AAV Immune Response and Possible Therapies for Various Diseases
12 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which characteristic of the Vaccinia virus genome is mentioned in the text?

  • Circular, single-stranded DNA
  • Linear, single-stranded RNA
  • Linear, double-stranded DNA (correct)
  • Circular, double-stranded RNA

    • What is the primary location for replication of the Vaccinia virus within the host cell?

  • Cytoplasm (correct)
  • Nucleus
  • Endoplasmic reticulum
  • Mitochondria

    • Which of the following diseases is caused by the Variola virus?

  • Rubella
  • Chickenpox
  • Measles
  • Smallpox (correct)

    • What is the primary characteristic that differentiates Poxviridae from other viruses?

    <p>Having a brick-shaped appearance</p> Signup and view all the answers

    In AAV vectors, what is the significance of Inverted Terminal Repeats (ITRs)?

    <p>They serve as a site for integration into the host chromosome</p> Signup and view all the answers

    What is the primary humoral immune response responsible for regarding AAV vectors?

    <p>Neutralization of AAV vectors</p> Signup and view all the answers

    Which chromosome does the adeno-associated virus (AAV) genome integrate into during site-specific integration?

    <p>Chromosome 19q13.4</p> Signup and view all the answers

    What are the sequences at the ends of the AAV genome called, and what is their function?

    <p>Inverted terminal repeats (ITRs), required for efficient multiplication and integration of the AAV genome</p> Signup and view all the answers

    What are the two open reading frames (ORFs) present in the AAV genome, and what are their functions?

    <p>Rep gene (regulates AAV gene expression) and Cap gene (encodes viral capsid proteins)</p> Signup and view all the answers

    What is the primary difference between recombinant AAV (rAAV) vectors and self-complementary (scAAV) recombinant vectors?

    <p>rAAV vectors require second-strand synthesis before gene expression, while scAAV vectors have a shorter lag time</p> Signup and view all the answers

    What is the primary function of the Rep gene in the AAV genome?

    <p>Regulates AAV gene expression and DNA replication</p> Signup and view all the answers

    How are the positive (+) and negative (-) strands of the AAV genome packaged into the viral capsid?

    <p>Both strands are packaged with equal frequency</p> Signup and view all the answers

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser