Aldosterone Secretion and Hypertension
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Questions and Answers

What is the direct effect of aldosterone on the principal cells of the luminal membrane at the cortical collecting ducts of the kidneys?

  • Inhibition of Na+ channels
  • Decrease in Ca2+ reabsorption
  • Opening of Na+ channels (correct)
  • Increase in K+ secretion
  • What is the ultimate consequence of aldosterone's effect on the luminal membrane of the cortical collecting ducts?

  • Diuresis
  • Natriuresis
  • Hypertension (correct)
  • Hypotension
  • What would be the expected effect of a familial hyperaldosteronism on blood pressure?

  • Increased blood pressure (correct)
  • Decreased blood pressure
  • Fluctuating blood pressure
  • No change in blood pressure
  • Which of the following would NOT be a cause of excessive aldosterone production?

    <p>Aldosterone escape mechanism</p> Signup and view all the answers

    What is the mechanism by which the body regulates aldosterone production in response to high blood volume?

    <p>Aldosterone escape mechanism</p> Signup and view all the answers

    What is the primary response to which aldosterone secretion occurs in the renin-angiotensin-aldosterone system?

    <p>Detection of low blood pressure in the kidneys</p> Signup and view all the answers

    What is the effect of ACEI/ARB, diuretics, and CCB on renin activity?

    <p>Increase</p> Signup and view all the answers

    What is the term for the condition where aldosterone secretion is not regulated by the renin-angiotensin-aldosterone system?

    <p>Autonomous aldosterone secretion</p> Signup and view all the answers

    Which of the following is a condition characterized by the production of aldosterone from a non-adrenal source?

    <p>Ectopic aldosterone production</p> Signup and view all the answers

    What is the purpose of the sodium suppression test in diagnosing hyperaldosteronism?

    <p>To confirm failure to suppress aldosterone after sodium load</p> Signup and view all the answers

    Why is beta blocker avoided in patients with suspected hyperaldosteronism?

    <p>It increases the PAC/PRA ratio</p> Signup and view all the answers

    What is the term for the adaptation of the kidneys to excess aldosterone, leading to a decrease in sodium reabsorption and potassium secretion?

    <p>Aldosterone escape mechanism</p> Signup and view all the answers

    What is the significance of a positive oral salt load test in a patient with suspected hyperaldosteronism?

    <p>It suggests hyperaldosteronism if urinary aldosterone is &gt;12 ug/d</p> Signup and view all the answers

    Which of the following is an inherited condition characterized by excessive aldosterone production and hypertension?

    <p>Familial hyperaldosteronism</p> Signup and view all the answers

    What is the limitation of CT/MRI imaging in diagnosing aldosterone-secreting tumors?

    <p>All of the above</p> Signup and view all the answers

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