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Type II Hypersensitivity Quiz

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Questions and Answers

Which type of antibodies are involved in Type II hypersensitivity?

IgA and IgE

IgG and IgE

IgD and IgG

IgM and IgG (correct)

What is the mechanism of tissue damage in Type II hypersensitivity?

Activation of T-cells

Activation of complement system (correct)

Activation of B-cells

Activation of natural killer cells

What is an example of complement dependent Type II hypersensitivity?

Acute hemolytic transfusion reaction (correct)

Contact dermatitis

Anaphylactic shock

Allergic rhinitis

What is Type II hypersensitivity in the Gell and Coombs classification of allergic reactions?

An antibody mediated process Signup and view all the answers

What are the mechanisms involved in Type II hypersensitivity?

Complement activation, antibody-dependent cellular cytotoxicity, anti-receptor activity Signup and view all the answers

What is an example of Type II hypersensitivity?

Acute hemolytic transfusion reaction Signup and view all the answers

What is the mechanism of Type II hypersensitivity?

Antibody mediated process Signup and view all the answers

What is the time frame for the development of reactions in Type II hypersensitivity?

2-24 hours Signup and view all the answers

What is an example of antibody-dependent cellular cytotoxicity in Type II hypersensitivity?

Anti-receptor activity Signup and view all the answers

Which complement pathway is activated in complement dependent Type II hypersensitivity?

Classical complement pathway Signup and view all the answers

Which antibodies are directed against antigens in Type II hypersensitivity?

IgG and IgM Signup and view all the answers

What is the time frame for the development of reactions in Type II hypersensitivity?

Hours to days Signup and view all the answers

Study Notes

Type II Hypersensitivity

Involves IgG and IgM antibodies
Mechanism of tissue damage: antibodies bind to antigens on cell surfaces, leading to activation of complement system and destruction of cells

Mechanisms

Antibody-dependent cellular cytotoxicity (ADCC)
Complement-dependent cytotoxicity
Phagocytosis

Examples

Hemolytic disease of the fetus and newborn (anti-Rh antibodies)
Autoimmune hemolytic anemia
Graves' disease
Pemphigus vulgaris

Classification

Type II hypersensitivity is part of the Gell and Coombs classification of allergic reactions

Time Frame

Reaction development: immediate to hours after exposure

Complement Pathway

Classical pathway is activated in complement-dependent Type II hypersensitivity

Antibody Target

Antibodies are directed against antigens on cell surfaces or in extracellular matrix

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Description

Test your knowledge on Type II Hypersensitivity, an antibody-mediated process in which IgG and IgM antibodies attack antigens on cells or extracellular material leading to tissue damage or loss of function. Explore the mechanisms and consequences of this allergic reaction in this quiz.