Anemia of Maturation Disorders and Megaloblastic Anemia Quiz
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Questions and Answers

Which laboratory test is used to confirm achlorhydria?

  • Holotranscobalamin assay
  • Serum gastrin levels (correct)
  • Antibody assays
  • Stool analysis for parasites

    • How are parietal cell antibodies commonly detected?

  • Stool analysis for parasites
  • Chemiluminescent immunometric assays
  • Holotranscobalamin assay
  • Indirect fluorescent antibody techniques (correct)

    • What is the metabolically active form of Vitamin B12?

  • Deoxyuridine suppression test
  • Holotranscobalamin (correct)
  • Antibody assays
  • Stool analysis for parasites

    • Which test is NOT supported as part of routine clinical testing for detecting Vitamin B12 deficiency?

    <p>Holotranscobalamin assay</p> Signup and view all the answers

    What does the Deoxyuridine suppression test determine lower levels of?

    <p>Vitamin B12 or Folate deficiency</p> Signup and view all the answers

    In pernicious anemia, what test is highly specific and confirmatory?

    <p>&quot;Indirect fluorescent antibody techniques&quot;</p> Signup and view all the answers

    Which of the following is NOT a characteristic of non-megaloblastic anemia with MCV > 100 fL?

    <p>Decreased reticulocyte count</p> Signup and view all the answers

    What is the primary cause of pernicious anemia, a type of megaloblastic anemia?

    <p>Anti-intrinsic factor antibodies</p> Signup and view all the answers

    What is the recommended dose for folic acid supplementation in the treatment of megaloblastic anemia caused by folate deficiency?

    <p>5 to 20 mg/day</p> Signup and view all the answers

    Which of the following is NOT a good dietary source of folate?

    <p>Enriched grains</p> Signup and view all the answers

    What is the recommended treatment for megaloblastic anemia caused by vitamin B12 deficiency?

    <p>Monthly injections of vitamin B12</p> Signup and view all the answers

    Which of the following conditions can cause non-megaloblastic anemia with MCV > 100 fL?

    <p>All of the above</p> Signup and view all the answers

    Which symptom is characteristic of congenital dyserythropoietic anemia?

    <p>Hepatosplenomegaly</p> Signup and view all the answers

    Which gene mutation is associated with Type 2 Congenital Dyserythropoietic Anemia?

    <p>SEC23B</p> Signup and view all the answers

    What is a common morphological feature of RBCs in Type 1 Congenital Dyserythropoietic Anemia?

    <p>Basophilic stippling</p> Signup and view all the answers

    In which type of anemia do you expect to see DNA synthesis unimpaired despite macrocytosis?

    <p>Nonmegaloblastic anemias</p> Signup and view all the answers

    What symptom is specifically associated with Type 3 Congenital Dyserythropoietic Anemia?

    <p>Dark stretches of thick membrane in RBCs</p> Signup and view all the answers

    Which type of anemia presents with a 'Swiss cheese erythroblast' morphology?

    <p>Congenital dyserythropoietic anemia</p> Signup and view all the answers

    What is the confirmatory test used to identify the megaloblastic appearance of developing red blood cells?

    <p>Deoxyuridine suppression test</p> Signup and view all the answers

    Which enzyme plays a role as a 'cofactor' in the conversion of methylmalonyl CoA to succinyl?

    <p>Methylmalonyl CoA mutase</p> Signup and view all the answers

    What is the result of deficiencies in either Folate or Vitamin B12 on homocysteine levels?

    <p>Elevated homocysteine levels</p> Signup and view all the answers

    What is an effect observed in bone marrow examination indicative of Vitamin B12 and Folate deficiency?

    <p>Diminished lobulation</p> Signup and view all the answers

    Which test for serum levels is preferred over RBC folate when diagnosing Folate deficiency?

    <p>Serum Folate assay</p> Signup and view all the answers

    What is a characteristic feature of the bone marrow during megaloblastic anemia observed through examination?

    <p>Presence of giant band WBCs</p> Signup and view all the answers

    What is the primary function of vitamin B12 in DNA synthesis?

    <p>It catalyzes the conversion of homocysteine to methionine, which is necessary for the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).</p> Signup and view all the answers

    Which of the following statements accurately describes the absorption of vitamin B12?

    <p>Vitamin B12 is initially bound to haptocorrin (R protein) in the stomach, and then to intrinsic factor secreted by the parietal cells in the small intestine for absorption.</p> Signup and view all the answers

    What is the primary cause of megaloblastic anemia in the context of vitamin B12 and folate deficiency?

    <p>Abnormal development of cellular nuclei resulting from impaired DNA synthesis.</p> Signup and view all the answers

    What is the primary role of folate in DNA synthesis?

    <p>It is involved in the transfer of methyl groups from donors to receptors, which is necessary for the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).</p> Signup and view all the answers

    Which of the following best describes the 'folate trap' mechanism in vitamin B12 deficiency?

    <p>Vitamin B12 deficiency leads to the accumulation of folate in its inactive form, 5-methyltetrahydrofolate (5-methyl THF), resulting in a functional folate deficiency.</p> Signup and view all the answers

    What is the primary cause of pernicious anemia?

    <p>Lack of intrinsic factor production by the parietal cells in the stomach, leading to impaired absorption of vitamin B12.</p> Signup and view all the answers

    Which of the following is a characteristic laboratory finding in megaloblastic anemia?

    <p>Presence of hypersegmented neutrophils in the peripheral blood smear.</p> Signup and view all the answers

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