Student Top 300 List (2023-24) PDF

cf Amiodarone Brand Name (all years) Cordarone, Pacerone Therapeutic Class (P1's Associated Course only) ICARE-Cardiology Antiarrhythmic Pharmacologic Class (P2's and P3's) Vaughn Williams Class III Antiarrhythmic Common Route(s) of Administration Contraindications (P2's and P3's) (P2's and P3's...

cf Amiodarone Brand Name (all years) Cordarone, Pacerone Therapeutic Class (P1's Associated Course only) ICARE-Cardiology Antiarrhythmic Pharmacologic Class (P2's and P3's) Vaughn Williams Class III Antiarrhythmic Common Route(s) of Administration Contraindications (P2's and P3's) (P2's and P3's) Oral, Intravenous second or third-degree heart block; hypersensitivity to iodine Amlodipine Norvasc ICARE-Cardiology Antihypertensive Dihydropyridine Calcium Channel Blocker Oral None Apixaban Eliquis ICARE-Cardiology Anticoagulant Factor Xa Inhibitor Oral Atorvastatin Lipitor ICARE-Cardiology Antihyperlipidemic HMG-CoA Reductase Inhibitor (Statin) Oral Bivalirudin Angiomax ICARE-Cardiology Anticoagulant Direct Thrombin Inhibitor Intravenous active bleeding pregnancy, breastfeeding, unexplained elevation of serum transaminases active bleeding Bumetanide Bumex ICARE-Cardiology Diuretic Loop Diuretic Oral, Intravenous Carvedilol Coreg ICARE-Cardiology Antihypertensive Non-Selective Beta Blocker Oral Chlorthalidone Hygroton, Thalitone ICARE-Cardiology Antihypertensive/Diuretic Thiazide Diuretic Oral, Intravenous Clopidogrel Plavix ICARE-Cardiology Antiplatelet P2Y12 Inhibitor Oral Colesevelam Welchol ICARE-Cardiology Antihyperlipidemic Bile Acid Sequestrant Oral Dabigatran Pradaxa ICARE-Cardiology Anticoagulant Direct Thrombin Inhibitor Oral Digoxin Lanoxin ICARE-Cardiology Inotropic Agent/Rate Controller Cardiac Glycoside Diltiazem Cardizem ICARE-Cardiology Antihypertensive Non-Dihydropyridine Calcium Channel Blocker Oral, Intravenous Doxazosin Cardura ICARE-Cardiology Antihypertensive Alpha-1 Adrenergic Blocker Oral Enoxaparin Lovenox ICARE-Cardiology Anticoagulant Low Molecular Weight Heparin Subcutaneous Oral, Intravenous anuria, severe electrolyte depletion second or third degree heart block; decompensated heart failure; bronchospastic conditions anuria; sulfonamide hypersensitivity active bleeding; avoid omeprazole and esomeprazole due to diminished antiplatelet effectand hypertriglyceridemia-induced history of bowel obstruction pancreatitis; triglycerides > 300 mg/dL active bleeding ventricular fibrillation second or third degree heart block; heart failure with reduced ejection fraction Clinically Relevant Adverse Reactions Boxed Warnings and Precautions (P2's and P3's) (ADRs) (P2's and P3's) pulmonary IV: bradycardia, hypotension | ORAL: pulmonary toxicity, hepatoxicity, fatal arrhythmias fibrosis, hepatotoxicity, dysfunction, hypotension, dizziness, thyroid peripheral edema, increased risk for hematomas in patients undergoing gingival hyperplasia, headache bleeding, bruising neuraxial anesthesia; avoid in patients with mechanical hepatotoxicity, muscle symptoms (i.e. myalgia, myopathy) bleeding hyponatremia, hypokalemia, hyperuricemia, sulfonamide hypersensitivity hypomagnesemia, hypocalcemia, acute renal bradycardia, hypotension hyponatremia, hypokalemia, hyperuricemia, hypomagnesemia not recommended in CYP2C19 poor metabolizers bleeding constipation, gastrointestinal upset, avoid in patients with mechanical heart valves; avoid in hypertriglyceridemia bleeding, GI upset/dyspepsia severe renal impairment hypokalemia may increase toxicity; narrow therapeutic bradycardia, visual disturbances, anorexia, index nausea/vomiting bradycardia, hypotension, gingival hyperplasia Zetia ICARE-Cardiology Antihyperlipidemic Cholesterol Absorption Inhibitor Oral None Fenofibrate Lofibra, Tricor, Trilipix ICARE-Cardiology Antihyperlipidemic Fibrate Oral active liver disease, severe renal impairment, breastfeeding ICARE-Cardiology Diuretic Loop Diuretic Oral, Intravenous anuria, severe electrolyte depletion Anticoagulant Unfractionated Heparin Intravenous, Subcutaneous active bleeding; history of heparin induced thrombocytopenia Hydrochlorothiazide (HCTZ) no brand name ICARE-Cardiology Antihypertensive/Diuretic Thiazide Diuretic Oral anuria; sulfonamide hypersensitivity avoid in severe renal impairment Hydralazine Apresoline ICARE-Cardiology Antihypertensive Vasodilator Oral, Intravenous Isosorbide mononitrate Imdur ICARE-Cardiology Antianginal Nitrate Oral increased intracranial pressure longer durations), hypotension, reflexive headache, dizziness Labetalol Normodyne ICARE-Cardiology Anithypertensive Oral, Intravenous mitral valve rheumatic disease, coronary artery disease concurrent use with phosphodiesterase-5 (PDE-5) inhibitors (i.e. sildenafil) riociguat second or thirdordegree heart block; decompensated heart avoid concomitant angiotensin receptor blockers (ARBs) avoid concomitant ACE inhibitors bradycardia, hypotension hypotension, hyperkalemia, increased SCr, cough hypotension, hyperkalemia, increased SCr Cozaar ICARE-Cardiology Antihypertensive Lopressor, Toprol XL ICARE-Cardiology Antihypertensive Selective Beta Blocker Oral, Intravenous Nifedipine Adalat, Procardia ICARE-Cardiology Antihypertensive Dihydropyridine Calcium Channel Blocker Oral Nitroglycerin Nitro-Dur, Nitrostat ICARE-Cardiology Antianginal Nitrate Sublingual, Topical, Intravenous Norepinephrine Levophed ICARE-Cardiology Vasopressor Alpha and Beta Adrenergic Agonist Intravenous Omega-3-Acid Ethyl Esters Lovaza ICARE-Cardiology Antihyperlipidemic Omega-3-Fatty Acid Oral Prasugrel Effient ICARE-Cardiology Antiplatelet Rivaroxaban Xarelto ICARE-Cardiology Prinivil, Zestril ICARE-Cardiology Antihypertensive Oral Oral P2Y12 Inhibitor Oral Anticoagulant Factor Xa Inhibitor Oral Rosuvastatin Crestor ICARE-Cardiology Antihyperlipidemic Sacubitril/Valsartan Entresto ICARE-Cardiology Heart Failure Medication Simvastatin Zocor ICARE-Cardiology Antihyperlipidemic Spironolactone Aldactone ICARE-Cardiology Antihypertensive/Diuretic Ticagrelor Brilinta ICARE-Cardiology Antiplatelet HMG-CoA Reductase Inhibitor (Statin) Angiotensin Receptor-Neprilysin Inhibitor (ARNI) HMG-CoA Reductase Inhibitor (Statin) Mineralocorticoid (Aldosterone) Receptor Antagonist P2Y12 Inhibitor Verapamil Calan ICARE-Cardiology Antihypertensive Non-Dihydropyridine Calcium Channel Blocker Oral, Intravenous Warfarin Coumadin, Jantoven ICARE-Cardiology Anticoagulant Vitamin K Antagonist Oral Alprazolam Xanax ICARE-NeuroPsych Sedative-hypnotic Benzodiazepine Oral Tricyclic Antidepressant (TCA) Oral Oral Oral Oral Oral Amitriptyline Elavil ICARE-NeuroPsych Antidepressant Aripiprazole Abilify ICARE-NeuroPsych Strattera ICARE-NeuroPsych Buprenorphine/Naloxone Suboxone, Zubsolv ICARE-NeuroPsych Bupropion Wellbutrin ICARE-NeuroPsych Buspirone Buspar ICARE-NeuroPsych Antipsychotic Second-generation Antipsychotic (SGA) Attention-deficit/hyperactivity Serotonin-norepinephrine Reuptake Inhibitor disorderuse (ADHD) treatment (SNRI) Opioid disorder medication Combination Opioid Partial Agonist and assisted therapy Opioid Antagonist Norepinephrine-Dopamine Reuptake Inhibitor Antidepressant (NDRI) Antidepressant 5-HT1A Partial Agonist Oral, Intramuscular Atomoxetine Carbamazepine Tegretol ICARE-NeuroPsych Antiseizure drug Oral Sodium Channel Blocker Oral Oral Sublingual Oral Oral Citalopram Celexa ICARE-NeuroPsych Antidepressant Selective Serotonin Reuptake Inhibitor (SSRI) Oral Onfi, Sympazan ICARE-NeuroPsych Sedative-hypnotic Benzodiazepine Oral Clonazepam Klonopin ICARE-NeuroPsych Sedative-hypnotic Benzodiazepine Oral Clonidine Catapres ICARE-NeuroPsych Antihypertensive Oral, Transdermal Desvenlafaxine Pristiq ICARE-NeuroPsych Antidepressant Alpha-2 Adrenergic Agonist Serotonin-norepinephrine Reuptake Inhibitor (SNRI) Dexmethylphenidate Focalin ICARE-NeuroPsych Attention-deficit/hyperactivity disorder (ADHD) treatment Psychostimulant Oral Diazepam Valium ICARE-NeuroPsych Sedative-hypnotic, antiseizure drug Benzodiazepine Oral, Intramuscular, Intravenous, Per Rectum Contraindicated in patients with myasthenia gravis, severe respiratory insufficiency, severe hepatic insufficiency, sleep apnea syndrome increased intracranial pressure; potential for severe hypotension ensure proper needle/catheter placement and infuse bradycardia, hypotension hypotension, peripheral edema, gingival hyperplasia hypotension, dizziness Concomitant use with opioids may result in profound sedation, respiratory depression, coma, and death; risk of addiction, abuse, and misuse; may increase the risk of congenital malformations and other developmental abnormalities Sedation/drowsiness, impaired coordination, memory impairment, dysarthria, muscle weakness Divalproex Depakote ICARE-NeuroPsych Antiseizure drug GABAergic, Sodium Channel Blocker Oral, Intravenous Doxepin Sinequan, Silenor ICARE-NeuroPsych Antidepressant Tricyclic Antidepressant (TCA) Oral Use with monoamine oxidase inhibitors (MAOIs), untreated narrow angle glaucoma, severe urinary retention Duloxetine Cymbalta ICARE-NeuroPsych Antidepressant Serotonin-norepinephrine Reuptake Inhibitor (SNRI) Oral Use with monoamine oxidate inhibitors (MAOIs) Escitalopram Lexapro ICARE-NeuroPsych Antidepressant Selective Serotonin Reuptake Inhibitor (SSRI) Oral Use with monoamine oxidase inhibitors (MAOIs); use with pimozide Eszopiclone Lunesta ICARE-NeuroPsych Sedative-hypnotic Z-hypnotic Contraindicated in patients who have experienced complex sleep behaviors after taking eszopiclone Fluoxetine Prozac, Sarafem ICARE-NeuroPsych Antidepressant Selective Serotonin Reuptake Inhibitor (SSRI) Oral increased risk of suicidal thinking and behavior in patients aged 24 and younger; may precipitate serotonin syndrome; may increase the risk of Not approved for children younger than 7; use with monoamine bleeding events; may precipitate a mixed/manic oxidase inhibitors (MAOIs); use with pimozide; use with episode in patients with bipolar disorder; may cause thioridazine discontinuation syndrome; may trigger an angle closure glaucome attack; may cause hyponatremia; may cause sexual dysfunction; may cause anxiety, nervousness, or insomnia; may cause weight loss Gabapentin Neurontin, Gralise ICARE-NeuroPsych Antiseizure drug Alpha2-delta Calcium Channel Blocker Oral Patients with hypersensitivity to the drug or its ingredients; should not be abruptly discontinued because of the possibility of increasing seizure frequency in patients with epilepsy Guanfacine Intuniv ICARE-NeuroPsych Antihypertensive Alpha-2 Adrenergic Agonist Oral None Lacosamide Lamotrigine Vimpat Lamictal ICARE-NeuroPsych ICARE-NeuroPsych Antiseizure drug Antiseizure drug Sodium Channel Blocker Sodium Channel Blocker Oral, Intravenous Oral periodic serum drug concentrations needed do not crush/chew long-acting dosage forms take early in the day to avoid nocturia take early in the day to avoid nocturia immediate release formulations must be admiinstered twice daily ~7 hours apart to allow for nitrate-free interval that prevents tolerance avoid abrupt discontinuation avoid abrupt discontinuation; Do not crush or chew extended release products, but may cut XL tablet in half into vein in if possible to avoid extravasation use large in caution patients with known fish/shellfish allergy; may increase bleedingwith riskainhistory patients not recommended in patients of on Should not be administered to patients with hepatic disease or significant hepatic dysfunction, patients known to have Risk of hepatotoxicity especially in children less than mitochondrial disorders caused by mutations in mitochondrial age 2; avoid in women of childbearing age due to risk Nausea/vomiting, sedation/somnolence, DNA polymerase γ, patients with known hypersensitivity to the of major congenital malformations, particularly neural increased appetite/weight gain, tremor, alopecia drug, patients with known urea cycle disorders, or woman of tube defects; may cause life-threatening pancreatitis childbearing potential unless other medications have failed to provide adequate symptom control Oral administer with meals; administer 4 hours before/after medications and vitamins keep in original container; do NOT open capsules sublingual formulation only used as needed for acute angina relief- call 911 if angina is not relieved or worsens 3-5 minutes after the FIRST sublingual dose cardiac arrhythmia, peripheral ischemia eructation (burping), dyspepsia, taste perversion, None take with meals elevated LDL active bleeding; prior history of stroke bleeding avoid NSAIDS, Stop taking at least 7 days prior to elective surgery bleeding orrisk agefor > hematomas 75 years increased in patients undergoing avoid concomitant use of NSAIDS; avoid concomitant use of combined inducers of both CYP3A4 and Pactive bleeding bleeding, bruising neuraxial anesthesia; avoid in patients with gp; doses > 15 mg should be taken with food pregnancy, breastfeeding, unexplained elevation of serum hepatotoxicity, muscle symptoms (i.e. myalgia, none limit alcohol consumption transaminases myopathy) history of angioedema, pregnancy, concomitant ACEIs or discontinue ACEI's at least 36 hours prior to starting avoid NSAIDS and only use potassium supplements under a doctors supervision; avoid food/salt hypotension, hyperkalemia, increased SCr aliskiren sacubitril/valsartan substitutes high in potassium pregnancy, breastfeeding, unexplained elevation of serum hepatotoxicity, muscle symptoms (i.e. myalgia, none avoid excessive grapefruit juice and alcohol intake transaminases; Avoid Strong CYP 3A4/3A5 inhibitors myopathy) anuria, acute renal insufficiency, hyperkalemia none hyperkalemia, hyponatremia, gynecomastia Avoid alcohol and NSAIDS and foods/salt substitutes high in potassium Avoid NSAIDS, do not take doses of aspirin > 100 mg/day, stop taking at least 5 days prior to elective active bleeding avoid aspirin doses > 100 mg/day bleeding, dyspnea second or third degree heart block; heart failure with reduced hypotension, bradycardia, constipation, gingival surgery None Do not crush or chew extended release products; avoid grapefruit juice ejection fraction hyperplasia use caution when using concomitantly with CYP2C9 bleeding, bruising, purple toe syndrome (rare but consistent diet of vitamin K containing foods; Avoid alcohol; avoid NSAIDS and other drugs that can active bleeding, pregnancy inhibitors serious) increase bleeding riskstop abruptly without talking to your doctor, as you may experience significant Use with strong CYP3A inhibitors (e.g., ketoconazole, May impair respiratory function (especially with Sedation/drowsiness, impaired coordination, Avoid alcohol; do not itraconazole) except ritonavir opioids or severe pulmonary disease); may leadinto memory impairment, dysarthria withdrawal seizures); do not take doctor more than prescribed Use with monoamine oxidase inhibitors (MAOIs), use with Increased risk of suicidal thinking and behavior Anticholinergic side effects (constipation, Do not stop(including abruptly without talking to your as you may experience significant withdrawal; take at Increased risk24 of death for elderly dementiacisapride, and during the acute recovery phase following patients aged and younger; maywith precipitate mania Extrapyrammidal xerostomia, mydriasis, urinary retention); bedtime if taking once daily to minimize sedation; your doctor ifcholesterol, you have any changes mood or symptoms (especially Antipsychotics can increase the risk of high blood contact sugar and diabetes, and weight in gain; contact None related psychosis; increased risk of suicidal thinking Increased risk of suicidal ideation in short-term restlessness/akathisia), nausea/vomiting, yournot doctor you notice any talking abnormal movements, thismay may be the sign of a potentially irreversible Use with monoamine oxidase inhibitors (MAOIs), narrow angle Nausea/vomiting, hypertension and tachycardia, Do stop ifabruptly without to your doctor asas you experience significant withdrawal; contact studies in children or adolescents with attentionglaucoma, pheochromocytoma, and severe cardiovascular decreased appetite, hyperhidrosis your doctor have changes in mood or thoughts monitor growthuntil regularly (in children) Risk of addiction, abuse, and misuse; risk of lifeWait at leastif1you hour afterany administration to brush teeth; do of notsuicide; eat or drink anything formulation has None Constipation, nausea, oral hypoesthesia Increased risk of suicidal thinking and behavior in threatening central nervous system (CNS) and completely dissolved; use other than as prescribed precipitate withdrawal Seizure disorder; current or prior diagnosis of bulimia or Separate doses by at least 6 (immediate release) ormay 8 (sustained release) hours; Do not take close to Anorexia, dry mouth, sweating, tremor, insomnia patients aged 24 and younger; may cause seizures; anorexia nervosa; abrupt discontinuation of alcohol, bedtime to prevent insomnia; contact your doctor if you have any changes in mood or thoughts of suicide Hypertension when used with a monoamine oxidase Take scheduled, not as needed or "PRN"; contact your doctor if you have any changes in mood or Use with monoamine oxidase inhibitors (MAOIs) Dizziness, nausea, headache, nervousness inhibitor (MAOI); potentially life-threatening serotonin Dizziness, drowsiness/somnolence, thoughtsyour of suicide History of bone marrow supression, use with monoamine May cause serious and sometimes fatal dermatologic Contact doctor if you notice any unexpected rashes, especially with irritated eyes, sore throat, nose, oxidase (MAOIs), use with nefazodone, use with with reactions, including toxic epidermal necrolysis unsteadiness/ataxia, nausea/vomiting, muscle aches, and/orwithout fever; talking Contacttoyour you notice unexpected bruising, experience fatigue Use withinhibitors monoamine oxidase inhibitors (MAOIs); use Increased risk of suicidal thinking and behavior(TEN) in Nausea/vomiting, sexual dysfunction, serotonin Do not stop abruptly yourdoctor doctorifas you may any experience significant withdrawal; contact Use withaged opioids result in profound sedation, pimozide; hypersensitivity to citalopram or escitalopram patients 24 may and younger; may cause dosesyndrome (rare), dose-related your doctor if you havestop anyabruptly changeswithout in mood or thoughts of suicide; maymay takeexperience at least 4-6significant weeks for onset Sedation/drowsiness, impairedQT-prolongation coordination, Avoid alcohol; do not talking to your doctor, as you None respiratory depression, coma, and death; risk of constipation, dysarthriaimpaired coordination, withdrawal (including do not take talking more than prescribed Clinical or biochemical evidence of significant liver disease, Caution against engaging in hazardous occupations Sedation/drowsiness, Avoid alcohol; do notseizures); stop abruptly without to your doctor, as you may experience significant Contraindicated in patients with a history of a hypersensitivity acute narrow angle glaucoma requiring mental alertness, such as operating memory impairment, dysarthria, paradoxical withdrawal seizures); not take more than hypertension; prescribed take at bedtime if taking once daily May cause dose-related decreases in blood pressure Sedation/somnolence, fatigue/lethargy, Do not stop(including abruptly as you maydo experience rebound reaction to clonidine and heart rate; may causethinking somnolence and sedation; hypotension and bradycardia, contact dermatitis (andnot if taking split doses, take largertodose night)as toyou minimize sedation significant withdrawal; contact Hypersensitivity to desvenlafaxine; use with monoamine Increased risk of suicidal and behavior in Nausea/vomiting, dry mouth, decreased appetite Do stop abruptly without talking your at doctor may experience oxidase inhibitors (MAOIs) patients aged 24 and younger; may precipitate and weight loss, insomnia, hyperhidrosis your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset Caution if history of drug dependence or alcoholism; may cause sudden death in children and adolescents with structural cardiac abnormalities or other serious heart problems; may cause an increase in blood pressure and heart rate; may exacerbate symptoms of behavior disturbance and thought disorder in Marked anxiety, tension, and agitation; in patients with patients with a preexisting psychotic disorder; may glaucoma; in patients with motor tics or with a family history or Decreased appetite and weight loss, insomnia, Monitor growth regularly (in children); contact your doctor if you have any changes in mood or thoughts of cause a mixed/manic episode in bippolar disorder diagnosis of Tourette’s syndrome; during treatment with nausea/vomiting, headache, jittery suicide; do not take more than prescribed patients; may cause aggressive behavior or hostility; monoamine oxidase inhibitors (MAOIs) may cause suppression of growth in children; may lower the seizure threshold in patients with prior history of seizures; may cause priapism; may cause peripheral vasculopathy, including Raynaud’s phenomenon; may cause difficulties with accommodation and blurring of vision Clobazam Oral avoid NSAIDs, Stop taking at least 5 days prior to elective surgery rotate injection sites muscle symptoms esp. whenhyperuricemia, used with statins; hyponatremia, hypokalemia, hypomagnesemia, hypocalcemia, acute renal bleeding, thrombocytopenia hyponatremia, hypokalemia, hyperuricemia, hypomagnesemia lupus-like syndrome (with higher doses and ICARE-Cardiology Losartan take early in the day to avoid nocturia for initial doses avoid tasks that requiremental alertness (e.g. operating machery or driving) used with statins sulfonamide hypersensitivity Lasix Metoprolol take with meals; avoid abrupt discontinuation bleeding, thrombocytopenia diarrhea, elevated transaminases (esp. with statins) transamninases, increased risk of elevated no brand name Lisinopril take early in the day to avoid nocturia not recommended in moderate to severe hepatic impairment increased risk for hepatotoxicity when cholelithiasis; Furosemide failure; bronchospastic conditions concomitant aliskiren, pregnancy, history of angioedema, coadministration within 36 hours of switching to/from pregnancy, concomitant aliskiren second or third degree heart block; decompensated heart failure None concurrent use with phosphodiesterase-5 (PDE-5) inhibitors (i.e. sildenafil) or riociguat None avoid excessive grapefruit juice and alcohol intake hypotension Heparin Non-selective Beta Blocker Angiotensin Converting Enzyme (ACE) Inhibitor Angiotensin II Receptor Blocker (ARB) avoid concomitant use of NSAIDs, avoid concomitant use of combined inducers of both CYP3A4 and P-gp initial doses may cause CNS depressions active bleeding; history of heparin induced thrombocytopenia Ezetimibe Counseling Points (P2's and P3's) PO: avoid sun exposure/use sunblock to avoid photosensitivity Increased risk of suicidal thinking and behavior in patients aged 24 and younger; parasomnias; central nervous system depression increased risk of suicidal thinking and behavior in patients aged 24 and younger; risk of hepatotoxicity; may cause serotonin syndrome; increased risk of bleeding; severe skin reactions; discontinuation syndrome; syncope; mania/hypomania; seizures; increased blood pressure; may trigger angle-closure glaucoma increased risk of suicidal thinking and behavior in patients aged 24 and younger; may precipitate serotonin syndrome; may increase the risk of bleeding events; may precipitate a mixed/manic episode in patients with bipolar disorder; may cause discontinuation syndrome; may trigger an angle closure glaucome attack; may cause hyponatremia; may cause sexual dysfunction Avoid alcohol; do not stop abruptly without talking to your doctor, as you may experience significant withdrawal (including seizures); do not take more than prescribed May cause severe birth defects, so use reliable birth control (females of childbearing age); contact your doctor if you notice severe stomach pain and vomiting as this may be a sign of a rare but serious side effect called pancreatitis; contact your doctor if you notice signs of liver problems such as yellow skin or eyes, dark urine, and stomach pain Anticholinergic side effects (constipation, xerostomia, mydriasis, urinary retention); Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; take at orthostatic hypotension; sedation/central nervous bedtime if taking once daily to minimize sedation; contact your doctor if you have any changes in mood or system depression; serotonin syndrome (rare); thoughts of suicide abrupt discontinuation may cause withdrawal (nausea, headache, malaise) Nausea, headache, dry mouth/xerostomia, insomnia, hyperhidrosis Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect Nausea/vomiting, sexual dysfunction, serotonin syndrome (rare), dose-related QT-prolongation Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect May cause complex sleep behaviors including sleepwalking, sleep-driving, and engaging in other activities while not fully awake; may impair daytime function; additive effects occur with concomitant use of other Headache, drowsiness CNS depressants; may cause drowsiness and a decreased level of consciousness; elderly patients are at higher risk of falls Nausea/vomiting, sexual dysfunction, serotonin syndrome (rare), dose-related QT-prolongation May cause Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), anaphylaxis and angioedema; may impair motor skills or cognition; Dizziness, somnolence, peripheral edema, may cause somnolence, dizziness, and ataxia; ataxia increased risk of suicidal thoughts or behavior; may cause respiratory depression May cause dose-dependent decreases in blood pressure and heart rate; may worsen sinus node dysfunction and atrioventricular (AV) block; may cause Sedation/somnolence, fatigue/lethargy, somnolence and sedation; abrupt discontinuation has hypotension and bradycardia resulted in clinically significant and persistent rebound hypertension Do not stop abruptly without talking to your doctor as you may experience rebound insomnia; avoid taking after a heavy meal as it may delay onset of action; discontinue if complex sleep behaviors (e.g. sleep driving) occur Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect Separate from magnesium or aluminum-containing antacids by at least 2 hours; consider giving the first dose at bedtime to minimize sedation; contact your doctor if you have any changes in mood or thoughts of suicide Do not stop abruptly as you may experience rebound hypertension; take at bedtime if taking once daily to minimize sedation None Increased risk of suicidal thoughts or behavior; may cause dizziness and ataxia; may cause cardiac arrhythmias, including bradycardia, AV block, and ventricular tachyarrhythmia; should be withdrawn Dizziness, blurry vision and diplopia, gradually (over a minimum of 1 week) to minimize the nausea/vomiting, cardiac arrhythmias potential of increased seizure frequency in patients with seizure disorders; may cause Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures None Can cause serious rashes, included the StevensJohnson syndrome, requiring hospitalization and discontinuation of treatment; may cause hemophagocytic lymphohistocytosis (HLH); may cause drug reaction with eosinophilia and systemic symptoms (DRESS); may slow ventricular conduction Dizziness, somnolence, nausea (widen QRS) and induce arrhythmias; may cause blood dyscrasias (neutropenia, leukopenia, anemia, thrombocytopenia, pancytopenia); increase risk of suicidal thoughts or behavior; should not be abruptly discontinued (there is a possibility of increasing seizure frequency) in patients with epilepsy Contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures; contact your doctor if you notice any unexpected rashes, especially with irritated eyes, sore throat, nose, muscle aches, and/or fever; if you stop taking lamotrigine, contact your doctor as you may need to start back at a lower dose and increase slowly Levetiracetam Keppra, Keppra XR ICARE-NeuroPsych Antiseizure drug Synaptic Vesicle Glycoprotein 2A (SV2A) Modulator Oral, Intravenous None Lisdexamfetamine Vyvanse ICARE-NeuroPsych Attention-deficit/hyperactivity disorder (ADHD) treatment Psychostimulant Oral Use with monoamine oxidase inhibitors (MAOIs) Lithium Eskalith, Lithobid ICARE-NeuroPsych Mood stabilizer Miscellaneous Mood Stabilizer Oral Should generally not be given to patients with significant renal or cardiovascular disease, severe debilitation or dehydration, or sodium depletion, and to patients receiving diuretics Lorazepam Ativan ICARE-NeuroPsych Sedative-hypnotic, antiseizure drug Benzodiazepine Oral, Intramuscular, Intravenous May cause behavioral abnormalities and psychotic symptoms; may cause somnolence and fatigue; AEDs increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication; may cause anaphylaxis or angioedema; Somnolence, asthenia, dizziness, may cause serious dermatological reactions, aggression/irritability including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN); should not be abruptly discontinued (there is a possibility of increasing seizure frequency); may cause hematologic abnormalities Contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures CNS stimulants have a high potential for abuse and dependence; may cause sudden death, stroke, and myocardial infarction; may cause an increase in blood pressure and heart rate; may exacerbate symptoms of behavior disturbance and thought disorder in patients with a pre-existing psychotic disorder; may Insomnia, tachycardia and hypertension, cause weight loss and slowing of growth rate in irritability, decreased appetite and weight loss pediatric patients; may cause peripheral vasculopathy, including Raynaud's phenomenon; may cause serotonin syndrome when used in combination with other drugs that affect the serotonergic neurotransmitter systems; Monitor growth regularly (in children); contact your doctor if you have any changes in mood or thoughts of suicide; do not take more than prescribed Lithium toxicity; may be associated with diminution of renal concentrating ability, occasionally presenting as nephrogenic diabetes insipidus, with polyuria and polydipsia; may impair mental and/or physical abilities; may cause fetal harm when administered to a pregnant woman Concomitant use with opioids; risk of abuse, misuse, Acute narrow-angle glaucoma (PO-only); severe respiratory and addiction; may lead to clinically significant insufficiency (except in those patients requiring relief of anxiety physical dependence; increased risk of suicide in and/or diminished recall of events while being mechanically patients with depression; caution in patients with ventilated), obstructive sleep apnea (IM/IV-only) compromised respiratory function (e.g., COPD, sleep apnea syndrome) Lurasidone Latuda ICARE-NeuroPsych Antipsychotic Second-generation Antipsychotic (SGA) Oral Strong CYP3A4 inhibitors; strong CYP3A4 inducers Memantine Namenda ICARE-NeuroPsych Major neurocognitive disorder treatment N-Methyl-D-Aspartate (NMDA) Receptor Antagonist Oral None Methylphenidate Ritalin, Concerta ICARE-NeuroPsych Attention-deficit/hyperactivity disorder (ADHD) treatment Psychostimulant Oral, Transdermal Concomitant treatment with monoamine oxidase inhibitors (MAOIs) Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; antidepressants increase the risk of suicidal thoughts and behavior in pediatric and young adults; increased risk of development of neuroleptic malignant syndrome (NMS) and tardive dyskinesia; may cause metabolic changes that may increase cardiovascular/cerebrovascular risk (hyperglycemia, dyslipidemia, and body weight gain); may cause leukopenia/neutropenia; may cause orthostatic hypotension and syncope; may cause somnolence, postural hypotension, motor and sensory instability; hould be used cautiously in patients with a history of seizures or with conditions that lower the seizure threshold; has the potential to impair judgment, thinking or motor skills Conditions that raise urine pH may decrease the urinary elimination of memantine resulting in increased plasma levels of memantine CNS stimulants have a high potential for abuse and dependence; may cause sudden death, stroke, and myocardial infarction; may cause an increase in blood pressure and heart rate; may exacerbate symptoms of behavior disturbance and thought disorder in patients with a pre-existing psychotic disorder; may cause weight loss and slowing of growth rate in pediatric patients; may cause peripheral vasculopathy, including Raynaud's phenomenon; may cause priapism Fine tremor, polyuria, polydipsia, peripheral edema, nausea/vomiting/diarrhea, drowsiness Monitor for symptoms of too much lithium in the body (e.g. severe nausea, slurred speech, impaired coordination); keep your salt and fluid intake consistent, replacing losses Sedation/drowsiness, impaired coordination, memory impairment, dysarthria, paradoxical reactions Avoid alcohol; do not stop abruptly without talking to your doctor, as you may experience significant withdrawal (including seizures); do not take more than prescribed Somnolence, nausea, extrapyrammidal symptoms (especially restlessness/akathisia), Antipsychotics can increase the risk of high blood sugar and diabetes, cholesterol, and weight gain; contact your doctor if you notice any abnormal movements, as this may be the sign of a potentially irreversible movement disoder called tardive dyskinesia; take with at least 350 Calories for adequate absorption Headache, diarrhea, dizziness, agitation and confusion (rarely) May be opened and sprinkled on applesauce (ER capsules only); administer with provided dosing device (oral solution only) Headache, insomnia, anorexia and weight loss, Monitor growth regularly (in children); contact your doctor if you have any changes in mood or thoughts of increased blood pressure or heart rate, priapism suicide; do not take more than prescribed (rare but serious) Mirtazapine Remeron ICARE-NeuroPsych Antidepressant Alpha-2 adrenergic antagonist, Antidepressant Oral Concomitant treatment with monoamine oxidase inhibitors (MAOIs) Antidepressants increase the risk of suicidal thoughts and behaviors in pediatric and young adult patients; serotonergic antidepressants can precipitate serotonin syndrome, a potentially life-threatening condition. The risk is increased with concomitant use of other serotonergic drugs; may trigger an angleSomnolence, increased appetite and weight closure glaucoma attack; may cause drug reaction gain, orthostatic hypotension and dizziness, dry with eosinophilia and systemic symptoms (DRESS); mouth may cause increased appetite and weight gain; may cause somnolence; in patients with bipolar disorder, treating a depressive episode with an antidepressant may precipitate a mixed/manic episode; may cause hyponatremia Modafinil Provigil ICARE-NeuroPsych Central Nervous System Stimulant Psychostimulant Oral None May cause serious or life-threatening rash, including SJS, Toxic Epidermal Necrolysis (TEN), and Drug Rash with Eosinophilia and Systemic Symptoms (DRESS); may cause angioedema and hypersensitivity; may cause excessive sleepiness; may cause psychiatric symptoms. Caution should be exercised when modafinil is given to patients with a history of psychosis, depression, or mania; Headache, nausea, nervousness/anxiety, increase in gamma glutamyltransferase (GGT) and alkaline phosphatase (AlkPhos) Nortriptyline Pamelor ICARE-NeuroPsych Antidepressant Tricyclic Antidepressant (TCA) Oral Concomitant treatment with monoamine oxidase inhibitors (MAOIs); during the acute recovery period after myocardial infarction Increased risk of suicidal thinking and behavior in patients aged 24 and younger; may precipitate mania in patients with bipolar disorder; may trigger angleclosure attack in glaucoma; caution in history of serious cardiovascular disease; risk of unmasking Brugada syndrome; caution in history of seizures; risk of serotonin syndrome with other serotonergics Anticholinergic side effects (constipation, xerostomia, mydriasis, urinary retention); Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; take at orthostatic hypotension; sedation/central nervous bedtime if taking once daily to minimize sedation; contact your doctor if you have any changes in mood or system depression; serotonin syndrome (rare); thoughts of suicide abrupt discontinuation may cause withdrawal (nausea, headache, malaise) None Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; the possibility of a suicide attempt is inherent in schizophrenia and in bipolar I disorder, and close supervision of high-risk patients should accompany drug therapy; may cause Drug Reaction Somnolence, anticholinergic side effects with Eosinophilia and Systemic Symptoms (DRESS); (constipation, xerostomia, mydriasis, urinary may cause Neuroleptic Malignant Syndrome (NMS); retention), orthostatic hypotension, typical antipsychotic drugs have been associated with extrapyrammidal symptoms metabolic changes including hyperglycemia, dyslipidemia, and weight gain; may cause tardive dykinesia (TD) and hyparprolactinemia; may cause leukopenia/neutropenia, and rarely agranulocytosis; has the potential to impair judgment, thinking, or motor skills Antipsychotics can increase the risk of high blood sugar and diabetes, cholesterol, and weight gain; contact your doctor if you notice any abnormal movements, as this may be the sign of a potentially irreversible movement disoder called tardive dyskinesia; do not administer with a parenteral benzodiazepine (shortacting IM olanzapine only) May cause hyponatremia; may cause anaphylaxis and angioedema; cross hypersensitivity reaction to carbamazepine; may cause serious dermatological reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN); Dizziness, somnolence, abnormal vision antiepileptic drugs (AEDs) increase the risk of suicidal (diplopia, nystagmus), hyponatremia thoughts or behavior in patients taking these drugs for any indication; should be withdrawn gradually because of the risk of increased seizure frequency; may cause Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); Contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures; contact your doctor if you notice any unexpected rashes, especially with irritated eyes, sore throat, nose, muscle aches, and/or fever Increased risk of suicidal thinking and behavior in patients aged 24 and younger; serotonin syndrome; may increase risk of bleeding events; may trigger an Nausea, somnolence, constipation, sexual angle closure glaucoma attack; may cause dysfunction hyponatremia; may precipitate a mixed/manic episode in patients at risk for bipolar disorder; withdrawal Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect Tolerance and psychological and physical dependence may occur with continued use; elderly or debilitated patients may react to barbiturates with Somnolence, respiratory depression, marked excitement, depression, or confusion; in hypotension and bradycardia, serious skin patients with hepatic damage, barbiturates should be rashes (rare) administered with caution and initially in reduced doses Avoid alcohol; do not stop abruptly without talking to your doctor, as you may experience significant withdrawal (including seizures); do not take more than prescribed Contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures; may cause severe birth defects, so use reliable birth control (females of childbearing age) Contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures; administer in the evening if taking once daily to minimize sedation Olanzapine Zyprexa ICARE-NeuroPsych Antipsychotic Second-generation Antipsychotic (SGA) Oral, Intramuscular Oxcarbazepine Trileptal ICARE-NeuroPsych Antiseizure drug Sodium Channel Blocker Oral Paroxetine Paxil, Paxil CR ICARE-NeuroPsych Antidepressant Selective Serotonin Reuptake Inhibitor (SSRI) Oral Phenobarbital Luminal ICARE-NeuroPsych Sedative-hypnotic Barbiturate None Concomitant treatment with monoamine oxidase inhibitors (MAOIs); concomitant use with thioridazine or pimozide Oral, Intramuscular, Intravenous Porphyria; marked impairment of liver or respiratory function Phenytoin Dilantin ICARE-NeuroPsych Antiseizure drug Sodium Channel Blocker Oral, Intravenous History of prior acute hepatotoxicity attributable to phenytoin; coadministration with delavirdine Abrupt withdrawal of phenytoin in epileptic patients may precipitate status epilepticus; increase risk of suicidal thoughts or behavior; may cause severe cutaneous adverse reactions (SCARs), included toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), acute generalized exanthematous pustulosis (AGEP), and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); may Somnolence, nystagmus, dysgeusia (metallic cause bradycardia and cardiac arrest; may cause taste), gingival hyperplasia, dyskinesia angioedema; may cause acute hepatotoxicity; maycause thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia; may cause decreased bone mineral density (osteopenia, osteoporosis, and osteomalacia) and bone fractures; may cause fetal harm when administered to a pregnant woman; may cause hyperglycemia Pregabalin Lyrica ICARE-NeuroPsych Antiseizure drug Alpha2-delta Calcium Channel Blocker Oral None May increase risk of suicidal thoughts or behavior; may cause angioedema and other types of hypersensitivity; may cause respiratory depression; may cause dizziness and somnolence; withdraw Dizziness, somnolence, peripheral edema, gradually to minimize the potential of increased ataxia seizure frequency in patients with seizure disorders; may cause peripheral edema; may cause weight gain; may cause blurred vision Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect Modafinil is not a cure for sleep problems and does not replace sleep; may be habit forming with long-term use, so do not take more than prescribed; may decrease effectiveness of oral contraceptives Quetiapine Seroquel, Seroquel XR ICARE-NeuroPsych Antipsychotic Second-generation Antipsychotic (SGA) Oral Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; increased risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies; increased risk of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) in elderly patients; may cause neurolepric malignant syndrome (NMS); may cause metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain; may cause tardive dyskinesia; may cause orthostatic hypotension; may cause leukopenia/neutropenia; may cause QT prolongation; may cause somnolence and has a potential to has the potential to impair judgment, thinking, or motor skills Somnolence, anticholinergic side effects (constipation, xerostomia, mydriasis, urinary retention), orthostatic hypotension, extrapyrammidal symptoms Antipsychotics can increase the risk of high blood sugar and diabetes, cholesterol, and weight gain; contact your doctor if you notice any abnormal movements, as this may be the sign of a potentially irreversible movement disoder called tardive dyskinesia Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; may cause cerebrovascular adverse events (e.g., stroke, transient ischemic attack) in elderly patients; may cause neuroleptic malignant syndrome (NMS); may cause tardive dyskinesia; may cause hyperglycemia and diabetes mellitus; may cause hyperprolactinemia; may cause orthostatic hypotension; may cause leukopenia, neutropenia and agranulocytosis; may cause somnolence, with a potential potential to impair judgment, thinking, or motor skills; Somnolence, anticholinergic side effects (constipation, xerostomia, mydriasis, urinary retention), orthostatic hypotension, extrapyrammidal symptoms Antipsychotics can increase the risk of high blood sugar and diabetes, cholesterol, and weight gain; contact your doctor if you notice any abnormal movements, as this may be the sign of a potentially irreversible movement disoder called tardive dyskinesia Dizziness, flushing, drowsiness, chest discomfort/pain, nausea Limit use to <10 days per month to avoid medication-overuse headache; this drug does not decrease the number of migraines that you get Nausea/vomiting, diarrhea, sexual dysfunction, serotonin syndrome (rare), insomnia Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect Dizziness, flushing, tingling, chest discomfort/pain, nausea Limit use to <10 days per month to avoid medication-overuse headache; this drug does not decrease the number of migraines that you get Drowsiness, dizziness, hangover effect, paradoxical reactions (e.g. euphoria) Avoid alcohol; do not stop abruptly without talking to your doctor, as you may experience significant withdrawal (including seizures); do not take more than prescribed None Risperidone Risperdal ICARE-NeuroPsych Antipsychotic Second-generation Antipsychotic (SGA) Oral, Intramuscular None Oral Contraindicated in patients with ischemic coronary artery disease, coronary artery vasospasm, history of stroke or transient ischemic attack, peripheral vascular disease, ischemic bowel disease, uncontrolled hypertension, recent use (i.e., within 24 hours) of another 5-HT1 agonist, ergotamine-containing medication, or ergot-type medication, migraine; concomitant treatment with monoamine oxidase inhibitors (MAOIs) Rizatriptan Maxalt ICARE-NeuroPsych Antimigraine drug 5-HT1B/1D Agonist Sertraline Zoloft ICARE-NeuroPsych Antidepressant Selective Serotonin Reuptake Inhibitor (SSRI) Oral Concomitant treatment with monoamine oxidase inhibitors (MAOIs); use with pimozide Sumatriptan Imitrex ICARE-NeuroPsych Antimigraine drug 5-HT1B/1D Agonist Oral, Intranasal, Subcutaneous Contraindicated in patients with ischemic coronary artery disease, coronary artery vasospasm, history of stroke or transient ischemic attack, peripheral vascular disease, ischemic bowel disease, uncontrolled hypertension, recent use (i.e., within 24 hours) of another 5-HT1 agonist, ergotamine-containing medication, or ergot-type medication, migraine; concomitant treatment with monoamine oxidase inhibitors (MAOIs) Temazepam Restoril ICARE-NeuroPsych Sedative-hypnotic Benzodiazepine Oral Pregnancy Topiramate Topamax ICARE-NeuroPsych Antiseizure drug GABAergic, AMPA Blocker, Sodium Channel Blocker, Carbonic Anhydrase Inhibitor Oral Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT1 agonists; may cause tightness, pain, pressure, and heaviness in the precordium, throat, neck and jaw; may cause cerebral hemorrhage, subarachnoid hemorrhage, and stroke; may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and Raynaud's syndrome; may cause hypertension Increased risk of suicidal thinking and behavior in patients aged 24 and younger; serotonin syndrome; may increase the risk of bleeding events; may precipitate a mixed/manic episode in patients with bipolar disorder; may cause discontinuation syndrome after abrupt discontinuation; may trigger an angle closure glaucoma attack; may cause QTc prolongation Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT1 agonists; may cause tightness, pain, pressure, and heaviness in the precordium, throat, neck and jaw; may cause cerebral hemorrhage, subarachnoid hemorrhage, and stroke; may cause non-coronary vasospastic reactions, such as peripheral vascular ischemia, gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and Raynaud's syndrome; may cause hypertension; may cause seizures Use with opioids may result in profound sedation, respiratory depression, coma, and death; risk of abuse, misuse, and addiction, which can lead to overdose or death; may lead to clinically significant physical dependence; may cause angioedema None May cause visual field defects and a syndrome consisting of acute myopia associated with secondary angle closure glaucoma; may cause decreased sweating and hyperthermia; may cause metabolic acidosis; increased risk of suicidal thoughts or Somnolence, word-finding difficulties, behavior; may cause cognitive/neuropsychiatric decreased appetite and weight loss, adverse reactions; can cause fetal harm when nephrolithiasis administered to a pregnant woman; may cause serious skin reactions (Stevens-Johnson Syndrome [SJS] and Toxic Epidermal Necrolysis [TEN]); may cause hyperammonemia with or without encephalopathy; may cause kidney stones Drink plenty of water to help offset the risk of kidney stones; contact your doctor if you have any changes in mood or thoughts of suicide; do not stop abruptly without talking with your doctor, as you may be at higher risk for seizures; Take at bedtime to minimize daytime sedation; call your doctor if you have an erection lasting longer than 4 hours; may be used as needed ("PRN") for sleep disturbance Trazodone Desyrel ICARE-NeuroPsych Antidepressant Serotonin Reuptake Inhibitor, 5-HT2A Antagonist Oral Concomitant treatment with monoamine oxidase inhibitors (MAOIs) Increased risk of suicidal thinking and behavior in patients aged 24 and younger; may precipitate serotonin syndrome, a potentially life-threatening condition; may cause arrhythmias in patients with preexisting cardiac disease; may cause hypotension; may increase the risk of bleeding events; may cause priapism; may precipitate a mixed/manic episode in bipolar disorder patients; may cause discontinuation syndlrome; may cause somnolence or sedation and may impair the mental and/or physical ability required for the performance of potentially hazardous tasks; may trigger an angle closure glaucoma attack; may cause hyponatremia Venlafaxine Effexor, Effexor XR ICARE-NeuroPsych Antidepressant Serotonin-norepinephrine Reuptake Inhibitor (SNRI) Oral Concomitant treatment with monoamine oxidase inhibitors (MAOIs); pimozide Increased risk of suicidal thinking and behavior in patients aged 24 and younger; may precipitate serotonin syndrome; may cause hypertension; may increase the risk of bleeding events; may precipitate a Nausea, headache, dry mouth/xerostomia, mixed/manic episode in patients with bipolar disorder; insomnia, hyperhidrosis may cause discontinuation syndrome after abrupt discontinuation; may trigger an angle closure glaucoma attack; may cause seizures; may cause hyponatremia; may cause sexual dysfunction Vilazodone Viibryd ICARE-NeuroPsych Antidepressant Serotonin Reuptake Inhibitor, 5-HT1A Partial Agonist Oral Concomitant treatment with monoamine oxidase inhibitors (MAOIs) Ziprasidone Geodon ICARE-NeuroPsych Antipsychotic Second-generation Antipsychotic (SGA) Oral, Intramuscular Zolpidem Ambien, Ambien CR ICARE-NeuroPsych Sedative-hypnotic Z-hypnotic Oral, Sublingual Ondansetron Antiemetic Selective 5-HT3 Receptor Antagonist Oral, Intramuscular, Intravenous Increased risk of suicidal thinking and behavior in patients aged 24 and younger; precipitate serotonin syndrome; may cause arrhythmias in patients with preexisting cardiac disease; may cause hypotension; may increase the risk of bleeding events; may precipitate a mixed/manic episode in bipolar disorder patients; may cause discontinuation syndlrome; may trigger an angle closure glaucoma attack; may cause seizures; may cause hyponatremia Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; increased risk of stroke and transient ischemic attacks in elderly patients; may prolong the QTc interval; may cause neuroleptic malignant Contraindicated in patients with a known history of QT syndrome (NMS); may cause tardive dyskinesia; may prolongation (including congenital long QT syndrome), in patients with recent acute myocardial infarction, in patients with cause Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); metabolic changes that may uncompensated heart failure increase cardiovascular/cerebrovascular risk; may cause hypotension; may cause leukopenia, neutropenia and agranulocytosis; may cause hyperprolactinemia; may cause somnolence and impair judgment, thinking, or motor skills May cause abnormal thinking and behavior changes; may cause anaphylactic reactions; has CNSdepressant effects and should only be taken None immediately prior to going to bed; increased sensitivity to sedative/hypnotic drugs in elderly and/or debilitated patients. Precautions: QT prolongation, Serotonin syndrome, use in ileus or gastric distention, may contain benzyl Concomitant apomorphine alcohol and derivatives associated with toxicity in neonates Precautions: upper gastrointestinal adverse reactions, Abnormalities of the esophagus which delay emptying such as severe bone/joint/muscle pain, risk of osteonecrosis stricture or achalasia, inability to stand/sit upright for at least 30 of the jaw, risk of atypical femur fractures, renal minutes, hypocalcemia impairment Precautions: risk of anhidrosis/hyperthermia, risk of anticholinergic effects, do not use in patients with Age <3 years-old tardive dyskinesia, avoid use in patients with glaucoma, GI obstruction or urinary retention Somenolence, hypotension, nausea/vomiting, priapism Do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide; may take at least 4-6 weeks for onset of effect Headache, diarrhea, nausea, sexual dysfunction Take with food; do not stop abruptly without talking to your doctor as you may experience significant withdrawal; contact your doctor if you have any changes in mood or thoughts of suicide Somnolence, QT-prolongation, orthostatic hypotension, extrapyrammidal symptoms Antipsychotics can increase the risk of high blood sugar and diabetes, cholesterol, and weight gain; contact your doctor if you notice any abnormal movements, as this may be the sign of a potentially irreversible movement disoder called tardive dyskinesia; take with at least 500 Calories for adequate absorption Drowsiness, dizziness, headache Do not stop abruptly without talking to your doctor as you may experience rebound insomnia; avoid taking after a heavy meal as it may delay onset of action; discontinue if complex sleep behaviors (e.g. sleep driving) occur Constipation, headache, malaise, prolonged QTC Administrating Ondansetron ODT: Dry hands before handling disintegrating tablet, do not open the blister pack that contains the tablet until you are ready to take it, do not push the oral disintegrating tablet through the foil, place tablet in mouth, allow to melt, swallow, or drink water Abdominal pain, acid regurgitation, constipation, diarrhea, dyspepsia Administer first thing in the morning and ≥30 minutes before food, beverage (except water) or other medications with a full glass of water. Required to stay upright for ≥30 minutes and until after first food of the day. if taking for osteoporosis, consider calcium and vitamin D supplementation. Tachycardia, confusion, blurred vision, confusion May impair heat regulation, avoid activities requiring mental alertness or coordination until drug effects are realized, do not drink alcohol Zofran ICARE-SPECIAL POPS Alendronate Fosamax, Binosto ICARE-SPECIAL POPS Bisphosphonate Bisphosphonate Oral Benztropine Cogentin ICARE-SPECIAL POPS Anti-Parkinson Anticholinergic Oral, Intramuscular, Intravenous Bimatoprost Lumigan, Latisse ICARE-SPECIAL POPS Antiglaucoma Prostoglandin Opthalmic None Precautions: pgimentation and reversible eyelash thickening Conjuncitval hyperemia Wash your hands and remove contact lenses before using (wait 15 minutes before reinserting), instruct patient on proper eye drop administration technique, separate from other eye drops by 5 minutes Brimonidine Alphagan P, Lumify ICARE-SPECIAL POPS Antiglaucoma Alpha 2 Agonist Opthalmic Concurrent MAO inhibitor therapy, use in children <2 y of age (higher risk of systemic adverse events) Precaution: potentiation of vascular insufficiency, risk of CNS depression Allergic conjunctivitis, burning sensation, hypertension, visual disturbance, xerostomia Wash your hands and remove contact lenses before using (wait 15 minutes before reinserting), instruct patient on proper eye drop administration technique, separate from other eye drops by 5 minutes Precautions: somnolence, hyperpyrexia and confusion, compulsive behaviors Dyskinesia, orthostatic hypotension, constipation, nausea, headache None Pruritis of ear Place orally disintegrating tablet on tongue; does not require water or swallowing; may cause body fluid discoloration and have it appear as dark color during therapy Warm solution by holding container in hands for at least 1 minute before use, admin