Hemostasis Part 1
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Questions and Answers

Composed of rhomboid cells

  • Anticoagulant (correct)
  • Procoagulant
  • C
  • D

Prostacyclin, TFPI, Protein C, Thrombomodulin(activates C and TAFI), tPA

  • Anticoagulant (correct)
  • Procoagulant
  • C
  • D

Nitric oxide, Heparan sulfate

  • Anticoagulant (correct)
  • Procoagulant
  • C
  • D

VWF or Fibrinogen GPIb/IX/V

<p>VWF</p> Signup and view all the answers

VWF/Fibrinogen. GPIIb/IIIa

<p>Fibrinogen</p> Signup and view all the answers

Gp_. Collagen. V or VI or VII

<p>VI</p> Signup and view all the answers

Reversible

<p>Adhesion (A)</p> Signup and view all the answers

These are zymogens that are converted to serine proteases. The last one is not converted to a serine protease, but a transglutaminase.

<p>279101112pk13</p> Signup and view all the answers

Cofactors

<p>358hmwk</p> Signup and view all the answers

Intrinsic pathway

<p>891112</p> Signup and view all the answers

Extrinsic pathway

<p>37</p> Signup and view all the answers

Common pathway

<p>12510</p> Signup and view all the answers

Fibrinogen group

<p>135813</p> Signup and view all the answers

Fibrinogen group is

<p>Vitk independent, Ca dependent (B)</p> Signup and view all the answers

Prothrombin group is

<p>Vitk and Ca dep (A)</p> Signup and view all the answers

Contact group is vitk and ca independent

<p>True (A)</p> Signup and view all the answers

Prothrombin group is

<p>27910</p> Signup and view all the answers

Contact group involves 10 12 pk and hmwk, t or f

<p>F</p> Signup and view all the answers

Gwapong pangalan, sino sila. 4 letter.

<p>Hmwk</p> Signup and view all the answers

Extrinsic or intrinsic, tenase that has 7, TF(3) phospholipid and ca. Activates 9 and 10.

<p>Extrinsic</p> Signup and view all the answers

Extrinsic or intrinsic. Tenase that has IXa, VIIIa, phospholipid and Ca. Activates 10.

<p>Intrinsic</p> Signup and view all the answers

Prothrombinase complex involves 5a 10a phospholipid and Ca. Activates prothrombin. T or f

<p>T</p> Signup and view all the answers

Has a mean plasma concentration of 200-400 mgdL

<p>Fibrinogen (A)</p> Signup and view all the answers

Fibrinogen is the ultimate substrate of the coagation pathway

<p>True (A)</p> Signup and view all the answers

Flashcards

Anticoagulants

Substances that prevent blood clot formation.

Major Anticoagulants

Anticoagulant molecules including prostacyclin, TFPI, Protein C, Thrombomodulin, and tPA.

Other Anticoagulants

Anticoagulant molecules including Nitric oxide and Heparan sulfate.

VWF Function

Binds to GPIb/IX/V; facilitates platelet adhesion to damaged vessel walls.

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Fibrinogen Function

Binds to GPIIb/IIIa on activated platelets, linking them together to form a platelet plug.

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GpVI

Collagen receptor on platelets; initiates adhesion to exposed collagen.

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Platelet Adhesion

The initial, often weak, attachment of platelets to the injured vessel wall.

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Coagulation Factors (Zymogens)

Factors II, VII, IX, X, XI, XII, Prekallikrein (PK), High Molecular Weight Kininogen (HMWK) are zymogens converted to serine proteases except for factor XIII which is a transglutaminase.

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Coagulation Factors (Cofactors)

Factors III, V, VIII, HMWK.

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Intrinsic Pathway

The coagulation pathway involving factors VIII, IX, XI, and XII.

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Extrinsic Pathway

The coagulation pathway initiated by Tissue Factor (Factor III) and Factor VII.

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Common Pathway

The convergence of the intrinsic and extrinsic pathways, involving factors I, II, V, and X.

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Fibrinogen Group

Fibrinogen, Factors I, III, V, VIII, XIII.

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Fibrinogen Group Characteristics

Factors I, III, V, VIII, XIII are vitamin K independent and calcium dependent.

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Prothrombin Group

Factors II, VII, IX, and X are vitamin K and calcium dependent.

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Prothrombin Group Factors

Factors II, VII, IX, and X.

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HMWK

High Molecular Weight Kininogen (HMWK).

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Extrinsic Tenase Complex

Tissue Factor (VII), phospholipid, and calcium activate Factor X. It activates the extrinsic pathway activating 9 and 10.

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Intrinsic Tenase Complex

Factors IXa, VIIIa, phospholipid, and calcium activate Factor 10.

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Prothrombinase Complex

Factors Va, Xa, phospholipid, and calcium activate prothrombin.

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Tenase Complex Action

The tenase complex activates Factor X to Xa.

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Contact group characteristics

Contact group. XII, Prekallekrein (PK), High Molecular Weight Kininogen (HMWK).

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