Synapses and synaptic transmission - Tagged.pdf

Add Portrait Photo Institute of Psychiatry, Psychology & Neuroscience 2023 - 2024 Dr Philip R Holland MBBS: Physiology & Anatomy of Systems Synapses & synaptic transmission. DD/Mont...

Add Portrait Photo Institute of Psychiatry, Psychology & Neuroscience 2023 - 2024 Dr Philip R Holland MBBS: Physiology & Anatomy of Systems Synapses & synaptic transmission. DD/Month/YYYY Professor/Dr: Topic title: Learning Outcomes 3. Synapse/neuromuscular junction Explain the key distinctions between electrical (e.g. heart) and chemical (e.g. neural synaptic) transmission Describe the main structural features of the neuromuscular junction (NMJ) Explain the mechanism of quantal release of transmitters Explain the basis of miniature end plate potential (MEPPs) and end plate potentials (EPPs) Explain the distinction between temporal and spatial summation DD/Month/YYYY Professor/Dr: Topic title: Concept of the Synapse Two key points: Discovery that pre- and post-synaptic neurons are separated by a gap (synaptic cleft, Sherrington, early 1900’s). Synaptic transmission across the cleft involves chemical transmitters (neurotransmitters) or neuromodulators (Loewi, 1920’s). DD/Month/YYYY Professor/Dr: Topic title: Gap Junction Communication Gap Junctions DD/Month/YYYY Professor/Dr: Topic title: Synapses DD/Month/YYYY Professor/Dr: Topic title: Types of Synapses DD/Month/YYYY Professor/Dr: Topic title: Synapses DD/Month/YYYY Professor/Dr: Topic title: Neuronal Communication Dendrites Cell Body Axon DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication Ca2+ Ca 2+ Ca2+ Resting synapse AP arrives, V-gated Ca2+ channels open DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication Ca2+ entry triggers exocytosis NT diffuses across the of synaptic vesicle content synaptic cleft and activates DD/Month/YYYY Professor/Dr: Topic title: postsynaptic cell Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title:  Subthreshold Postsynaptic Response Current passing electrode Pipette filled with ACh Record Vm DD/Month/YYYY Professor/Dr: Topic title: Graded Potentials Stimulus + Na Wave of depolarization throughout the cytoplasm Potential will diminish quickly DD/Month/YYYY Professor/Dr: Topic title: Propagation of the Signal 4 mm DD/Month/YYYY Professor/Dr: Topic title:  Suprathreshold Postsynaptic Response Current passing electrode Pipette filled with ACh DD/Month/YYYY Professor/Dr: Topic title: Propagation of the Action Potential DD/Month/YYYY Professor/Dr: Topic title: Triggering an Action Potential Presynaptic Postsynaptic Axon Hillock No AP AP DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Drugs & Neurotransmission DD/Month/YYYY Professor/Dr: Topic title: Reduced Vesicle Release Due to (Bernard Katz): Low calcium High magnesium Curare (poison) Botox DD/Month/YYYY Professor/Dr: Topic title: Reduced Vesicle Release Due to (Bernard Katz): Low calcium High magnesium Curare (poison) Botox DD/Month/YYYY Professor/Dr: Topic title:  Mini-Endplate Potentials Current passing electrode Pipette filled with ACh Low calcium High magnesium Curare DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Integration of EPSP’s & IPSP’s EPSP’s and IPSP’s are sub threshold events which determine whether a cell will reach threshold to fire an action potential – or not. EPSP’s add to generate depolarisation (more likely to fire an action potential). IPSP’s add to generate hyperpolarisation (less likely to fire an action potential). EPSP’s and IPSP’s act to cancel each other out. DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Integration of EPSP’s & IPSP’s EPSP: excitatory postsynaptic potential. IPSP: inhibitory postsynaptic potential. DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Spatial Summation DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Temporal Summation DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Temporal Summation DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Integration of EPSP’s & IPSP’s EPSP’s and IPSP’s are sub threshold events which determine whether a cell will reach threshold to fire an action potential – or not. EPSP’s add to generate depolarisation (more likely to fire an action potential). IPSP’s add to generate hyperpolarisation (less likely to fire an action potential). EPSP’s and IPSP’s act to cancel each other out. DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Integration of EPSP’s & IPSP’s EPSP: excitatory postsynaptic potential. IPSP: inhibitory postsynaptic potential. DD/Month/YYYY Professor/Dr: Topic title: The Knee Jerk Reflex: Communicating Across Networks Muscle Spindle DD/Month/YYYY Professor/Dr: Topic title: The Knee Jerk Reflex: Communicating Across Networks DD/Month/YYYY Professor/Dr: Topic title: [email protected] DD/Month/YYYY Professor/Dr: Topic title: