PMY 211 Pharmaceutics I Past Paper PDF 2017

FACULTY OF PHARMACY, NUTRITION AND DIATETICS PMY 211 PHARMACEUTICS I END OF SEMESTER EXAMINATION JUNE SERIES PAPER 1 WEDNESDAY...

FACULTY OF PHARMACY, NUTRITION AND DIATETICS PMY 211 PHARMACEUTICS I END OF SEMESTER EXAMINATION JUNE SERIES PAPER 1 WEDNESDAY 10 TH MAY 2017 TIME: 14:00 TO 17: 00 DURATION: 3 HOURS INSTRUCTIONS TO CANDIDATES Do not open this Question Paper until you are told to do so Write your computer number in the spaces provided on the Answer Sheet There are FIFTY (50) MULTIPLE CHOICE QUESTIONS in this paper. Read the instructions very carefully before attempting to answer the question. ADDITIONAL MATERIALS 1. Answer sheet 2. Scientific Calculator 1 Directions for Questions 1 – 7. In this section, each question or incomplete statement is followed by five suggested answers. Select the best answer in each case. 1. A manufacturer wishes to produce a batch of compressed tablets each containing 800 mg active ingredient, with a mean table weight of 1.2 g. Which of the following is the weight of active ingredient that will be required for a total batch size of 720 kg? A. 600 kg B. 400 kg C. 250 kg D. 480 kg E. 420 kg 2. Your hospital pharmacy department has been asked to supply a 20 cm2 bioadhesive patch containing 50 mg/cm2 of 5-aminolevulinic hydrochloride (ALA) for use in a clinical trial on a named-patient basis. You know that 30 g aqueous gel containing ALA is required to prepare a patch of this drug loading 100 cm2 in area. Which of the following is the concentration of ALA in an aqueous gel used to prepare the 20 cm2 patch with an ALA loading of 50 mg/cm2? A. 1000 mg ALA in 6 g gel B. 500 mg ALA in 6 g gel. C. 50 mg ALA in 20 g gel D. 50 mg ALA in 30 g gel E. 2000 mg ALA in 6 g gel 3. You have in your pharmacy an unopened 25g tube of Metvix cream (16% w/w methylaminolevulinate). Which of the following is the amount of compatible diluent cream required to dilute this 25 g cream to a level of 4% methylaminolevulinate? A. 25 g B. 50 g C. 75 g D. 100 g E. 125 g 4. An ointment has the following formula: Calamine 5% w/w Zinc oxide 10% w/w\ 2  White Soft Paraffin, BP to 100% w/w Which of the following are the amounts of calamine and zinc oxide required to produce 80 g of this ointment? A. 1.25 g calamine and 2.5 g zinc oxide B. 2.5 g calamine and 5 g zinc oxide C. 5 g calamine and 10 g zinc oxide D. 8 g calamine and 16 g zinc oxide E. 4 g calamine and 8 g zinc oxide 5. A patient has been prescribed 60 g of 0.2% w/w glyceryl trinitrate ointment for an anal fissure. The only strength glyceryl trinitrate ointment that you have available is 0.3% w/w. Which of the following is the amount of the 0.3% w/w glyceryl trinitrate ointment that you would need to prepare the required product? A. 40 g B. 50 g C. 30 g D. 20 g E. 15 g 6. Which of the following is the volume of Molipaxin liquid (trazodone hydrochloride 50 mg/5 mL) required to be added to a suitable diluent to obtain 100 mL trazodone hydrochloride liquid 10 mg/5 mL? A. 60 mL B. 70 mL C. 50 mL D. 20 mL E. 40 mL 7. Which of the following amounts of white soft paraffin is required to make 250 g of the product below? Zinc oxide 12% w/w Salicylic acid 1% w/w Starch 15% w/w White soft paraffin to 100% w/w A. 70 g B. 100 g C. 150 g D. 180 g 3  E. 200 g 8. A vial containing 200 mg hydrocortisone sodium succinate powder for injection is to be reconstituted to produce 4 mL of injection. Which of the following is the amount of Water for Injections, BP that should be added to the powder? The displacement volume of hydrocortisone sodium succinate is 0.05 mL/100 mg. A. 2.0 mL B. 2.5 mL C. 3.5 mL D. 3.9 mL E. 4.0 mL 9. Which of the following is the volume of chlorhexidine gluconate 5% w/v solution that you would need to add to a suitable diluent to obtain 750 mL chlorhexidine gluconate 2% w/v solution? A. 75 mL B. 150 mL C. 250 mL D. 300 mL E. 500 mL 10. The formula for Chloral Elixir, Paediatric, BP is: Chloral hydrate 200 mg Water 0.1 mL Blackcurrant syrup 1.0 mL Syrup to 5.0 mL You are presented with a prescription, for a 1-year-old child, for 150 mL Chloral Elixir, Paediatric, BP. You decide to make it up as an extemporaneous preparation. Which of the following is the amount of chloral hydrate that you would need? A. 0.3 g B. 3.0 g C. 6.0 g D. 0.6 g E. 10.0 g 4 11. You are requested to supply 250 g of a 1 in 4 dilution of Eumovate (0.05% w/w clobetasone butyrate) cream in aqueous cream. Which of the following are the correct amounts of the two creams that you would need? A. 112.5 g Eumovate plus 112.5 g aqueous cream B. 75 g Eumovate plus 175 g aqueous cream C. 50 g Eumovate plus 200 g aqueous cream D. 100 g Eumovate plus 150 g aqueous cream E. 62.5 g Eumovate plus 187.5 g aqueous cream 12. Which of the following is the percentage strength (w/w) of a saturated aqueous solution of sodium bicarbonate if it requires 20 mL water to just dissolve 2 g? A. 4.54% B. 9.09% C. 10% D. 10.9% E. 11.1% 13. Which of the following is the correct number of allopurinol 300 mg tablets required when preparing the following prescription for a gout patient who is currently unable to swallow tablets? Allopurinol 50 mg/mL Cherry syrup ad 150 mL 10 mL in the morning after food A. 20 B. 25 C. 10 D. 15 E. 40 14. Alupent syrup contains 10 mg/5 mL orciprenaline sulphate and Mucodyne oral liquid contains 125 mg/5 mL carbocisteine. Which of the following are the total daily doses of orciprenaline sulphate and carbocisteine received by a patient treated with 10 mL of the mixture below three times daily? Alupent syrup/Mucodyne oral liquid 50/50 mix A. 25 mg orciprenaline sulphate and 250 mg carbocisteine B. 25 mg orciprenaline sulphate and 375 mg carbocisteine 5  C. 30 mg orciprenaline sulphate and 375 mg carbocisteine D. 30 mg orciprenaline sulphate and 250 mg carbocisteine E. 40 mg orciprenaline sulphate and 250 mg carbocisteine 15. A manufacturer wishes to produce a batch of methylene blue gel for photodynamic antimicrobial chemotherapy of wound infections. The gel contains 20% w/w methylene blue. Which of the following is the weight of methylene blue that will be required for a total batch size of 360 kg? A. 36 kg B. 72 kg C. 50 kg D. 20 kg E. 80 kg 16. Which of the following are the correct amounts of diclofenac sodium and misoprostol required to prepare 25 tablets according to the formula for an individual tablet given below? Diclofenac sodium 50 mg Misoprostol 200 micrograms Lactose q.s. (sufficient quantity) A. 1250 mg diclofenac sodium and 50 mg misoprostol B. 1250 mg diclofenac sodium and 0.5 mg misoprostol C. 250 mg diclofenac sodium and 5 mg misoprostol D. 125 mg diclofenac sodium and 0.5 mg misoprostol E. 1250 mg diclofenac sodium and 5 mg misoprostol 17. Which of the following is the amount of erythromycin ethyl succinate in 60 mL of a 500 mg/5 mL oral liquid? A. 3 g B. 12 g C. 6 g D. 60 g 6  E. 30 g 18. Which of the following is the amount of 20% w/w benzocaine ointment required to be added to a suitable diluent ointment to prepare 5 kg of a 2.5% w/w benzocaine ointment? A. 2 kg B. 6.25 g C. 62. 5 g D. 625.0 g E. 2.5 kg 19. Which of the following is the number of furosemide 20 mg tablets required to prepare sufficient 50 mg/5 mL furosemide oral suspension to last 12 days for an infant taking 25 mg furosemide once daily? A. 5 B. 10 C. 15 D. 20 E. 25 20. Your sterile manufacturing unit has been asked to supply eye drops with the following formula: Dorzolamide hydrochloride 2% w/v Timolol maleate 0.5% w/v Which of the following are the correct amounts of the two drugs required to prepare 25 mL? A. 5.000 mg dorzolamide hydrochloride and 0.125 mg timolol maleate B. 500 mg dorzolamide hydrochloride and 12.5 mg timolol maleate C. 125 mg dorzolamide hydrochloride and 500 mg timolol maleate D. 12.5 mg dorzolamide hydrochloride and 500 mg timolol maleate E. 500 mg dorzolamide hydrochloride and 125 mg timolol maleate 21. Which of the following is the concentration of glucose in a solution prepared by mixing 400 mL of 10% w/v glucose, 100 mL of 20% w/v glucose and 200 mL of 5% w/v glucose. A. 5% w/v B. 10% w/v C. 12.5% w/v 7  D. 15% w/v E. 17.5% w/v Directions for Questions 22 – 24. For each numbered question, select the one lettered option that is most closely related to it. Within the group of questions, each lettered option may be used once, more than once or not at all. Questions 22, 23 and 24 concern the following quantities: A. 125 mg Q22 B. 200 mg Q23, Q24 C. 250 mg D. 500 mg E. 750 mg Select, from A to E above, which is appropriate: 22. The amount of amoxicillin in a 5 mL dose if a bottle contains 2.5 g amoxicillin powder and the pharmacist adds 72 mL purified water to prepare 100 mL suspension. 23. The amount of betamethasone valerate in 200 g of a 0.1% w/w betamethasone valerate cream. 24. The amount of porfimer sodium in 20 mL of a 1 in 100 solution. Directions for Questions 25 – 27. For each numbered question, select the one lettered option that is most closely related to it. Within the group of questions, each lettered option may be used once, more than once or not at all. Questions 25 – 27 concern the following quantities: A. 24.5 mL Q25 B. 4.85 mL C. 19.85 mL Q26 D. 15.45 mL E. 3.65 mL Q7 Select, from A to E above, which is appropriate: 25. The volume of Water for Injection, BP to be added to a vial containing 500 mg cyclophosphamide to produce 25 mL. The displacement volume of cyclophosphamide is 0.1 mL/100 mg. 8 26. The volume of Water for Injection, BP to be added to a vial containing 50 mg doxorubicin to produce an injection with a concentration of 2.5 mg/mL. The displacement volume of doxorubicin is 0.03 mL/10 mg. 27. The volume of water to be added to a vial containing 400 mg sodium valproate to produce a solution with a concentration of 100 mg/mL. The displacement volume of sodium valproate is 0.7 mL/800 mg. Directions for Questions 28 –30. For each numbered question, select the one lettered option that is most closely related to it. Within the group of questions, each lettered option may be used once, more than once or not at all. Questions 28 – 30 concern the following quantities: A. 4 mL B. 16 mL Q28 C. 4.5 mL Q29 D. 15mL E. 2ml Q30 Select, from A to E above, which is appropriate: 28. The amount of water required to dissolve 200 mg of a drug that has a solubility of 1 in 80 in water and 1 in 12 in alcohol. 29. The volume of glycerol required to prepare 15 mL of the following ear drop formulation under sterile conditions: Sodium bicarbonate 500 mg Glycerol 3 mL Water to 10 mL 30. The volume of phenoxymethylpenicillin suspension containing 100 mg drug if 5 g phenoxymethylpenicillin powder is made up to a final volume of 100 mL. Directions for Questions 31– 33. For each numbered question, select the one lettered option that is most closely related to it. Within the group of questions, each lettered option may be used once, more than once or not at all. Questions 31 – 33 concern the following quantities: A 1.0g Q33 9  B 10.0 g C 3.0g Q32 D 2.5 g E 1.25g Q31 Select, from A to E above, which is appropriate: 31. The amount of toluidine blue O required to prepare a 25 cm2 mucoadhesive patch for photodynamic therapy of oral candidiasis if the desired drug loading is 50 mg/cm2. 32. The amount of hexylaminolevulinate contained in 75 mL of a 4.0% w/w solution for instillation into the bladder for photodynamic diagnosis of bladder cancer. 33. The amount of ketoconazole in 100 g of a cream prepared according to the following formula: Nizoral cream 50% Aqueous cream 50% Nizoral cream containing 2.0% w/w ketoconazole. Directions for Questions 34 to 60. The questions in this section are followed by three responses. ONE or MORE of the responses is (are) correct. Decide which of the responses is (are) correct. Then choose; A if all the statements are correct, B if the first and second statements are correct, C if the second and third statements are correct, D if only the first statement is correct, and E if only the third statement is correct. SUMMARY FOR DIRECTIONS A B C D E 1, 2, 3 1, 2 Only 2, 3 Only 1 Only 3 Only 34. You receive a prescription to prepare 500 mL of a mixture composed of: Motilium suspension 1 part Kolanticon gel 2 parts Zantac syrup 2 parts Given that Motilium suspension contains 5 mg/5 mL of domperidone, Kolanticon gel contains 2.5 mg/5 mL of dicycloverine hydrochloride and Zantac syrup contains 75 mg/5 mL of ranitidine hydrochloride, which of the following is/are correct?ans1,2 ONLY 1 100 mL of the mixture contains 20 mg domperidone 2 100 mL of the mixture contains 20 mg dicycloverine hydrochloride 3 100 mL of the mixture contains 20 mg ranitidine hydrochloride 35. You are asked to prepare the following ear-drop formulation under aseptic conditions: 10  Hydrogen peroxide solution (6% v/v) 25% Water 75% Which of the following is/are correct? 1. 100 mL of the ear-drop formulation contains 25 mL hydrogen peroxide 2. 40 mL of the ear-drop formulation contains 35 mL water 3. 50 mL of the ear-drop formulation contains 12.5 mL hydrogen peroxide solution 36. The formula for Alkaline Gentian, Mixture, BP is: Concentrated compound gentian infusion 100 mL Sodium bicarbonate 50 g Double-strength chloroform water 500 mL Water to 1000 mL Which of the following is/are correct? E ONLY 3 IS CORRECT 1. The concentration of sodium bicarbonate in Alkaline Gentian, Mixture, BP is 5000 ppm 2. 250 mL Alkaline Gentian, Mixture, BP contains 2.5 mL concentrated compound gentian infusion 3. 10 mL Alkaline Gentian, Mixture, BP contains 5 mL double strength chloroform water 37. The formula for 100 capsules of Paracode is: Paracetamol 50 g Codeine phosphate 800 mg Lactose 20 g Which of the following is/are correct? A.1,2.3 ARE CORRECT 1. 30 capsules contain 15 g paracetamol 2. A patient taking two capsules four times daily ingests 1.6 g lactose/day 3. 15 capsules contain 120 mg codeine phosphate 38. The formula for Paediatric Ferrous Sulphate Mixture is: Ferrous sulphate 60 mg Ascorbic acid 10 mg Orange syrup 0.5 mL Double-strength chloroform water 2.5 mL Water to 5.0 mL 11  Which of the following is/are correct? C.2,3 ONLY 1. The concentration of ascorbic acid in Paediatric Ferrous Sulphate Mixture is 20 mg/mL 2. 250 mL of Paediatric Ferrous Sulphate Mixture contains 25 mL orange syrup 3. 15 mL of Paediatric Ferrous Sulphate Mixture contains 7.5 mL double-strength chloroform water 39. The formula for coal tar and zinc ointment is: Strong coal tar solution 100 g Zinc oxide 300 g Yellow soft paraffin 600 g Which of the following is/are correct?B.1,2 ONLY 1. The concentration of zinc oxide in coal tar and zinc ointment is 30% w/w 2. 250 g coal tar and zinc ointment contains 25 g strong coal tar solution 3. The concentration of yellow soft paraffin in coal tar and zinc ointment is 50% w/w 40. The formula for Magnesium Trisilicate Mixture, BP is: Magnesium trisilicate 50 g Light magnesium carbonate 50 g Sodium bicarbonate 50 g Concentrated peppermint emulsion 25 mL Double-strength chloroform water 500 mL water to 1000 mL Which of the following is/are correct?B 1,2 ONLY 1. The concentration of light magnesium carbonate in Magnesium Trisilicate Mixture, BP is 50 mg/mL 2. 500 mL Magnesium Trisilicate Mixture, BP contains 12.5 mL concentrated peppermint emulsion 3. 30 mL of Paediatric Ferrous Sulphate Mixture contains 150 mg sodium bicarbonate 41. The formula for an extemporaneously prepared ointment is: White soft paraffin 25 g Betnovate ointment 20 g Salicylic acid 5g Given that Betnovate ointment contains 0.1% w/w betamethasone valerate, which of the following is/are correct? E..ONLY 3 12  1. The concentration of salicylic acid in this extemporaneously prepared ointment is 5% w/w 2. The concentration of betamethasone valerate in this extemporaneously prepared ointment is 0.02% w/w 3. 75 g of white soft paraffin would be required to prepare 150 g of this extemporaneously prepared ointment 42. A 65-kg patient is prescribed sodium nitroprusside for hypertensive crisis by intravenous infusion. The registrar has requested that the drug is prescribed initially as 1 microgram/kg per min, and then increased in steps of 500 ng/kg per min every 5 min up to a maximum of 8 micrograms/kg per min. If the infusion is commenced at 10.10 am:C,2,3ONLY 1. At 10.13am 65 mg sodium nitroprusside will have been administered 2. At 10.17am 0.52 mg sodium nitroprusside will have been administered 3. At 10.21am the patient will be receiving the drug at a rate of 0.00013 g/min 43. Which of the following is (are) correct? B.1,2 ONLY 1. A dose rate of 20 micrograms/min is equivalent to 1.2 mg/h 2. A dose rate of 15 mg/h is equivalent to 0.000015 kg/h 3. A dose rate of 10 drops/min is equivalent to 0.006 L/h given that 1 drop = 0.1 mL 44. Calcijex (calcitriol) injection is available as 1 mL ampoules available in two strengths: 1 microgram/mL and 2 micrograms/mL. The injection solution can be given orally. E,3 ONLY 1. A 1-year-old girl, weighing 10 kg, is prescribed calcitriol orally at a dose of 20 ng/kg once daily for vitamin D-dependent rickets. It is appropriate to give this girl 0.4 mL of the 1 microgram/mL injection solution daily 2. An 18-month-old girl, weighing 2 stone, is prescribed calcitriol orally at a dose of 15 ng/kg daily for hypophosphataemic rickets. It is appropriate to give this girl 0.25 mL of the 2 micrograms/mL injection solution daily. (1 stone ≈ 6.35 kg) 3. A 16-year-old boy, weighing 55 kg, is prescribed calcitriol orally at a dose of 0.001 mg daily for persistent hypocalcaemia. It is appropriate for this boy to take 0.5 mL of the 2 micrograms/ mL injection solution daily 45. Epoetin beta has been prescribed for a range of indications for the following patients:A.1,2&3 ARE CORRECT 13  1. Mr B, weighing 75 kg, has been prescribed the drug at a dose of 20 units/kg three times weekly for 4 weeks. Over the 4 weeks Mr B will have taken 18 000 units epoetin beta 2. Catherine, weighing 60 kg, has recently had her dose increased to 80 units/kg three times weekly for 4 weeks. Each week Catherine will take 14 400 units epoetin beta 3. A 2-day-old neonate, weighing 1.25 kg, has been prescribed epoetin beta at a dose of 250 units/kg three times weekly. Each week this newborn will be given 937.5 units 46. Which of the following is (are) correct? E.3,ONLY 1. 2 L of a solution is to be given to a patient over an 8-hour period. If 10 drops equal 0.5 mL the solution should be given at a rate of 100 drops/min 2. 1 L of a solution is to be given to a patient over a 2-hour period. If one drop equals 0.1 mL the solution should be given at a rate of 25 drops/min 3. 5 L of a solution is to be given to a patient over a 10-hour period. If one drop equals 0.2 mL the solution should be given at a rate of 2500 drops/h 47. Which of the following is (are) correct? D,1 ONLY 1. You receive a prescription for hydroxycarbamide 80 mg/kg every third day for the month of February, with the first dose to be taken on 3 February. The patient weighs 50 kg, so you should supply 72 hydroxycarbamide 500 mg capsules 2. At 9.45am a 1 L bag of 0.9% saline infusion is set up for a patient at an administration rate of 1 mL/min. After 8 1/2 hours the doctor requests the flow rate to be increased to 90 mL/h. The bag will be due for replacement at 1am 3. An 11-year-old girl is prescribed Solvazinc effervescent tablets at a dose of one tablet three times a day. After the first week of compliant therapy she will have taken 9.45 g elemental zinc. Each Solvazinc effervescent tablet contains 125 mg zinc sulphate monohydrate (45 mg elemental zinc) 48. Which of the following is/are correct? C.2,3 ONLY 1. 40 mL of a 5% v/v ethanol solution contains 0.2 mL ethanol 2. 1000 mL of a 3% w/v salicylic acid lotion contains 30 g salicylic acid 3. 200 mL of a 0.02%w/v beclometasone solution contains 0.04 g Beclomethasone 14 49. Which of the following is/are correct? B.1,2 ONLY 1. Peptac suspension contains 3.1 mmol sodium/5 mL. A patient taking Peptac suspension 20 mL three times daily receives 37.2 mmol sodium ions from this medication each day 2. A suitable dose of carbamazepine in epilepsy for a child up to 1 year is 100–200 mg daily in divided doses. An appropriate dose of Tegretol liquid (100 mg carbamazepine/5 mL) for a 10-month-old baby with epilepsy is 7.5 mL daily in divided doses 3. A doctor requests 50.00 g of 0.05% w/w salicylic acid cream. The amount of salicylic acid required to prepare this cream is 2.50 mg 50. Which of the following is/are correct?E..3 ONLY 1. 125 g porfimer sodium is needed to produce 200 mL of a stock solution which, when 10mL is diluted to 5 L, produces a 1 in 8000 solution 2. 0.02 mL of a 1 in 10 000 solution will provide a 0.2 mg dose of dexamethasone 3. A patient is prescribed three tablets a day for 56 days; you should supply 168 tablets THE END 15