Synapses and Synaptic communication 2023-2024 PDF

Institute of Psychiatry, Psychology & Neuroscience 2023-2024 Dr Philip R Holland 4BBY1030 Cell Biology & Neuroscience Neurons and Neuronal communication: Synapses & synaptic transmission. DD/Month/YYYY Professor/Dr: Topic title: Concept of the Synapse Two key points: Discovery that pre- and post-syn...

Institute of Psychiatry, Psychology & Neuroscience 2023-2024 Dr Philip R Holland 4BBY1030 Cell Biology & Neuroscience Neurons and Neuronal communication: Synapses & synaptic transmission. DD/Month/YYYY Professor/Dr: Topic title: Concept of the Synapse Two key points: Discovery that pre- and post-synaptic neurons are separated by a gap (synaptic cleft, Sherrington, early 1900’s). Synaptic transmission across the cleft involves chemical transmitters (neurotransmitters) or neuromodulators (Loewi, 1920’s). DD/Month/YYYY Professor/Dr: Topic title: Types of Synapses DD/Month/YYYY Professor/Dr: Topic title: Neuronal Communication Dendrites Cell Body Axon DD/Month/YYYY Professor/Dr: Topic title: Gap Junction Communication Gap Junctions DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication Ca2+ Ca2+ Resting synapse DD/Month/YYYY Professor/Dr: Topic title: Ca2+ AP arrives, V-gated Ca2+ channels open Synaptic Communication Ca2+ entry triggers exocytosis of synaptic vesicle content DD/Month/YYYY Professor/Dr: Topic title: NT diffuses across the synaptic cleft and activates postsynaptic cell Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Graded Potentials Stimulus + Wave of depolarization throughout the cytoplasm Na Potential will diminish quickly DD/Month/YYYY Professor/Dr: Topic title: Triggering an Action Potential Presynaptic Postsynaptic Axon Hillock No AP DD/Month/YYYY Professor/Dr: Topic title: AP Synaptic Communication: Spatial Summation DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Temporal Summation DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Temporal Summation DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Integration of EPSP’s & IPSP’s EPSP: excitatory postsynaptic potential. IPSP: inhibitory postsynaptic potential. DD/Month/YYYY Professor/Dr: Topic title: Synaptic Communication: Integration of EPSP’s & IPSP’s EPSP’s and IPSP’s are sub threshold events which determine whether a neuron will reach threshold to fire an action potential – or not. EPSP’s add to generate depolarisation (more likely to fire an action potential). IPSP’s add to generate hyperpolarisation (less likely to fire an action potential). EPSP’s and IPSP’s act to cancel each other out. DD/Month/YYYY Professor/Dr: Topic title: Receptor Types Ionotropic Receptors: Ligand activated ion channels Fast acting, opens and closes quickly Generates post-synaptic potential EPSP: Na+, IPSP: K+, Cl Metabotropic Receptors: Combined to a G-protein Slower acting Generates a longer-lasting more varied response DD/Month/YYYY Professor/Dr: Topic title: Receptor Types DD/Month/YYYY Professor/Dr: Topic title: Frequency Coding DD/Month/YYYY Professor/Dr: Topic title: Frequency Coding Graded Potential DD/Month/YYYY Professor/Dr: Trigger Zone Topic title: Action Potential How can we use this? Blue light Yellow light Open (cations) flow in Open (Cl-) flow in depolarize DD/Month/YYYY Professor/Dr: hyperpolarize Topic title: The Knee Jerk Reflex: Communicating Across Networks DD/Month/YYYY Professor/Dr: Topic title: The Knee Jerk Reflex: Communicating Across Networks DD/Month/YYYY Professor/Dr: Topic title: [email protected] DD/Month/YYYY Professor/Dr: Topic title: