Epigenetics and Epigenomics

**Define the following terms: epigenetics and epigenomics:** **1. Definitions:** - - #### **Explain meaning of epigenitor, epigenetic initiator, and epigenetic maintainer by giving example of** #### **-interacting factors and level of involvement:** #### **2. Key Terms:** - - - ##...

**Define the following terms: epigenetics and epigenomics:** **1. Definitions:** - - #### **Explain meaning of epigenitor, epigenetic initiator, and epigenetic maintainer by giving example of** #### **-interacting factors and level of involvement:** #### **2. Key Terms:** - - - #### **Describe mechanism of interaction of epigenetic initiator - DNA-binding proteins and ncRNAs:** #### **3. Mechanism of Interaction:** - - - - - - - - - - #### **Describe mechanism of interaction of epigenetic maintainer -- DNA methylation, histone modification** #### **(methylation, phosphorylation, acetylation, ubiquitylation and sumoylation, histone variants);** #### **4. Epigenetic Maintainer:** - - - - - - - - - - - - - - #### **Explain allelic imbalance in gene expression - somatic rearrangement, random allelic silencing or** #### **5. Allelic Imbalance in Gene Expression:** - - - - - #### **​​Describe X chromosome inactivation -- molecular mechanism and its biological role;** #### **6. X Chromosome Inactivation:** - - - - #### **Describe in the level of molecular mechanism, how epigenetics and epigenomics can give an impact to** #### **human pathology (to name diseases is not requested):** #### **7. Epigenetics and Human Pathology:** - - - -