Adenovirus Infections in Humans: Pathogenesis
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Questions and Answers

What is the primary mode of transmission for adenoviruses in humans?

  • Through airborne transmission
  • By direct contact with infected individuals (correct)
  • Through contaminated food and water
  • By insect vectors

    • Which of the following is a characteristic of adenovirus infections in humans?

  • Adenoviruses typically spread beyond the regional lymph nodes
  • Adenoviruses are RNA viruses with a linear genome
  • Adenoviruses only cause overt symptoms in the gastrointestinal tract
  • Adenoviruses can persist as latent infections in adenoids and tonsils (correct)

    • What is the primary method used for laboratory diagnosis of adenovirus infections?

  • Serological tests to detect antibodies
  • Virus isolation through cell culture
  • Histopathological examination of tissue samples
  • Polymerase chain reaction (PCR) assays (correct)

    • Which of the following is a characteristic of the adenovirus genome?

    <p>It is a DNA virus with a linear genome</p> Signup and view all the answers

    What is the primary clinical manifestation of adenovirus infections in humans?

    <p>Asymptomatic or subclinical infections</p> Signup and view all the answers

    What is the recommended approach for collecting samples for adenovirus diagnosis?

    <p>Collect samples from multiple sites, including the affected areas, early in the illness</p> Signup and view all the answers

    Which of the following best describes the pathogenesis of adenovirus infections?

    <p>Adenoviruses infect and replicate primarily in epithelial cells of various body sites.</p> Signup and view all the answers

    Which of the following statements about adenovirus persistence is correct?

    <p>Group C adenoviruses persist as latent infections in adenoids and tonsils for years.</p> Signup and view all the answers

    What is the significance of the name 'adenovirus'?

    <p>It reflects the recovery of the initial isolate from explants of human adenoids.</p> Signup and view all the answers

    Which of the following statements about adenovirus infections in the gastrointestinal tract is correct?

    <p>Most human adenoviruses replicate in intestinal epithelium after ingestion but usually produce subclinical infections.</p> Signup and view all the answers

    Which of the following sample types should be collected early in the course of an adenovirus infection for optimal virus isolation?

    <p>Stool, urine, or swabs from affected sites</p> Signup and view all the answers

    What is the primary method used for laboratory diagnosis of adenovirus infections?

    <p>Polymerase chain reaction (PCR) assays</p> Signup and view all the answers

    Adenoviruses can spread beyond the regional lymph nodes.

    <p>False</p> Signup and view all the answers

    Group C adenoviruses remain as active infections for years in adenoids and tonsils.

    <p>False</p> Signup and view all the answers

    Most human adenoviruses cause clinically observable symptoms upon intestinal epithelium replication.

    <p>False</p> Signup and view all the answers

    Polymerase chain reaction (PCR) assays are not commonly used for the diagnosis of adenovirus infections.

    <p>False</p> Signup and view all the answers

    Infection with any adenovirus type does not lead to the production of complement-fixing antibodies.

    <p>False</p> Signup and view all the answers

    There is a specific treatment available for adenovirus infections in humans.

    <p>False</p> Signup and view all the answers

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