Unit 1, Medicinal Cheimstry 1, B Pharmacy 4th Sem, Carewell Pharma.pdf

Page 1 of 35 a a a rm rm...

Page 1 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures lP lP lP el el w w re re MEDICINAL CHEMISTRY TS Ca Ca UNTT-Ts a a a rm rm rm ha ha ha Thoduction to Medicnal Chunlst lP lP lP History dvelbpmont el el of Mudidnal Cnistry w w Phuysielegieal phuysicodhnicol re properties re in relahion Ca Ca biological action Tovizotion - Pantition (oefficien Protein binding Solubiliu bonding-Chlahm a a a -Hyddqn rm rm rm ha ha ha Bioisos erism - Optital 4 eomuical Tsomurism lP lP lP Mlabolism el el Dhwa w w re re Ca Ca ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 2 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures Inbodudim to Mudidnal Chemishy lP lP lP el el w w T is a branch of chumlsy, that re re Ca Ca intrsaction ofF orqpnic humisy, biological phomacoloq4 nd various othr Spedl speualities. a a a rm rm rm t is a disciplina thor endou ha ha ha desian dovelopmun and Symthesis ofF lP lP lP el el pharmaceuticol drugs. w w re involves ta re of existing Ca Ca also studying dnugthelr btologlcal octivit (probehies) Ond Stwdue Activity Relahionshup a a a rm rm CSAR. rm ha ha ha -MAhaism of atim lP lP lP el el U of drugs w w Synthusic of re re drugs Ca Ca SAR (STRUCTURE ACTIVITy RELATIONSHIP CHEMISTRY SEHIND DRUG ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 3 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures HiSTORY AND lP lP lP DEVELOPMENT of el el MEDICINAL CHEMISTRY w w re re Ca Ca Thu Th Onclent ivilizahons of hl chinea, t Hiudus, found to b tha ty Uud a a a thoapeutic plawls and rm rm rm Mnual Tor th ha ha ha teatemt lP lP lP also chwed CoCa uaves (lonjaiuiug el el w w Cocaiu) Cud Usud re re MUSWoms Ca Ca halludnoqus Soma natual products Us4 in histo isto Such Opium Cluchona Bavk. a a a rm rm rm ha ha ha 19M 19 cetuuy noum as ag of innovatin lP lP lP aud chwwishy) el el w w re re 1253 Hunry naed mouphint wt Ca Ca muy! iodida d Make a Mluw Aubs antl bf qualetna Aalt of Monphlua((modifted). ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 4 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures Mouphina deuvahve was uboduced as lP lP lP Cough Sedhatie in el el 1299. w w Duig re re Ca 1840 firsF vse of Syntuhic Ca Oloanic chemicals weuL iwboduced fo anauthesa duig a oom emoved lik ubous Oxide, eur and chloroforr a a a rm rm rm 186-hanbituic aud Sywhuszed as a ha ha ha ucuful nypwotic. lP lP lP 184S Salicyllc acicl el el f typuod feren w w uboducod re re Ca Ca 1899- Aspiin Was monkekd as avdipyetic wiHout Unplasut sida effus. Aifter 14 30'sduvelopmun of nw a a a rm rm dug was Spaudad geaty by Combinahnm rm ha ha ha of mudicina chmithg + xpeimntal lP lP lP phanmacolo el el w w Discovey dF re re penicillin in Ca Ca is first futibiohica w an qeatuF achieve man ( DisoN by Atexandr fumjua) ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 5 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures lP lP lP el el w w re re -lquo Ca tirs drvg fo peam Ca CancAr was nuhooun nmustand as a alkylatug agu a a a rm rm rm ha ha ha n the a?oh Certuny, John lougy lP lP lP el el Oud trlich w w Paul (OR up wsh tL re re Ca Ca recepto tuouy i maka undusad tuar dna biud o hecepton + a a a bamd on he chmcal spvctuL rm rm rm ha ha ha CombositHon. lP lP lP el el w w re re Ca Ca ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 6 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures Phusicochumical propeajies inYelotion do Biologicol adion lP lP lP el el n whidn we 2ow Yolu of SomL phycical and w w poproputes re re chomical Ca body ui biclogicol Ca achim. Physico+Chtmical Puydal * Chmlcal O1onizatin a a a Solubuli rm rm rm (3)auriion cofficient ha ha ha tHydrogun bonding lP lP lP Botin Bvding el el Chulahim w w re Sio Sioisoteism re Ca Ca Cphtal 0vd Gtomuical isomerism O Tonisahion tis a phocoAs buy whh on aom/molewles acqvie a a a rm rm ngaive Or pociive chag by qainlu or lbsing rm eluctrms. | ha ha ha T Thu 1esulig thangd atom/mouuuls (ollLd an ion. lP lP lP Tomizom A/A e release e) A* Cahion) el el A ctabu) w w Uwioizd (ionizud) eactept A (Anin re re (nm-ion) fomi Ca Ca Na NatC C (CHh CooH CH c007+H etc- ek ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 7 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures ToNIZATION Vnmzed upopilie lP lP lP TOnj zd- Hydsophullc el el w w re Tutake re Dwuing hould be (UnlbnlzedSalt (rual) Ca Ca Oug Absophm - Drug teadhs ind ( blood a a a rm rm rm Hydnophlic ha ha ha Dnq should be (hydnophl lP lP lP for tuii el el bL (Tonstd w MUsF w re re Ca Ca Oisibuhom Yva rebs jnjd (celA/hissul or Ck ofahm upophiuly'c Cpluesphalipiá) a a a rm rm Dr shovld ba (ipopilic) rm ha ha ha -for this lP lP lP MUs MUsF ba (unionjzud el el w w need t0 roSScell-munbrau re re Mads up wn Ca Ca (plospho i pids) dwa MUS upopulic in be upophilut nat ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 8 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures Kelaon to iologial achtons lP lP lP Rolu of ionizahtom in Biological aion(otniuy) in humans (amimals el el play an w w inmportan role in phamaozinihu. re re Ta move men off drugs tn body , Ca Ca. Phaymacointiu involves ADME (Abtorptíom distibuhm, mtabolism and Exurhion). A Gicod balan of Ionized- Unlonzed" form 1s better for phaumacokinic a a a rm rm rm Uhionizud form of drvg - pophidie nau ha ha ha ovdzd form of dug CHydhopkilic) natue lP lP lP Tonized form impart q0d waler Colubilutito t drug el el whidh is ecutial food good binding interation of w w drvg wih is receptor. re drug to re celA Ca Ca whils uuonizidorm upA fa CroSS MembranA Tha drug must b weakly aúdic weaely basic. T Thu daqee of dissouatim Cimizohon) Can b Calwlated a a a rm rm VSiW hendurcon hasdbaldth tquahn. rm ha ha ha PH=pka+ loq TonlzdJ -fo an auLa lP lP lP Cunionid] el el pH pka+ loq (Unioni zud w w ioni zd) re re Ca Ca AtcuthHc hase eg. aud CHCodH (rugaud ChCooH - Ch cod +H (Umzed /uon-jamlzd) C Tmiz4 ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 9 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures Solubulhiiy lP lP lP Thd Tha Maximum amount of Solule partida whidh on el el dissolved in pr loom/gm of solvent is callud t w w ba dru a re re "sdvbility Ca of given tmperokue Ca dissolved Soluts hCsodulin) (Solven J Tt dupends on tunatUk" of solu and solvent as well as a a a 'pssurt"(Huduophila't f ipophilic. rm rm rm Heperatue pH ha ha ha Th aldms 0und Moltculus of al orqani subijanu ak held lP lP lP toquthu by various Typuy of bornd'(eq tuydiegn bond, el el dipola -dipole, Tonic bomd ek-) w w re re Mhod to iprove Solubilty of drugs Ca Ca Aller L sructun of Molwlu Us oF Co-Solvtnts (€Hhancol, elt--) Addikim of surfactan Combxohio. a a a Impotmt (Rehationp biclogital ftetin) rm rm dupends rm Sioavailielu of Mawly on hir soluodi ha ha ha drug in 4 glven Solvent Sycem. lP lP lP scluion" bufdr it can el el Drug CSoluk) MUS bin s atiu w w AnoW absorbed y biologital membranL and re re solution intrat witm DrugsMUSt b in Ca Ca receptors. ma ma ma ar ar ar www.carewellpharma.in (free notes) Ph Ph Ph visit website to download free pdf notes  Page 10 of 35 a a a rm rm rm Carewell Pharma - A family of learning ha ha ha search CAREWELL PHARMA on Youtube, Watch Free Video lectures Paatiionm Coctfitient lP lP lP TF is th vaio of Conwtraion of a compourds el el wo ar equli brium. w w (druq) in ti phasus re re Solu upophili (ogevc] Ca Ca -Hyd«ophulit. Cuonle what, = pauitim coefficteuF ipophilic (oganlt pha] Co= Conwnratien of dug in Concovtrohion of drug in hydrophlic Caqutous phase] a a a C rm rm rm Tnpotne (euahn to biologicol actiuuti) ha ha ha drug absorphon and distvibuitm. lP lP lP affe c Combination wih t pka to qunrally ued in el el Tis drug in biologitol Sysem w w of prectct tu aisbibuhm re Sin, Bjological MAmbran an ipophilic in natu re Ca Ca is dire cHy velakd t So, th ra of dng ransfe th Lipophilicity of m molecolu Matun of dug Ha is Helb' Rn0 t Solubilit (bicovalibin )D- Lipophilicfor is a a a Hydropulit o rm rm Sepanahion muHhod rm hrough ha ha ha CO miaswld lP lP lP Value oF ipophulic el el drug K>L,thin w w hydrophulu. K