Viral Infections and Common Cold
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Questions and Answers

What is the most common cause of the common cold?

  • Coronaviruses
  • Rhinoviruses (correct)
  • Adenoviruses
  • Parainfluenza
  • Which symptom is NOT typically associated with a rhinovirus infection causing a common cold?

  • Cough
  • Nasal discharge
  • Chest pain (correct)
  • Sore throat
  • Which viral infection is most commonly associated with hoarseness?

  • Bronchiolitis
  • Pneumonia
  • Common cold
  • Laryngotracheitis (correct)
  • What is the primary method of viral replication for rhinoviruses?

    <p>In the cytoplasm of the nasal mucosal surface epithelium (B)</p> Signup and view all the answers

    Which of the following is a common viral cause of pneumonia in adults?

    <p>Influenza (D)</p> Signup and view all the answers

    During the pathogenesis of a rhinovirus infection, what role do mediators such as bradykinin and histamine play?

    <p>They contribute to inflammatory responses. (D)</p> Signup and view all the answers

    What percentage of common cold cases are caused by rhinoviruses?

    <p>More than 50% (A)</p> Signup and view all the answers

    What is the incubation period for rhinovirus infections?

    <p>2-4 days (D)</p> Signup and view all the answers

    What structure do enveloped positive-sense RNA viruses possess?

    <p>Helical capsid (A)</p> Signup and view all the answers

    What role do glycoproteins S and HE play in the infection process of enveloped RNA viruses?

    <p>They facilitate adherence to respiratory mucosa. (A)</p> Signup and view all the answers

    Where does the replication of adenoviruses occur?

    <p>Nucleus (C)</p> Signup and view all the answers

    Which method is not typically used for diagnosing adenovirus infections?

    <p>Direct visualization via electron microscopy (B)</p> Signup and view all the answers

    What phenomenon may occur through immunopathogenesis in viral infections?

    <p>Destruction of infected cells (D)</p> Signup and view all the answers

    What is a defining characteristic of adenoviruses compared to enveloped RNA viruses?

    <p>Non-enveloped structure (C)</p> Signup and view all the answers

    Which of the following viruses is NOT listed as causing upper and lower respiratory tract infections?

    <p>Rotavirus (D)</p> Signup and view all the answers

    What is the primary method of virus release for enveloped positive-sense RNA viruses?

    <p>Fusion with the plasma membrane (C)</p> Signup and view all the answers

    Which viral infection is primarily characterized by cough and dyspnea in infants?

    <p>Bronchiolitis (A)</p> Signup and view all the answers

    What is a common symptom associated with the common cold?

    <p>Sore throat (B)</p> Signup and view all the answers

    Which of the following viruses is recognized as a major cause of pneumonia in adults?

    <p>Parainfluenza virus (D)</p> Signup and view all the answers

    What characteristic is unique to rhinoviruses compared to other respiratory viruses?

    <p>More than 100 serotypes (C)</p> Signup and view all the answers

    Which symptom is commonly associated with the infection caused by parainfluenza viruses?

    <p>Cough (D)</p> Signup and view all the answers

    During the pathogenesis of rhinovirus infection, which receptor is primarily utilized for viral adhesion?

    <p>ICAM 1 (A)</p> Signup and view all the answers

    What laboratory method is commonly used for the diagnosis of rhinovirus infections?

    <p>PCR (B)</p> Signup and view all the answers

    What is the typical incubation period for infections caused by rhinoviruses?

    <p>2-4 days (D)</p> Signup and view all the answers

    What component of the enveloped positive-sense RNA viruses is responsible for hemagglutination?

    <p>HE spikes (C)</p> Signup and view all the answers

    Where does the replication of the positive-sense RNA viruses primarily occur?

    <p>Cytoplasm of infected cells (C)</p> Signup and view all the answers

    Which diagnostic method is commonly used for detecting adenovirus infections?

    <p>PCR (C)</p> Signup and view all the answers

    What is a common characteristic of the adenovirus structure?

    <p>Non-enveloped icosahedral configuration (B)</p> Signup and view all the answers

    During the pathogenesis of adenovirus infections, where do the early viral mRNA and proteins get synthesized?

    <p>Nucleus (B)</p> Signup and view all the answers

    What role does the fiber protein have in adenoviruses?

    <p>Viral entry (B)</p> Signup and view all the answers

    How are newly formed virions from enveloped positive-sense RNA viruses released from the cell?

    <p>Fusion with plasma membrane (C)</p> Signup and view all the answers

    What is a key feature that distinguishes adenovirus infections from other viral infections in the upper respiratory tract?

    <p>Presence of fiber proteins (B)</p> Signup and view all the answers

    What is the primary site of replication for positive-sense enveloped RNA viruses?

    <p>Cytoplasm (C)</p> Signup and view all the answers

    How do adenoviruses typically attach to host cells?

    <p>Through fiber proteins (C)</p> Signup and view all the answers

    Which method is NOT commonly used to isolate adenoviruses?

    <p>Animal model studies (B)</p> Signup and view all the answers

    What role do S glycoprotein and HE spikes play in the infection cycle of enveloped positive-sense RNA viruses?

    <p>They help in viral attachment to host cell receptors. (A)</p> Signup and view all the answers

    What characterizes the method of release for newly formed virions of enveloped positive-sense RNA viruses?

    <p>Vesicle fusion with the plasma membrane (C)</p> Signup and view all the answers

    Which of the following serotypes of adenoviruses is associated with upper respiratory tract infections?

    <p>Serotype 7 (A)</p> Signup and view all the answers

    In which part of the cell does adenovirus replication occur?

    <p>Nucleus (D)</p> Signup and view all the answers

    What is a common diagnostic method for detecting viral infections caused by adenoviruses?

    <p>Detection of increased specific antibody titer (A)</p> Signup and view all the answers

    Which of the following viruses is the most common cause of the common cold in adults?

    <p>Rhinoviruses (A)</p> Signup and view all the answers

    Which symptom is typically associated with both pharyngitis and pneumonia caused by adenoviruses?

    <p>Cough (D)</p> Signup and view all the answers

    What is the primary method of viral adhesion used by rhinoviruses?

    <p>Attachment to ICAM 1 receptors (C)</p> Signup and view all the answers

    Which of the following statements about the replication of rhinoviruses is accurate?

    <p>Viral RNA serves as mRNA for protein synthesis (D)</p> Signup and view all the answers

    In infants, which of the following viruses is primarily responsible for causing bronchiolitis?

    <p>Respiratory Syncytial Virus (RSV) (D)</p> Signup and view all the answers

    Which inflammatory mediators are linked to the symptoms of a rhinovirus-induced cold?

    <p>Bradykinin, histamine, and prostaglandins (A)</p> Signup and view all the answers

    Which of the following viruses is often implicated in causing laryngotracheitis?

    <p>Parainfluenza virus (A)</p> Signup and view all the answers

    Which of the following conditions is noted as a potential complication of a rhinovirus infection?

    <p>Acute otitis media (A)</p> Signup and view all the answers

    Flashcards

    Rhinoviruses

    The most common cause of the common cold, rhinoviruses are small, non-enveloped viruses with a positive-sense, single-stranded RNA genome.

    Rhinovirus Replication

    Rhinoviruses infect the nasal mucosa, attaching to specific receptors like ICAM-1. They replicate in the cytoplasm of epithelial cells, producing new viral RNA and proteins.

    Rhinovirus Symptoms

    Rhinoviruses cause a range of symptoms, from sneezing and nasal congestion to sore throat, and can sometimes lead to secondary bacterial infections such as sinusitis or pneumonia.

    Coronaviruses

    Coronaviruses are another common cause of the common cold, known for their distinctive crown-like appearance under a microscope.

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    Common Cold Transmission

    Common cold viruses like rhinoviruses spread through the air by droplets produced when an infected person coughs or sneezes.

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    Coronavirus Replication

    Similar to rhinoviruses, Coronaviruses also attach to host cells and replicate within them, causing symptoms like congestion, sneezing, and runny nose.

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    Parainfluenza Viruses

    Parainfluenza viruses, like influenza, are responsible for Laryngotracheitis, also known as croup, characterized by a harsh cough that resembles a bark.

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    Parainfluenza Replication

    Parainfluenza viruses replicate in the upper respiratory tract, mainly affecting the larynx and trachea, leading to inflammation and characteristic symptoms like stridor (noisy breathing) and a hoarse cough.

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    What are +ve sense RNA enveloped viruses?

    A type of virus with a single-stranded RNA genome that is enclosed in a lipid bilayer envelope. They are known for causing a range of respiratory illnesses, including the common cold.

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    What is the capsid structure of +ve sense RNA enveloped viruses?

    These viruses have a helical capsid structure, which means they are shaped like a spiral. This structure gives them a distinct appearance under a microscope.

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    What are the spikes on +ve sense RNA enveloped viruses?

    They contain spikes on their surface, which are glycoproteins that allow them to attach to host cells. These spikes are important for the virus to enter the host cell and cause infection.

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    Where do +ve sense RNA enveloped viruses replicate?

    Replication of these viruses occurs in the cytoplasm of infected cells.

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    Describe the structure of Adenoviruses.

    These viruses are non-enveloped, meaning they lack a lipid bilayer surrounding their capsid. They have a unique structure with fiber proteins that extend from their surface.

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    How do Adenoviruses replicate?

    This virus is a double-stranded DNA virus that replicates in the nucleus of infected cells. It uses the host cell's DNA polymerase to create viral proteins.

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    Where can Adenoviruses remain latent?

    Adenoviruses can remain dormant in the adenoid or tonsillar tissues of the throat, potentially leading to future infections.

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    What are some respiratory illnesses caused by Adenoviruses?

    These are common causes of respiratory illnesses, including colds, pharyngitis, and pneumonia. Each serotype has a specific set of fiber proteins, determining its ability to cause different infections.

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    What is the structure of Adenoviruses?

    These are non-enveloped viruses with a double-stranded linear DNA genome and an icosahedral capsid. They are unique because they have fiber proteins projecting from the capsid.

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    How do +ve sense RNA enveloped viruses enter the respiratory tract?

    These viruses infect the respiratory mucosa via the S or HE glycoproteins, attaching to aminopeptidase N receptors.

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    What are rhinoviruses?

    Rhinoviruses are the most common cause of the common cold. They are small, non-enveloped viruses with a positive-sense, single-stranded RNA genome.

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    How do rhinoviruses replicate?

    Rhinoviruses infect the nasal mucosa, attaching to specific receptors like ICAM-1. They replicate in the cytoplasm of epithelial cells, producing new viral RNA and proteins.

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    What are the symptoms of a rhinovirus infection?

    Rhinoviruses cause a range of symptoms, from sneezing and nasal congestion to sore throat, and can sometimes lead to secondary bacterial infections such as sinusitis or pneumonia.

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    What are coronaviruses?

    Coronaviruses are another common cause of the common cold. They are characterized by a distinctive crown-like appearance under a microscope.

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    How are coronaviruses transmitted?

    Coronaviruses spread through the air by droplets produced when an infected person coughs or sneezes.

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    What are Parainfluenza viruses and what do they cause?

    Parainfluenza viruses are a common cause of Laryngotracheitis, also known as Croup. These viruses replicate in the upper respiratory tract, mainly affecting the larynx and trachea, leading to inflammation and characteristic symptoms like stridor (noisy breathing) and a hoarse cough.

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    What are Adenoviruses?

    Adenoviruses are a major cause of upper respiratory tract infections. They have a unique structure with fiber proteins that extend from their surface. They are non-enveloped viruses, meaning they lack a lipid bilayer surrounding their capsid.

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    What infections are caused by adenoviruses?

    Adenoviruses are a major cause of upper respiratory tract infections. They are known to cause colds, pharyngitis, and pneumonia.

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    What is the significance of coronaviruses?

    These viruses are the second most common cause of the common cold.

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    What is the structure of positive sense RNA enveloped viruses?

    These viruses have a helical capsid, meaning their shape is like a spiral. They're also enveloped, meaning they have a lipid bilayer membrane surrounding them. The spikes on their surface are glycoproteins like S and HE, which help them attach to host cells.

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    How do positive sense RNA enveloped viruses enter the respiratory system?

    They enter the respiratory tract by attaching to aminopeptidase N receptors using either their S or HE glycoprotein spikes.

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    Where do positive sense RNA enveloped viruses replicate?

    They replicate in the cytoplasm of infected cells. This means all the machinery they need to make copies of themselves is found within the cell's main fluid-filled area.

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    What are the key features of adenoviruses?

    They are non-enveloped, meaning they lack a lipid bilayer membrane surrounding their capsid. They have a unique structure with fiber proteins extending from their surface.

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    What illnesses can adenoviruses cause?

    They cause respiratory illnesses, including colds, pharyngitis and pneumonia. Each serotype has a specific set of fiber proteins, determining its ability to cause different infections.

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