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Questions and Answers
What is the MOA of Fluconazole (Diflucan)?
What is the MOA of Fluconazole (Diflucan)?
Inhibits synthesis of ergosterol in cell membrane.
When do you give Fluconazole (Diflucan)?
When do you give Fluconazole (Diflucan)?
Treatment of candidiasis, fungal meningitis.
When do you give a one-time dose of Fluconazole (Diflucan)?
When do you give a one-time dose of Fluconazole (Diflucan)?
Vaginal yeast infection.
What is Fluconazole (Diflucan) an alternative to?
What is Fluconazole (Diflucan) an alternative to?
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What are the advantages of Fluconazole (Diflucan)?
What are the advantages of Fluconazole (Diflucan)?
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What are the adverse effects of Fluconazole (Diflucan)?
What are the adverse effects of Fluconazole (Diflucan)?
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What are the serious adverse effects of Fluconazole (Diflucan)?
What are the serious adverse effects of Fluconazole (Diflucan)?
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When do you not give Fluconazole (Diflucan)?
When do you not give Fluconazole (Diflucan)?
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What do you monitor with Fluconazole (Diflucan)?
What do you monitor with Fluconazole (Diflucan)?
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Study Notes
Mechanism of Action
- Fluconazole inhibits ergosterol synthesis, an essential component of fungal cell membranes.
Clinical Indications
- Effective in treating candidiasis and fungal meningitis.
- A single dose is indicated for vaginal yeast infections.
Alternative Treatment
- Serves as an alternative to intravenous amphotericin for fungal infections.
Advantages
- Lower toxicity compared to some antifungal agents.
- Available in oral form for usability, facilitating administration.
Adverse Effects
- Common side effects include nausea, vomiting, and diarrhea.
Serious Adverse Effects
- May cause Steven-Johnson syndrome, a severe skin reaction.
Contraindications
- Not recommended for patients with hepatic impairment, hypokalemia, or preexisting renal impairment.
- Caution in patients due to CYP450 drug interactions.
Monitoring Parameters
- Regular monitoring of blood urea nitrogen (BUN), serum creatinine, and liver function tests is essential during Fluconazole therapy.
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Description
Test your knowledge on Fluconazole (Diflucan) with this set of flashcards. Learn about its mechanism of action, indications for use, and specific situations for dosing. Perfect for pharmacy students or healthcare professionals seeking to refresh their understanding of this antifungal medication.
