12 Questions
Which type of antibodies are involved in Type II hypersensitivity?
IgM and IgG
What is the mechanism of tissue damage in Type II hypersensitivity?
Activation of complement system
What is an example of complement dependent Type II hypersensitivity?
Acute hemolytic transfusion reaction
What is Type II hypersensitivity in the Gell and Coombs classification of allergic reactions?
An antibody mediated process
What are the mechanisms involved in Type II hypersensitivity?
Complement activation, antibody-dependent cellular cytotoxicity, anti-receptor activity
What is an example of Type II hypersensitivity?
Acute hemolytic transfusion reaction
What is the mechanism of Type II hypersensitivity?
Antibody mediated process
What is the time frame for the development of reactions in Type II hypersensitivity?
2-24 hours
What is an example of antibody-dependent cellular cytotoxicity in Type II hypersensitivity?
Anti-receptor activity
Which complement pathway is activated in complement dependent Type II hypersensitivity?
Classical complement pathway
Which antibodies are directed against antigens in Type II hypersensitivity?
IgG and IgM
What is the time frame for the development of reactions in Type II hypersensitivity?
Hours to days
Study Notes
Type II Hypersensitivity
- Involves IgG and IgM antibodies
- Mechanism of tissue damage: antibodies bind to antigens on cell surfaces, leading to activation of complement system and destruction of cells
Mechanisms
- Antibody-dependent cellular cytotoxicity (ADCC)
- Complement-dependent cytotoxicity
- Phagocytosis
Examples
- Hemolytic disease of the fetus and newborn (anti-Rh antibodies)
- Autoimmune hemolytic anemia
- Graves' disease
- Pemphigus vulgaris
Classification
- Type II hypersensitivity is part of the Gell and Coombs classification of allergic reactions
Time Frame
- Reaction development: immediate to hours after exposure
Complement Pathway
- Classical pathway is activated in complement-dependent Type II hypersensitivity
Antibody Target
- Antibodies are directed against antigens on cell surfaces or in extracellular matrix
Test your knowledge on Type II Hypersensitivity, an antibody-mediated process in which IgG and IgM antibodies attack antigens on cells or extracellular material leading to tissue damage or loss of function. Explore the mechanisms and consequences of this allergic reaction in this quiz.
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