Aldosterone Secretion and Hypertension

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What is the direct effect of aldosterone on the principal cells of the luminal membrane at the cortical collecting ducts of the kidneys?

Inhibition of Na+ channels

Decrease in Ca2+ reabsorption

Opening of Na+ channels (correct)

Increase in K+ secretion

What is the ultimate consequence of aldosterone's effect on the luminal membrane of the cortical collecting ducts?

Diuresis

Natriuresis

Hypertension (correct)

Hypotension

What would be the expected effect of a familial hyperaldosteronism on blood pressure?

Increased blood pressure (correct)

Decreased blood pressure

Fluctuating blood pressure

No change in blood pressure

Which of the following would NOT be a cause of excessive aldosterone production?

Aldosterone escape mechanism Signup and view all the answers

What is the mechanism by which the body regulates aldosterone production in response to high blood volume?

Aldosterone escape mechanism Signup and view all the answers

What is the primary response to which aldosterone secretion occurs in the renin-angiotensin-aldosterone system?

Detection of low blood pressure in the kidneys Signup and view all the answers

What is the effect of ACEI/ARB, diuretics, and CCB on renin activity?

Increase Signup and view all the answers

What is the term for the condition where aldosterone secretion is not regulated by the renin-angiotensin-aldosterone system?

Autonomous aldosterone secretion Signup and view all the answers

Which of the following is a condition characterized by the production of aldosterone from a non-adrenal source?

Ectopic aldosterone production Signup and view all the answers

What is the purpose of the sodium suppression test in diagnosing hyperaldosteronism?

To confirm failure to suppress aldosterone after sodium load Signup and view all the answers

Why is beta blocker avoided in patients with suspected hyperaldosteronism?

It increases the PAC/PRA ratio Signup and view all the answers

What is the term for the adaptation of the kidneys to excess aldosterone, leading to a decrease in sodium reabsorption and potassium secretion?

Aldosterone escape mechanism Signup and view all the answers

What is the significance of a positive oral salt load test in a patient with suspected hyperaldosteronism?

It suggests hyperaldosteronism if urinary aldosterone is >12 ug/d Signup and view all the answers

Which of the following is an inherited condition characterized by excessive aldosterone production and hypertension?

Familial hyperaldosteronism Signup and view all the answers

What is the limitation of CT/MRI imaging in diagnosing aldosterone-secreting tumors?

All of the above Signup and view all the answers

Aldosterone Secretion and Hypertension

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Questions and Answers

What is the direct effect of aldosterone on the principal cells of the luminal membrane at the cortical collecting ducts of the kidneys?

What is the ultimate consequence of aldosterone's effect on the luminal membrane of the cortical collecting ducts?

What would be the expected effect of a familial hyperaldosteronism on blood pressure?

Which of the following would NOT be a cause of excessive aldosterone production?

What is the mechanism by which the body regulates aldosterone production in response to high blood volume?

What is the primary response to which aldosterone secretion occurs in the renin-angiotensin-aldosterone system?

What is the effect of ACEI/ARB, diuretics, and CCB on renin activity?

What is the term for the condition where aldosterone secretion is not regulated by the renin-angiotensin-aldosterone system?

Which of the following is a condition characterized by the production of aldosterone from a non-adrenal source?

What is the purpose of the sodium suppression test in diagnosing hyperaldosteronism?

Why is beta blocker avoided in patients with suspected hyperaldosteronism?

What is the term for the adaptation of the kidneys to excess aldosterone, leading to a decrease in sodium reabsorption and potassium secretion?

What is the significance of a positive oral salt load test in a patient with suspected hyperaldosteronism?

Which of the following is an inherited condition characterized by excessive aldosterone production and hypertension?

What is the limitation of CT/MRI imaging in diagnosing aldosterone-secreting tumors?

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