Actinic Keratosis and Nonmelanocytic Malignant Skin Tumors

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What microscopic features are commonly seen in the stratum corneum of actinic keratosis?

Acantholysis and spongiosis

Hyperkeratosis and parakeratosis (correct)

Dermal elastosis and acanthosis

Acanthosis and psoriasiform hyperplasia

Which type of UV radiation reaches the dermis and indirectly causes DNA damage?

UV-C (100 nm)

UV-B and UV-C combined

UV-A (400nm) (correct)

UV-B (320nm)

What protein is primarily involved in the pathogenesis of Basal Cell Carcinoma (BCC)?

Hedgehog proteins

Merkel cell polyomavirus

p53 gene

PTCH gene- protein patched homolog 1 (correct)

What is a common risk factor for developing Basal Cell Carcinoma?

UV exposure Signup and view all the answers

What type of therapy involves the use of Hedgehog pathway inhibitors for treating Basal Cell Carcinoma?

Pharmacologic therapy Signup and view all the answers

Which type of Hedgehog protein is considered the most potent and most often expressed?

Sonic Hedgehog (SHH) Signup and view all the answers

What is the main function of Hedgehog proteins in cellular processes?

Cell specification, proliferation, and differentiation Signup and view all the answers

Which type of skin tumor presents as small rough spots and may have cutaneous horns?

Actinic Keratosis Signup and view all the answers

Which of the following is NOT a risk factor for Squamous Cell Carcinoma?

Genetic mutations in signaling pathways Signup and view all the answers

What is the typical presentation of Merkel Cell Carcinoma?

Painless nodules that grow slowly Signup and view all the answers

Which histological pattern is NOT associated with Squamous Cell Carcinoma?

Adenomatous Signup and view all the answers

Which type of cancer is derived from keratinocytes in the epidermal layer?

Squamous cell carcinoma Signup and view all the answers

What microscopic feature is characteristic of Acantholytic Squamous Cell Carcinoma?

Loss of intercellular connection (Acantholysis) Signup and view all the answers

Which neuroendocrine markers are expressed in Merkel Cell Carcinoma?

CD56 and Chromogranin Signup and view all the answers

Which cancers are associated with nevoid basal cell carcinoma syndrome?

(BCC) in skin and Medulloblastomas in brain Signup and view all the answers

What is the most common type of cutaneous T cell lymphoma?

Mycosis Fungoides Signup and view all the answers

Which of the following is a microscopic feature of the 'Patch' stage of Mycosis Fungoides?

Clustered in epidermis Signup and view all the answers

Which condition is characterized by large irregular lumps developing from plaques and has dense dermal infiltrates with cerebriform nuclei as a microscopic feature?

Plaque stage of Mycosis Fungoides Signup and view all the answers

What are the neoplastic T cells with cerebriform nuclei found in?

Sézary syndrome Signup and view all the answers

Which condition is indicated by the presence of neoplastic T cells that are positive for CD4 and negative for CD8?

Mycosis Fungoides Signup and view all the answers

Which condition is characterized by monotonous round tumor cells?

Mycosis Fungoides Signup and view all the answers

What is the common feature of the microscopic appearance in Sézary syndrome?

Tumor cells found in peripheral blood Signup and view all the answers

Which condition presents with erythroderma, lymphadenopathy, and neoplastic T cells with cerebriform nuclei?

'Plaque' stage of Mycosis Fungoides Signup and view all the answers

Actinic Keratosis and Nonmelanocytic Malignant Skin Tumors

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Questions and Answers

What microscopic features are commonly seen in the stratum corneum of actinic keratosis?

Which type of UV radiation reaches the dermis and indirectly causes DNA damage?

What protein is primarily involved in the pathogenesis of Basal Cell Carcinoma (BCC)?

What is a common risk factor for developing Basal Cell Carcinoma?

What type of therapy involves the use of Hedgehog pathway inhibitors for treating Basal Cell Carcinoma?

Which type of Hedgehog protein is considered the most potent and most often expressed?

What is the main function of Hedgehog proteins in cellular processes?

Which type of skin tumor presents as small rough spots and may have cutaneous horns?

Which of the following is NOT a risk factor for Squamous Cell Carcinoma?

What is the typical presentation of Merkel Cell Carcinoma?

Which histological pattern is NOT associated with Squamous Cell Carcinoma?

Which type of cancer is derived from keratinocytes in the epidermal layer?

What microscopic feature is characteristic of Acantholytic Squamous Cell Carcinoma?

Which neuroendocrine markers are expressed in Merkel Cell Carcinoma?

Which cancers are associated with nevoid basal cell carcinoma syndrome?

What is the most common type of cutaneous T cell lymphoma?

Which of the following is a microscopic feature of the 'Patch' stage of Mycosis Fungoides?

Which condition is characterized by large irregular lumps developing from plaques and has dense dermal infiltrates with cerebriform nuclei as a microscopic feature?

What are the neoplastic T cells with cerebriform nuclei found in?

Which condition is indicated by the presence of neoplastic T cells that are positive for CD4 and negative for CD8?

Which condition is characterized by monotonous round tumor cells?

What is the common feature of the microscopic appearance in Sézary syndrome?

Which condition presents with erythroderma, lymphadenopathy, and neoplastic T cells with cerebriform nuclei?

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