Epigenetics and Epigenomics
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This document defines epigenetics and epigenomics and explores their related concepts such as epigenitor, epigenetic initiator, and epigenetic maintainer. It also details the mechanisms involved in DNA methylation, histone modifications, and allelic imbalance, including X-chromosome inactivation.
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**Define the following terms: epigenetics and epigenomics:** **1. Definitions:** - - #### **Explain meaning of epigenitor, epigenetic initiator, and epigenetic maintainer by giving example of** #### **-interacting factors and level of involvement:** #### **2. Key Terms:** - - - ##...
**Define the following terms: epigenetics and epigenomics:** **1. Definitions:** - - #### **Explain meaning of epigenitor, epigenetic initiator, and epigenetic maintainer by giving example of** #### **-interacting factors and level of involvement:** #### **2. Key Terms:** - - - #### **Describe mechanism of interaction of epigenetic initiator - DNA-binding proteins and ncRNAs:** #### **3. Mechanism of Interaction:** - - - - - - - - - - #### **Describe mechanism of interaction of epigenetic maintainer -- DNA methylation, histone modification** #### **(methylation, phosphorylation, acetylation, ubiquitylation and sumoylation, histone variants);** #### **4. Epigenetic Maintainer:** - - - - - - - - - - - - - - #### **Explain allelic imbalance in gene expression - somatic rearrangement, random allelic silencing or** #### **5. Allelic Imbalance in Gene Expression:** - - - - - #### **Describe X chromosome inactivation -- molecular mechanism and its biological role;** #### **6. X Chromosome Inactivation:** - - - - #### **Describe in the level of molecular mechanism, how epigenetics and epigenomics can give an impact to** #### **human pathology (to name diseases is not requested):** #### **7. Epigenetics and Human Pathology:** - - - -
