Lecture Life Science II Cell-Cell/Cell-Matrix Connections PDF

02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl...

02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Lecture Contents Cell Cycle Cell Death Cell- Cell and Cell- Matrix Junctions Cancer 46 46 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Introduction 47 1  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl 48 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl 49 2  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl 50 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Cadherins Form a Diverse Family of Adhesion Molecules 51 3  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Cadherin-Dependent Cell–Cell Adhesion Guides the Organization of Developing Tissues 52 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Cadherin-Dependent Cell–Cell Adhesion Guides the Organization of Developing Tissues 53 4  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl 54 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl CELL–CELL JUNCTIONS Epithelial–Mesenchymal Transitions Depend on Control of Cadherins Catenins Link Classical Cadherins to the Actin Cytoskeleton 55 5  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Desmosomes Give Epithelia Mechanical Strength 56 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl 57 6  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Tight Junctions Form a Seal Between Cells and a Fence Between Plasma Membrane Domains 58 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Tight Junctions Contain Strands of Transmembrane Adhesion Proteins 59 7  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl A Gap-Junction Connexon Is Made of Six Transmembrane Connexin Subunits 60 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Selectins Mediate Transient Cell–Cell Adhesions in the Bloodstream 61 8  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Members of the Immunoglobulin Superfamily Mediate Ca2+- Independent Cell–Cell Adhesion 62 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl The Extracellular Matrix Is Made and Oriented by the Cells Within It 63 9  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Glycosaminoglycan (GAG) Chains Occupy Large Amounts of Space and Form Hydrated Gels Hyaluronan Acts as a Space Filler During Tissue Morphogenesis and Repair 64 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Collagens Are the Major Proteins of the Extracellular Matrix 65 10  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl 66 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl The Basal Lamina Is a Specialized Form of Extracellular Matrix 67 11  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Integrins Are Transmembrane Heterodimers That Link the Extracellular Matrix to the Cytoskeleton 68 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Integrins Are Transmembrane Heterodimers That Link the Extracellular Matrix to the Cytoskeleton 69 12  02.05.23 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Integrin Defects Are Responsible for Many Genetic Diseases 70 Lecture Life Science II Prof. Dr. Melanie Kappelmann- Fenzl Integrins Can Switch Between an Active and an Inactive Conformation 71 13