Fluconazole (Diflucan)

    • Drug Class: Antifungal, utilized to combat fungal infections.
    • Trade Name: Marketed as Diflucan.

    Pregnancy and Safety

    • Pregnancy Category: Classified as C, indicating potential risks to fetal development.

    Contraindications and Cautions

    • Hypersensitivity: Not safe for individuals with known allergies to fluconazole.
    • Caution advised during pregnancy, necessitating careful consideration of risks versus benefits.

    Drug Interactions

    • Increases Prothrombin Time (PT) when co-administered with warfarin.
    • Can enhance hypoglycemic effects when taken alongside oral sulfonylureas.
    • Interacts with phenytoin, cyclosporine, and haloperidol, elevating their plasma levels.
    • Effectiveness may decrease with concomitant use of cimetidine and rifampin.

    Pharmacokinetics

    • Absorption: Well-absorbed when administered orally via the gastrointestinal tract.
    • Distribution: Protein binding (PB) is approximately 12%.
    • Half-life (t1/2): Ranges from 20 to 50 hours, indicating prolonged action.
    • Excretion: Primarily eliminated through urine.

    Pharmacodynamics

    • Oral Administration:
      • Onset of action: Unknown.
      • Peak effect: 1-2 hours post-administration.
      • Duration of action: Unknown.
    • Vaginal Administration:
      • Onset, peak, and duration of action are all unknown.

    Therapeutic Applications

    • Indicated for the treatment of Candida infections and cryptococcal meningitis.
    • Mechanism of Action: Works by increasing permeability of fungal cell membranes, disrupting their integrity.

    Side Effects

    • Common side effects (oral):
      • Anorexia, nausea, vomiting, diarrhea (especially at large doses).
      • Additional symptoms include stomach cramps, rash, and headache.
    • Vaginal use may cause rash and burning sensation.
    • No known adverse reactions are associated with fluconazole.

    Nursing Considerations

    • Important information and guidelines for nursing care located on pages 444-445 of relevant pharmacological resources.

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    Description

    Explore key concepts of antifungal drugs with a focus on fluconazole, known as Diflucan. This quiz provides essential details about drug classification, interactions, and pregnancy category. Ideal for pharmacy students and healthcare professionals looking to enhance their knowledge of antifungal treatments.

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