Antibodies and Tissue Injury

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Questions and Answers

Which cells release reactive oxygen species and lysosomal enzymes that damage adjacent tissues when activated at sites of antibody deposition?

  • Macrophages
  • Erythrocytes
  • Platelets
  • Neutrophils (correct)

Which type of antibodies activate the complement system by the classical pathway, resulting in the production of complement by-products that recruit leukocytes and induce inflammation?

  • IgG2 and IgG4
  • IgM and IgA
  • IgG1 and IgG3 (correct)
  • IgD and IgE

Which disease is caused by autoantibodies specific for a protein required for absorption of vitamin B12, resulting in a multisystem disease due to B12 deficiency?

  • Hyperthyroidism
  • Myasthenia gravis
  • Pernicious anemia (correct)
  • Graves disease

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