Antiepileptic and Antiparkinson's Drugs Quiz
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Questions and Answers

What is the primary goal of treatment in epilepsy?

  • Enhancing fast GABA mediated synaptic inhibition
  • Preventing the occurrence of seizures (correct)
  • Correcting the underlying cause of the disorder
  • Modifying the electrical properties of affected cells

    • What is the mechanism of action of Phenytoin?

  • Inhibiting voltage-gated calcium channels
  • Use-dependent block of sodium channels (correct)
  • Modifying synaptic release processes
  • Enhancing fast GABA mediated synaptic inhibition

    • What is the primary indication for Gabapentin in epilepsy treatment?

  • Myoclonic seizures
  • Absence seizures
  • Tonic-clonic seizures
  • Focal seizures (correct)

    • What is the auxiliary subunit of voltage-gated P/Q type calcium channels that Gabapentin binds to?

    <p>a2d protein</p> Signup and view all the answers

    What is a common side effect of long-term Phenytoin use?

    <p>Gingival hyperplasia</p> Signup and view all the answers

    What is the term used to describe patients who do not achieve control with two or more antiepileptic drugs?

    <p>Pharmacoresistant</p> Signup and view all the answers

    What percentage of patients with epilepsy have their seizures completely controlled with optimal drug therapy?

    <p>66%</p> Signup and view all the answers

    What is the approximate percentage of the population affected by epilepsy?

    <p>1%</p> Signup and view all the answers

    What is the primary cause of seizures in epilepsy?

    <p>Asynchronous high frequency discharge of a group of neurons</p> Signup and view all the answers

    What is the approximate percentage of epilepsy cases that are familial and involve genetic mutations?

    <p>33%</p> Signup and view all the answers

    What is the typical duration of antiepileptic drug therapy for patients with epilepsy?

    <p>Many years</p> Signup and view all the answers

    What is the primary goal of treatment in Parkinson's disease?

    <p>Restore dopamine receptor function</p> Signup and view all the answers

    What is the typical duration of therapy for epilepsy?

    <p>At least 2 years</p> Signup and view all the answers

    What is the male to female ratio of Parkinson's disease incidence?

    <p>2:1</p> Signup and view all the answers

    What is the percentage of striatal dopamine that must be lost before symptoms of Parkinson's disease appear?

    <p>20-40%</p> Signup and view all the answers

    What is the effect of dopamine on cholinergic neurons in the normal brain?

    <p>Inhibitory</p> Signup and view all the answers

    What is the first line treatment for Parkinson's disease?

    <p>Levodopa</p> Signup and view all the answers

    What is the percentage of patients who show marked initial improvement with levodopa therapy?

    <p>80%</p> Signup and view all the answers

    What is the major limitation of levodopa therapy?

    <p>It does not arrest or reverse neuronal degeneration</p> Signup and view all the answers

    What is the mechanism of action of trihexyphenidyl?

    <p>Cholinergic receptor antagonist</p> Signup and view all the answers

    What is the 'on-off' effect seen in patients on long-term levodopa therapy?

    <p>Fluctuations in clinical response to levodopa</p> Signup and view all the answers

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