Anemia of Maturation Disorders and Megaloblastic Anemia Quiz

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Which laboratory test is used to confirm achlorhydria?

Serum gastrin levels

How are parietal cell antibodies commonly detected?

Indirect fluorescent antibody techniques

What is the metabolically active form of Vitamin B12?

Holotranscobalamin

Which test is NOT supported as part of routine clinical testing for detecting Vitamin B12 deficiency?

Holotranscobalamin assay Signup and view all the answers

What does the Deoxyuridine suppression test determine lower levels of?

Vitamin B12 or Folate deficiency Signup and view all the answers

In pernicious anemia, what test is highly specific and confirmatory?

"Indirect fluorescent antibody techniques" Signup and view all the answers

Which of the following is NOT a characteristic of non-megaloblastic anemia with MCV > 100 fL?

Decreased reticulocyte count Signup and view all the answers

What is the primary cause of pernicious anemia, a type of megaloblastic anemia?

Anti-intrinsic factor antibodies Signup and view all the answers

What is the recommended dose for folic acid supplementation in the treatment of megaloblastic anemia caused by folate deficiency?

5 to 20 mg/day Signup and view all the answers

Which of the following is NOT a good dietary source of folate?

Enriched grains Signup and view all the answers

What is the recommended treatment for megaloblastic anemia caused by vitamin B12 deficiency?

Monthly injections of vitamin B12 Signup and view all the answers

Which of the following conditions can cause non-megaloblastic anemia with MCV > 100 fL?

All of the above Signup and view all the answers

Which symptom is characteristic of congenital dyserythropoietic anemia?

Hepatosplenomegaly Signup and view all the answers

Which gene mutation is associated with Type 2 Congenital Dyserythropoietic Anemia?

SEC23B Signup and view all the answers

What is a common morphological feature of RBCs in Type 1 Congenital Dyserythropoietic Anemia?

Basophilic stippling Signup and view all the answers

In which type of anemia do you expect to see DNA synthesis unimpaired despite macrocytosis?

Nonmegaloblastic anemias Signup and view all the answers

What symptom is specifically associated with Type 3 Congenital Dyserythropoietic Anemia?

Dark stretches of thick membrane in RBCs Signup and view all the answers

Which type of anemia presents with a 'Swiss cheese erythroblast' morphology?

Congenital dyserythropoietic anemia Signup and view all the answers

What is the confirmatory test used to identify the megaloblastic appearance of developing red blood cells?

Deoxyuridine suppression test Signup and view all the answers

Which enzyme plays a role as a 'cofactor' in the conversion of methylmalonyl CoA to succinyl?

Methylmalonyl CoA mutase Signup and view all the answers

What is the result of deficiencies in either Folate or Vitamin B12 on homocysteine levels?

Elevated homocysteine levels Signup and view all the answers

What is an effect observed in bone marrow examination indicative of Vitamin B12 and Folate deficiency?

Diminished lobulation Signup and view all the answers

Which test for serum levels is preferred over RBC folate when diagnosing Folate deficiency?

Serum Folate assay Signup and view all the answers

What is a characteristic feature of the bone marrow during megaloblastic anemia observed through examination?

Presence of giant band WBCs Signup and view all the answers

What is the primary function of vitamin B12 in DNA synthesis?

It catalyzes the conversion of homocysteine to methionine, which is necessary for the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Signup and view all the answers

Which of the following statements accurately describes the absorption of vitamin B12?

Vitamin B12 is initially bound to haptocorrin (R protein) in the stomach, and then to intrinsic factor secreted by the parietal cells in the small intestine for absorption. Signup and view all the answers

What is the primary cause of megaloblastic anemia in the context of vitamin B12 and folate deficiency?

Abnormal development of cellular nuclei resulting from impaired DNA synthesis. Signup and view all the answers

What is the primary role of folate in DNA synthesis?

It is involved in the transfer of methyl groups from donors to receptors, which is necessary for the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Signup and view all the answers

Which of the following best describes the 'folate trap' mechanism in vitamin B12 deficiency?

Vitamin B12 deficiency leads to the accumulation of folate in its inactive form, 5-methyltetrahydrofolate (5-methyl THF), resulting in a functional folate deficiency. Signup and view all the answers

What is the primary cause of pernicious anemia?

Lack of intrinsic factor production by the parietal cells in the stomach, leading to impaired absorption of vitamin B12. Signup and view all the answers

Which of the following is a characteristic laboratory finding in megaloblastic anemia?

Presence of hypersegmented neutrophils in the peripheral blood smear. Signup and view all the answers

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