21 Questions
What is the primary goal of treatment in epilepsy?
Preventing the occurrence of seizures
What is the mechanism of action of Phenytoin?
Use-dependent block of sodium channels
What is the primary indication for Gabapentin in epilepsy treatment?
Focal seizures
What is the auxiliary subunit of voltage-gated P/Q type calcium channels that Gabapentin binds to?
a2d protein
What is a common side effect of long-term Phenytoin use?
Gingival hyperplasia
What is the term used to describe patients who do not achieve control with two or more antiepileptic drugs?
Pharmacoresistant
What percentage of patients with epilepsy have their seizures completely controlled with optimal drug therapy?
66%
What is the approximate percentage of the population affected by epilepsy?
1%
What is the primary cause of seizures in epilepsy?
Asynchronous high frequency discharge of a group of neurons
What is the approximate percentage of epilepsy cases that are familial and involve genetic mutations?
33%
What is the typical duration of antiepileptic drug therapy for patients with epilepsy?
Many years
What is the primary goal of treatment in Parkinson's disease?
Restore dopamine receptor function
What is the typical duration of therapy for epilepsy?
At least 2 years
What is the male to female ratio of Parkinson's disease incidence?
2:1
What is the percentage of striatal dopamine that must be lost before symptoms of Parkinson's disease appear?
20-40%
What is the effect of dopamine on cholinergic neurons in the normal brain?
Inhibitory
What is the first line treatment for Parkinson's disease?
Levodopa
What is the percentage of patients who show marked initial improvement with levodopa therapy?
80%
What is the major limitation of levodopa therapy?
It does not arrest or reverse neuronal degeneration
What is the mechanism of action of trihexyphenidyl?
Cholinergic receptor antagonist
What is the 'on-off' effect seen in patients on long-term levodopa therapy?
Fluctuations in clinical response to levodopa
Test your knowledge on antiepileptic and antiparkinson's drugs, their uses, and effects. Learn about the treatment of epilepsy and non-epileptic disorders, and how optimal drug therapy can control seizures. Review the nature of epilepsy and its characterization.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
