Structure and Function of Normal Oral Mucosa 2021.pdf

18/01/2021 Structure of Normal Oral Mucosa Selvam Thavaraj 1 2 3 4 Mucosa = Epithelium + Lamina propria 5 6 1 18/01/2021 7 8 Buccal mucosa Labial mucosa Labial mucosa Hard palate Hard palate Soft palate Buccal mucosa Buccal mucosa Ventral tongue Dorsal tongue Soft palate Masticatory mucosa Buccal mu...

18/01/2021 Structure of Normal Oral Mucosa Selvam Thavaraj 1 2 3 4 Mucosa = Epithelium + Lamina propria 5 6 1 18/01/2021 7 8 Buccal mucosa Labial mucosa Labial mucosa Hard palate Hard palate Soft palate Buccal mucosa Buccal mucosa Ventral tongue Dorsal tongue Soft palate Masticatory mucosa Buccal mucosa Ventral tongue Dorsal tongue Floor of mouth Floor of mouth Labial mucosa 9 Labial mucosa 10 Masticatory mucosa Labial mucosa Masticatory mucosa Labial mucosa Lining mucosa Lining mucosa Hard palate Buccal mucosa Soft palate Dorsal tongue Buccal mucosa Buccal mucosa Ventral tongue Soft palate Dorsal tongue Floor of mouth Buccal mucosa Ventral tongue Floor of mouth Labial mucosa 11 Specialised mucosa Hard palate Labial mucosa 12 2 18/01/2021 13 14 15 16 Masticatory mucosa 17 18 3 18/01/2021 Keratinised layer Stratum granulosum Maturation Stratum spinosum M Basal layer G1 G2 Proliferation S 19 20 Basal layer 21 Basal layer 22 Berkovitz, Barry K. B., et al. Oral Anatomy, Histology and Embryology E-Book, Elsevier, 2017 23 24 4 18/01/2021 Basal cell Bullous pemphigoid Ag Lamina lucida Laminin BM-1 Lamina densa Type IV collagen BM-1 Anchoring fibril Type VII collagen 25 26 Stratum spinosum Basal layer 27 28 Berkovitz, Barry K. B., et al. Oral Anatomy, Histology and Embryology E-Book, Elsevier, 2017 29 30 5 18/01/2021 31 32 Cornified layer Stratum granulosum Stratum granulosum Stratum spinosum Stratum spinosum Basal layer Basal layer 33 34 35 36 Candi E, Schmidt R, Melino G. Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40 6 18/01/2021 Loricrin, profilaggrin, involucrin Desmoglein, desmocollin, CK9, CK10 Desmoglein CK5, CK14 37 38 Masticatory mucosa Keratinised layer Lining mucosa Superficial layer Stratum intermedium Lining mucosa Stratum granulosum Stratum spinosum Basal layer 39 Stratum spinosum Basal layer 40 Ten Cate's Oral Histology: Development, Structure, and Function, 9e (2017) 41 42 7 18/01/2021 43 44 Specialised mucosa 45 46 47 48 8 18/01/2021 https://histology.medicine.umich.edu/resources/oral-cavity-pharynx-esophagus-stomach 49 50 51 52 Non-keratinocyte cells in oral epithelium Melanocytes Langerhans cells Merkel cells 53 54 9 18/01/2021 Learning Objectives 55 Define mucosa, lamina propria and submucosa. Define, locate and differentiate between lining, masticatory and specialised mucosa. Relate the structure of lining, masticatory and specialised mucosa to their functions. Describe the mucosa of the dorsum of the tongue including the various papillae. Compare the structure and function between oral and tongue base epithelium. List the non-keratinocyte cells within oral epithelium and state their functions. 56 Recommended Text Integration with other parts of the course BDS 1 BDS 2 Epithelial tissues & their surface specialisations and junctions Prof. I. Mason Oral and nasal cavity Dr B. Webb Cytoskeleton, cell adhesion and motility Prof. I. Mason Functional anatomy of the periodontal tissues Dr A. Hasan Gingiva and peri-implant tissues Dr M. Ide Histology of skin and its appendages Prof. P. Zammit Chapter 12: Oral Mucosa Non-keratinocytes pp270-272 57 Chapter 14: Oral Mucosa Cytokeratins pp265-267 58 59 10