Saint Gabriel College School of Pharmacy IPS 2 (Pharmacology 1) PDF Pretest

Saint Gabriel College School of Pharmacy IPS 2 (PHARMACOLOGY 1 ) PRETEST 1. The purpose of biotransformation reaction is?...

Saint Gabriel College School of Pharmacy IPS 2 (PHARMACOLOGY 1 ) PRETEST 1. The purpose of biotransformation reaction is? a. active transport b. Ion pair transport a. deactivate the drug c. convective transport b. preserve the drug from destruction d. facilitated transport c. Promote the elimination of the inactive drug d. a and c 9. Drugs that are poorly lipid soluble or extensively ionized at the Ph of the blood generally: 2. The effect of the reduced particle size of a drug is? a. Penetrate the CNS very slowly and may a. increase absorption essentially be eliminated from the body before a b. increased disintegration significant concentration in CNS is reached. c. increased hardness b. Achieve adequate CNS concentration only if d. all of the above given IV c. Must be metabolized to a more polar form 3. Which of the following crystal forms give the best before they can gain access to the CNS dissolution rate? d. Can gain access to the CNS if other drugs are a. meta-stable polymorph used to modify the blood Ph. b. amorphous c. stable polymorph 10. If organs and tissues are well perfused: d. a and c a. distribution is lower b. distribution is faster 4. A site in the biophase to which drug molecules can be c. distribution rate is negligible bound is: d. NOTA a. fluid compartment b. unit membrane 11. If drug A is more lipophilic than Drug B then,: c. receptor a. Drug A will be better distributed than Drug B d. all of the above b. Drug B will be better distributed than Drug A c. Both will be distributed better 5. The major plasma protein involved in the distribution d. None of the above of weak acid is: a. albumin 12. A term defined as the combination of a drug b. glycoprotein molecule with a receptor. c. glycine a. antagonism d. gelatin b. intrinsic activity c. affinity 6. An inactive or much less active substance which is d. membrane coefficient transformed to active drug in the body is: a. dosage form 13. In general, the form of the drug that can be absorbed b. drug product faster is: c. aspirin a. Ionized d. prodrug b. Unionized c. bound form 7. The metabolism of drugs generally results in: d. a and c a. less acidic compounds b. more acidic compounds 14.If the particle size decreases: c. more polar compounds a. dissolution rate decreases d. compounds having a higher oil /water b. dissolution rate increases partition coefficient c. surface are decreases d. NOTA 8. A type of transport whereby drug molecules dissolved in aqueous medium at the absorption site move along 15. Typical responses to B-receptor blockade? with the liquid through pore: Prepared by: Rocelyn Mae V. Abboc, RPh  a. Bradycardia c. Arrythmias b. Increased renin secretion d. Glaucoma c. Increased skeletal muscle tremor e. GERD d. Glycogen synthesis 22. Which of the following effects is/are consistent with e. Lipolysis the systemic use of the drug Clonidine? 16. The following are effects of cholinergic agonists I. Initial transient increase in blood pressure EXCEPT. II. “First-dose” phenomenon a. Bradycardia III. Lowering of the blood pressure b. Bronchoconstriction c. Miosis a. I only d. Xerostomia b. I and II e. All of the above c. III only 17.Which of the following are effects of B2 receptor d. I and III stimulation? e. I. II, and III I. Bronchoconstriction 23. Guanfacine and Guanabenz are primarily agonists at II. Tremor what receeptors? III. Tocolysis a. Muscarinic-1 IV.Hyperkalemia b. Nicotinic-N c. Presynaptic alpha-2 a. II, IV d. Postsynaptic alpha-2 b. II, III e. Alpha-1 c. I, III, IV 24. Which of the following drugs primarily stimulates d. II, III,IV beta-1 receptors? e. None of the above a. Dobutamine b. Ritodrine 18. Which of the following drugs acting on biosynthesis c. Yohimbine of neurotransmitters is incorrect? d. Phenoxybenzamine a. Ephedrine- release e. Oxymetazoline b. Vesamicol- storage 25. A new drug is currently being developed whose c. Amitryptiline- release mechanism of action is stimulation of the beta-3 d. Metyrosine- synthesis receptors. In which condition will this drug have most e. Hemicholinium- storage likely usefulness? 19. Adrenergic peripheral responses are mediated by a. Obesity what type of receptors? b. Bronchial asthma I. Alpha receptors c. Hypertension II. Beta receptors d. Shock III. Muscarinic receptors e. Acute renal failure 26. Responsible for fight, flight, fright responses. a. I and II a. Sympathetic b. I,II and III b. Parasympathetic c. II and III c. Enteric d. I and III d. Dopamine e. All of the above e. Muscarinic 20. Dopamine: 27. Release of neurotransmitter is stimulated by? a. cholinergic agonist a. Amphetamine b. adrenergic agonist b. Oxytocin c. anticholinesterase agent d. Guanadrel d. anticholinergic agent e. Guanethidine e. Autacoid 28. First line in the management of cardiogenic shock 21. One of the presented conditions cannot be managed and used for Pharmacologic Stress Testing. by using B blockers: a. Epinephrine a. Hypotension b. Norepinephrine b. Angina pectoris c. Dobutamine Prepared by: Rocelyn Mae V. Abboc, RPh  d. Dopamine b. Posology e. None of the above c. Toxicology 29. Results from the overstimulation of alpha 1 receptors d.Pharmacognosy a. Vasodilation e. Dosology b. Vasoconstriction c. Septic shock 37. In what condition are nonselective alpha blockers d. Tachyarrythmia (e.g phentolamine, phenoxybenzamine) useful? e. Bradycardia a. Essential hypertension 30. Abrupt withdrawal of this agent causes rebound b. Migraine hypertension. c. Benign Prostatic Hyperplasia a. Dopamine d. Pheochromocytoma b. Methoxamine e. None of the above c. Clonidine 38. Which of the following is incorrect? d. Tamsulosin a. Alpha agonist causes miosis e. Ace inhibitors b. Alpha agonist causes vasoconstriction 31. A selective D1 agonist, a vasodilator and used as an c. Beta antagonist decrease formation of aqueous alternative for hypertensive crisis. humor a. Clonidine d. Beta 2 agonist cause bronchodilation b. Sumatriptan e. Beta 3 agonist cause lipolysis c. Fenoldopam d. Dopamine 39. The process with the slowest rate constant in a e. None of the above system of simultaneous kinetic processes: a. lag time 32. Histamine 1 receptor blockers are useful in the b. rate limiting step treatment of: c. bioequivalence a. Allergic rhinitis d. accumulation b. Urticaria e. ceiling effect c. both a and b 40. A phase 1 biotransformation reaction. Except: d. Acid reflux a. methylation e. None of the above b. sulfoxidation 33. The following are effects of Atropine except______. c. deamination a. Dryness of the mouth d. hydrolysis b. Dilation of pupils e. none of the above c. Decrease in heart rate 41. Which of the following is not a selective beta 1 d. Inhibition of sweating blocker? e. None of the above a. betaxolol b. timolol 34. Which of the following antihistamines is LEAST c. atenolol likely to cause sedation? d. metoprolol a. Doxylamine e. Adrenaline b. Astemizole 42. Which of the following antihypertensive is c. Cetirizine contraindicated in pregnancy? d. Tripelennamine a. Nifedipine e. Dantrolene b. Losartan 35.The branch of pharmacology that deals with the study c. Labetalol of the action of drug on functions of the body? d. Hydralazine a. Toxicology e. None of the above b. Pharmacodynamics 43. The following are adverse effects associated with c. Pharmacokinetics nitrates except: d. Pharmacovigilance a. Headache e. None of the above b. Reflex tachycardia 36.A branch of pharmacology that deals with the study c. Tolerance of doses. d. Methemoglobinemia a. Pharmacy e. All of the above Prepared by: Rocelyn Mae V. Abboc, RPh  51. Drugs with “narrow” therapeutic window means that 44. A type of angina that is precipitated by reversible the drug is_____? spasm of coronary vessels and often occurs at rest. a. less potent a. Classic angina b. more potent b. Unstable angina c. less safe c. Variant angina d. more safe d. Crescendo angina e. Any of the above e. None of the above 45. Used in the prevention of seizures during pre- For numbers 52-53: eclampsia. a. Magnesium sulfate b. Minoxidil c. Losartan d. Labetalol e. Nifedipine 46. Which of the following anti-hypertensive agents is the most appropriate for elderly male patients with benign prostatic hyperplasia? a. HCTZ b. Metoprolol c.Prazosin d. Amlodipine 52. Which of the following statements are true? e. Enalapril I. Drug A is more efficacious than Drug C 47. What organ is affected by Torsades de pointes? II. Drug B is the least efficacious a. Liver III. Drug C equally efficacious as Drug B b. Kidney a. I only c. Heart b. II only d. Lungs c. I and II e. Brain d. I, II, and II 48. Type of hypertension accompanied by target end- e. None of the above organ damage? 53. Arrange the drugs in increasing potency (refer to the a. Hypertensive crisis diagram) b. Hypertensive emergency a. A