Quiz 2 Study Guide.pdf

Immunology Quiz 2 Study Guide What type of cells capture microbial antigens and display them for recognition by T lymphocytes? Antigen-presenting cells (APCs). Major histocompatibility complex (MHC) = Human leukocyte antigens (HLAs) Human genome contains two sets of genes called the: class I and cla...

Immunology Quiz 2 Study Guide What type of cells capture microbial antigens and display them for recognition by T lymphocytes? Antigen-presenting cells (APCs). Major histocompatibility complex (MHC) = Human leukocyte antigens (HLAs) Human genome contains two sets of genes called the: class I and class II MHC genes Types of Antigen-presenting cells (APCs). 1. Dendritic cells 2. Macrophages 3. B lymphocytes 4. Follicular dendritic cells 5. But in fact…..Any nucleated cell can function as an APC What lymphoid organs react to cell-free antigen from the lymph and blood, respectively? Lymph Node: lymphoid organs react to cell-free antigen from the lymph. Spleen: lymphoid organs react to cell-free antigen from the Blood What cells phagocytose pathogens and antigens in the epithelia and migrate to lymphoid organs to engage cells in the adaptive immune response? Dendritic cells What is the genetic locus that was the principal determinant of acceptance or rejection of tissue grafts exchanged between individuals? Major histocompatibility complex (MHC) What best describes the gene expression of the MHC genes? Codominant expressed. The alleles inherited from both parents are expressed equally. What type of MHC complex is expressed by all nucleated cells? Class I MHC molecules are expressed on all nucleated cells. Class II MHC molecules are expressed on Professional APCs. There are three Class I genes in humans: HLA-A, HLA-B, HLA-C Proteins are class I and II MHC molecules membrane bound proteins that each contains a “peptide binding cleft” What MHC molecule displays 8 to 9 amino acids bowing out similar to a rainbow? MHC class I molecule What word best describes a property of the major histocompatibility complex (MHC) genes? Polymorphism What MHC molecule is expressed mainly on dendritic cells, macrophages and B lymphocytes? MHC class I molecule MHC 1 presentation of a peptide from a virally infected cell would associate with a CD8+T-cell.