Y1S1_MHSBLAB_1_CELL ORIENTATION.docx.pdf

(MICRO LAB) – (MICROSCOPIC HUMAN STRUCTURAL BIOLOGY 1A) (CELL ORIENTATION & Dr. Grace M. Bardelosa) (Y1S1_Week 1_August/2024) DIMAYACYAC - SALAMANCA - SALAS - SAMSON - SANCHEZ - SANTIAGO - SAROCA - SICAT - TABBILO...

(MICRO LAB) – (MICROSCOPIC HUMAN STRUCTURAL BIOLOGY 1A) (CELL ORIENTATION & Dr. Grace M. Bardelosa) (Y1S1_Week 1_August/2024) DIMAYACYAC - SALAMANCA - SALAS - SAMSON - SANCHEZ - SANTIAGO - SAROCA - SICAT - TABBILOS - TALOSIG - TAWASIL - TEOPENGCO - ULANG - UMALI - VENDIVIL OUTLINE The hepatocytes are arranged in cords, rows, columns, or Cellular Structures chains, they are polygonal in shape with a mono or ○ Liver binucleated nucleus which is centrally located ○ Skeletal Muscle The spaces between the liver cells containing mixed blood ○ Spinal Cord ○ Compact Bone are called hepatic sinusoids ○ Skin Epidermis REFERENCES Laboratory Orientation in Cellular Structures PPT LIVER PARENCHYMA Hepatocytes or liver cell CELLULAR STRUCTURES SHAPE Polygonal/ polyhedral LIVER ARRANGEMENT Rows/cords/ chains NUMBER OF NUCLEUS Mono or binucleated (nucleation) LOCATION OF NUCLEUS Central SKELETAL MUSCLE Divided into lobules Central vein is at the center of each lobule Hepatocytes or Liver cells radiate from the central vein PAGE 1 OF 3  MICRO LAB - CELL ORIENTATION Skeletal muscle cells (A) are multinucleated and are Elongated with blunt ends/ SHAPE located in the periphery (B). Cylindrical with blunt ends Each muscle cell is enveloped by a loose collagenous tissue known as endomysium ( C ). ARRANGEMENT Bundles/ fascicles Take note of the continuous capillary (D) su[pplying NUMBER OF NUCLEUS the muscle. The shape of each skeletal myocyte is Multi (nucleation) cylindrical with blunt ends. LOCATION OF NUCLEUS Peripheral SPINAL CORD The spinal cord is divided into white matter and the central gray matter. Within the Gray matter are the randomly arranged neurons which is the parenchyma of the organ. The skeletal myocytes (A) are elongated with blunt ends arranged in bundles The entire muscle cell is surrounded by a dense connective tissue known as epimysium (B) The skeletal myocytes are covered with perimysium (D) Neurons are stellate in shape that are haphazardly distributed within the gray matter Arranged in bundles They are mononucleated which is centrally located due to Organization the distinct nucleolus at the center, it gives a characteristic ○ Epimysium- a dense connective tissue that surrounds of “fish eye appearance” the entire cell Continuous capillaries are found scattered within the gray ○ Endomysium- a loose collagenous tissue that matter envelops each muscle cell ○ Perimysium- a connective tissue surrounding a SPINAL CORD bundle of muscle fibers PARENCHYMA Neurons/ Nerve cell SKELETAL MUSCLE SHAPE Stellate Skeletal muscle cell/ Skeletal ARRANGEMENT Haphazard/ random PARENCHYMA myocyte PAGE 2 OF 3  MICRO LAB - CELL ORIENTATION NUMBER OF NUCLEUS NUMBER OF NUCLEUS Mononucleated Mononucleated (nucleation) (nucleation) LOCATION OF NUCLEUS Central LOCATION OF NUCLEUS Central COMPACT BONE SKIN EPIDERMIS The compact bone is composed of concentrically-arranged bony lamellae referred to as osteon. The center of an osteon is the Haversian canal Keratinocytes represent the major cell type of the epidermis Nucleus is centrally located Each cell will only have one nucleus ○ The Haversian canal (HV) is surrounded by concentric lamellae where lacuna are found and inside the lacuna are the osteocytes which is the parenchyma of the compact bone ○ These osteocytes or bone cells are mononucleated with SKIN a centrally located nucleus, they are almond in shape with projections. The osteocytes possess fine PARENCHYMA Keratinocytes cytoplasmic processes that insert in the bone canaliculi SHAPE Flat or squamous COMPACT BONE ARRANGEMENT Layers/Sheets PARENCHYMA Osteocytes/Bone cells NUMBER OF NUCLEUS Mononucleated (nucleation) SHAPE Almond with projections LOCATION OF NUCLEUS Central ARRANGEMENT Concentric PAGE 3 OF 3