Actinic Keratosis and Nonmelanocytic Malignant Skin Tumors
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Questions and Answers

What microscopic features are commonly seen in the stratum corneum of actinic keratosis?

  • Acantholysis and spongiosis
  • Hyperkeratosis and parakeratosis (correct)
  • Dermal elastosis and acanthosis
  • Acanthosis and psoriasiform hyperplasia
  • Which type of UV radiation reaches the dermis and indirectly causes DNA damage?

  • UV-C (100 nm)
  • UV-B and UV-C combined
  • UV-A (400nm) (correct)
  • UV-B (320nm)
  • What protein is primarily involved in the pathogenesis of Basal Cell Carcinoma (BCC)?

  • Hedgehog proteins
  • Merkel cell polyomavirus
  • p53 gene
  • PTCH gene- protein patched homolog 1 (correct)
  • What is a common risk factor for developing Basal Cell Carcinoma?

    <p>UV exposure</p> Signup and view all the answers

    What type of therapy involves the use of Hedgehog pathway inhibitors for treating Basal Cell Carcinoma?

    <p>Pharmacologic therapy</p> Signup and view all the answers

    Which type of Hedgehog protein is considered the most potent and most often expressed?

    <p>Sonic Hedgehog (SHH)</p> Signup and view all the answers

    What is the main function of Hedgehog proteins in cellular processes?

    <p>Cell specification, proliferation, and differentiation</p> Signup and view all the answers

    Which type of skin tumor presents as small rough spots and may have cutaneous horns?

    <p><strong>Actinic Keratosis</strong></p> Signup and view all the answers

    Which of the following is NOT a risk factor for Squamous Cell Carcinoma?

    <p>Genetic mutations in signaling pathways</p> Signup and view all the answers

    What is the typical presentation of Merkel Cell Carcinoma?

    <p>Painless nodules that grow slowly</p> Signup and view all the answers

    Which histological pattern is NOT associated with Squamous Cell Carcinoma?

    <p>Adenomatous</p> Signup and view all the answers

    Which type of cancer is derived from keratinocytes in the epidermal layer?

    <p>Squamous cell carcinoma</p> Signup and view all the answers

    What microscopic feature is characteristic of Acantholytic Squamous Cell Carcinoma?

    <p>Loss of intercellular connection (Acantholysis)</p> Signup and view all the answers

    Which neuroendocrine markers are expressed in Merkel Cell Carcinoma?

    <p>CD56 and Chromogranin</p> Signup and view all the answers

    Which cancers are associated with nevoid basal cell carcinoma syndrome?

    <p>(BCC) in skin and Medulloblastomas in brain</p> Signup and view all the answers

    What is the most common type of cutaneous T cell lymphoma?

    <p>Mycosis Fungoides</p> Signup and view all the answers

    Which of the following is a microscopic feature of the 'Patch' stage of Mycosis Fungoides?

    <p>Clustered in epidermis</p> Signup and view all the answers

    Which condition is characterized by large irregular lumps developing from plaques and has dense dermal infiltrates with cerebriform nuclei as a microscopic feature?

    <p>Plaque stage of Mycosis Fungoides</p> Signup and view all the answers

    What are the neoplastic T cells with cerebriform nuclei found in?

    <p>Sézary syndrome</p> Signup and view all the answers

    Which condition is indicated by the presence of neoplastic T cells that are positive for CD4 and negative for CD8?

    <p>Mycosis Fungoides</p> Signup and view all the answers

    Which condition is characterized by monotonous round tumor cells?

    <p>Mycosis Fungoides</p> Signup and view all the answers

    What is the common feature of the microscopic appearance in Sézary syndrome?

    <p>Tumor cells found in peripheral blood</p> Signup and view all the answers

    Which condition presents with erythroderma, lymphadenopathy, and neoplastic T cells with cerebriform nuclei?

    <p>'Plaque' stage of Mycosis Fungoides</p> Signup and view all the answers

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