Fluconazole Flashcards

Study Notes

Fluconazole Overview

Generic Name: Fluconazole
Trade Name: Diflucan
Classification: Azole Antifungal

Formulations Available

Tablets: 50mg, 100mg, 150mg, 200mg
Suspension: 10mg/ml, 40mg/ml
Injection: 2mg/ml

Mechanism of Action

Interferes with ergosterol formation, essential for fungal cell membranes.
Leads to fungal cell death by disrupting membrane function.

Therapeutic Uses

Treats cryptococcal meningitis, often in AIDS patients.
Effective against oropharyngeal and systemic candidiasis.
Used for vaginal candidiasis.

Contraindications

Not suitable for individuals with hypersensitivity to fluconazole or other azole antifungals.
Contraindicated during lactation.

Adverse Effects

Common side effects include headache, nausea, vomiting, and abdominal pain.
Potential for diarrhea and rash.
Increased AST levels in patients with cryptococcal meningitis and AIDS.

Nursing Implications

Monitor for allergic reactions, especially in patients with allergies to other antifungals.
Regularly check BUN, serum creatinine, and liver function tests due to possible hepatotoxicity.
Elevated lab values may include ALT, AST, alkaline phosphatase, and bilirubin.
Educate patients, especially those with diabetes, to monitor glycemic control.
Advise patients to inform healthcare providers of all medications being taken.

Description

Test your knowledge with these flashcards on Fluconazole. Covering its generic and trade names, classifications, availability, and action mechanisms, this quiz is perfect for students and professionals in medicine and pharmacy. Boost your understanding of this important antifungal medication.