screaming.pdf

Aripiprazole (Abilify®) Key Mechanism of Action Dopamine and serotonin partial agonism Dosing and Formulations Initial: 10-15 mg once daily, max 30 mg Tablet, solution, ODT, tablet with an embedded sensor, IM injections Drug Interactions CYP2D6 and 3A4 substrate – dose adjustments Warnings and Preca...

Aripiprazole (Abilify®) Key Mechanism of Action Dopamine and serotonin partial agonism Dosing and Formulations Initial: 10-15 mg once daily, max 30 mg Tablet, solution, ODT, tablet with an embedded sensor, IM injections Drug Interactions CYP2D6 and 3A4 substrate – dose adjustments Warnings and Precautions Impulsivity Suicidal thoughts in children, adolescents, and young adults ( IV No Benzodiazepine monotherapy Intramuscular antipsychotic + intramuscular benzodiazepine 54  Igalmi™ (Dexmedetomid ine) Approved in April 2022 for agitation associated with schizophrenia or bipolar disorder ~$126/per 1 +lm  Previously, only used in the ICU setting and only available as an IV, now available as a sublingual ?lm as well  Side e6ects include drowsiness, dry mouth, hypotension, dizziness, somnolence, and QTc prolongation 55 TreatmentResistant Schizophre nia Lack of symptom improvement despite two adequate trials of antipsychotics from di erent classes Treatment recommendation: 56 Helpful Tips  Which antipsychotics have long-acting or immediate-acting injections? What is the injection frequency for longacting injections?  What is unique between each agent?  How can I group similarities between certain agents? 57 Therapeutics of Antipsychotics Carolanne Wartman, PharmD, BCPS (she/her) PHCY 506: Integrated Systems - CNS Module February 3, 2023