Pharm 1. General Pharmacology.pdf

7/11/24, 10:03 AM Pharm 1. GP Pharm 1. GP * Indicates required question 1. Email * 1. General Pharmacology 2. Aspirin and phenobarbitone are acidic drugs whereas diazepam...

7/11/24, 10:03 AM Pharm 1. GP Pharm 1. GP * Indicates required question 1. Email * 1. General Pharmacology 2. Aspirin and phenobarbitone are acidic drugs whereas diazepam is a basic * 1 point drug. Mention the true/false statements about these drugs. Mark only one oval. A) Aspirin is present mainly in non-ionized form in stomach, hence can be easily absorbed B) Diazepam is mostly absorbed form intestine C) Phenobarbitone can be absorbed from stomach but most of the absorption occurs in small intestine due to its large surface area D) NO drug is absorbed in large intestine due to its very low surface area Disease decreasing the transit time of drugs like diarrhea will increase the drug absorption in small intestine 3. Low apparent volume of distribution of a drug indicates that: * 1 point Mark only one oval. A) Drug has low half life B) Drug has low bioavailability C) Drug has low efficacy D) Drug is not extensively distributed to tissues https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 1/56 7/11/24, 10:03 AM Pharm 1. GP 4. Major determinant of loading dose of a drug is: * 1 point Mark only one oval. A) Half life B) Clearance C) Volume of distribution D) Bioavailability 5. From which of the following routes, bioavailability of the drug is likely to be * 1 point 100 percent? Mark only one oval. A) Intravenous B) Subcutaneous C) Intramuscular D) Intradermal 6. Hepatic First pass metabolism will be encountered by which of the * 1 point following routes of drug administration? Mark only one oval. A) Oral B) Intravenous C) Sublingual D) Subcutaneous https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 2/56 7/11/24, 10:03 AM Pharm 1. GP 7. Loading dose of a drug depends upon: * 1 point Mark only one oval. A) Volume of distribution B) Clearance C) Half life D) Duration of action 8. High plasma protein binding of a drug result in: * 1 point Mark only one oval. A) Increase in Vd B) Decrease in glomerular filtration C) Increase in tubular secretion D) Decreased drug interactions 9. pKa is the pH at which? * 1 point Mark only one oval. A) There is 50% drug in active form B) There is 50% ionized and 50% non-ionized fraction of the drug C) All the drug is in non-ionized form D) All the drug is in ionized form 10. Drug Transport across the cell membrane is mainly by: * 1 point Mark only one oval. A) Simple diffusion B) Active transport C) Failitated diffusion D) Pinocytosis https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 3/56 7/11/24, 10:03 AM Pharm 1. GP 11. Which of the following is not an example of Phase II drug metabolic * 1 point reaction? Mark only one oval. A) Glucuronidation B) Decyclization C) Methylation D) Acetylation 12. Initial feature of storage of drug in the tissues is suggested by: * 1 point Mark only one oval. A) Small apparent volume of distribution B) Large apparent volume of distribution C) Less excretion in urine D) High excretion in saliva 13. Which of the following is a P glycoproteins inducer? * 1 point Mark only one oval. A) Ketoconazole B) Rifampicin C) Erythromycin D) Itraconazole https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 4/56 7/11/24, 10:03 AM Pharm 1. GP 14. If a drug is absorbed through skin, what is the order of maximum * 1 point percutaneous absorption of the drug from the given routes? Mark only one oval. A) Posterior auricular > Scrotum > Scalp > Dorsum of hand > Plantar area B) Scalp > Scrotum > Posterior auricular > Dorsum of hand > Plantar area C) Plantar area > Dorsum of hand >Scalp > Scrotum > Posterior auricular D) Scrotum > Scalp > Posterior auricular > Dorsum of hand > Plantar area 15. Low Vd means * 1 point Mark only one oval. A) The drug has low half life B) The drug does not accumulate in tissues C) The drug has low bioavailability D) The drug has weak plasma protein binding 16. Nitroglycerine is effective when administered sublingually because it is : * 1 point Mark only one oval. A) Non ionized and lipid soluble B) Ionized and lipid soluble C) Non Ionized and Water insoluble D) Ionized and water insoluble 17. What is the rationale behind xenobiotic metabolism by CYP enzymes? * 1 point Mark only one oval. A) Increase in water solubility B) Increase in lipid solubility C) Conversion to an active metabolite D) Makes it suitable to evaporate through skin surface https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 5/56 7/11/24, 10:03 AM Pharm 1. GP 18. Alkaline diuresis is done for treatment of poisoning due to: * 1 point Mark only one oval. A) Morphine B) Amphetamine C) Phenobarbitone D) Atropine 19. The mitochondrial enzyme involved in the metabolism of clopidorgel and * 1 point proton pump inhibitor is : Mark only one oval. A) CYP 2A B) CYP 2B C) CYP 2C19 D) CYP 2D6 20. Identify the wrong statement: * 1 point Mark only one oval. A) Acidic drugs bind to albumin in plasma B) Basic drugs bind to alpha-1 acid glycoprotein in plasma C) Drugs having higher affinity for a plasma protein can displace the other drug from then same protein D) Sex steroid hormones do not bind to any protein in plasma https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 6/56 7/11/24, 10:03 AM Pharm 1. GP 21. The extent to which ionization of a drug takes place is dependent upon * 1 point pKa of the drug and the pH of the solution in which the drug is dissolved. Which of the following statements is NOT correct? Mark only one oval. A) pKa of a drug is the pH at which the drug is 50% ionized B) Small changes of pH near the pKa of a weak acidic drug will not affect its degree of ionization C) Knowledge of pKa of a drug is useful in predicting its behaviour in various body fluid D) Phenobarbitone with a pKa of 7.2 is largely unionized at acid pH and will be about 40% nonionized in plasma 22. All of the following statement regarding bioavailability of a drug are true * 1 point except: Mark only one oval. A) It is a fraction of administered drug that reaches the systemic circulation in unchanged form B) Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous administration C) Low oral bioavailability always and necessarily means poor absorption D) Bioavailability can be determined from plasma concentration or urinary excretion data 23. Drugs with high plasma protein binding have: * 1 point Mark only one oval. A) Short duration of action B) Less drug interaction C) Lower volumes of distribution D) All of the above https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 7/56 7/11/24, 10:03 AM Pharm 1. GP 24. Which does not induce microsomal enzymes ? * 1 point Mark only one oval. A) Cimetidine B) Griseofulvin C) Rifampicin D) Phenobarbitone 25. Which of the following is a prodrug? * 1 point Mark only one oval. A) Ampicillin B) Captopril C) Levodopa D) Phenytoin 26. Which one of the following drug does not have active metabolite? * 1 point Mark only one oval. A) Diazepam B) Propranolol C) Allopurinol D) Lisinopril 27. Apparent volume of distribution (Vd) of a drug exceeds total body fluid * 1 point volume, if a drug is Mark only one oval. A) Sequestrated in body tissues B) Slowly eliminated from body C) Poorly soluble in plasma D) Highly bound to plasma proteins https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 8/56 7/11/24, 10:03 AM Pharm 1. GP 28. Which of the following drug acts as microsomal enzyme inhibitor? * 1 point Mark only one oval. A) Rifampicin B) Cimetidine C) Phenobarbitone D) Phenytoin 29. Which of the following is an inducer of microsomal enzymes? * 1 point Mark only one oval. A) Phenobarbitone B) Paracetamol C) Digoxin D) Penicillin 30. Removal of acidic drugs from body is done by using: * 1 point Mark only one oval. A) Ammonium chloride B) Sodium bicarbonate C) Hydrochloric acid D) Citric acid 31. Very high first pass metabolism is seen in: * 1 point Mark only one oval. A) Digoxin B) Dicumarol C) Propranolol D) Practalol https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 9/56 7/11/24, 10:03 AM Pharm 1. GP 32. 'Bioavailability' is defined as: * 1 point Mark only one oval. A) The volume of plasma completely clearned of a specime compound per unit time and measured as a test kidney function B) The percentage of drug that is detected in the systemic circulation after its administration C) Both D) None 33. Volume of distribution of drug is given by * 1 point Mark only one oval. A) Vd = Dose administrated IV /Plasma concerntration B) Vd = Maximum tolerated dose / Dose administrated IV C) Vd = Dose administrated IV / Total lipid solubility D) Vd = t 1/2 / Dose administrated IV 34. Redistribution phenomenon is seen in : * 1 point Mark only one oval. A) Halothane B) Ether C) Thiopentone D) All https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 10/56 7/11/24, 10:03 AM Pharm 1. GP 35. Sulphonamide is conjugated with * 1 point Mark only one oval. A) Acetylation B) Methylation C) Hydroxylation D) None 36. Nonsynthetic phase I reaction for drug detoxification is * 1 point Mark only one oval. A) Glucuronidation B) Acetylation C) Methylation D) Oxidation 37. Which of the following statements is correct ? * 1 point Mark only one oval. A) Most drugs are absorbed in ionized form B) Basic drugs are generally bound to plasma albumin C) Microsomal enzymes are located in the mitochondria of hepatic cells D) Blood brain barrier is deficient at the chemoreceptor trigger zone 38. Which of the following is NOT a prodrug? * 1 point Mark only one oval. A) Enalapril B) Imipramine C) Sulphasalazine D) Cyclophosphamide https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 11/56 7/11/24, 10:03 AM Pharm 1. GP 39. Loading dose of a drug is given * 1 point Mark only one oval. A) To achieve steady state concentration in short time B) For drugs with short t^1/2 C) To reduce complications D) All of these 40. Alkalinization of urine is done for * 1 point Mark only one oval. A) Weak acid drugs B) Weak basics drugs C) Strong acidic drugs D) Strong basic drugs 41. Loading dose depends on the following factors except: * 1 point Mark only one oval. A) Drug concentration to be achieved B) Volume of distribution C) Clearance of the drug D) Bioavailability of drug 42. Which of the following is a Phase I metabolic reaction? * 1 point Mark only one oval. A) Hydroxylation B) Conjugation C) Glucuronidation D) Sulfation https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 12/56 7/11/24, 10:03 AM Pharm 1. GP 43. In drug metabolism, hepatic cytochrome P-450 system is responsible for: * 1 point Mark only one oval. A) Phase I reactions (hydrolysis, oxidation, reduction etc.) only B) Phase II reactions (conjugation, synthesis etc.) only C) Both phase I and II reactions D) Converting hydrophilic metabolites to lipophilic metabolites 44. Time for peak plasma concentration ( T max) indicates: * 1 point Mark only one oval. A) The rate of elimination B) The rate of absorption C) The duration of effect D) The intensity of effect 45. One of the potential microsomal enzymes inhibitor drug is: * 1 point Mark only one oval. A) Phenobarbitone B) Griseofulvin C) Sodium valproate D) Phenytoin 46. Alkalinization of urine is required to treat toxicity of all Except * 1 point Mark only one oval. A) Methotrexate B) Amphetamine C) Salicylates D) Barbiturates https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 13/56 7/11/24, 10:03 AM Pharm 1. GP 47. Cytochrome P450 enzyme most commonly involved in drug metabolism * 1 point is: Mark only one oval. A) CYP3A4 B) CYP 1AI C) CYP 2E1 D) CYP 2D6 48. Which of the following drugs binds to albumin? * 1 point Mark only one oval. A) Penicillin B) Lidocaine C) Propranolol D) Verapamil 49. Which of the following is an enzyme inhibitor? * 1 point Mark only one oval. A) Ketoconazole B) Rifampicin C) Tolbutamide D) Phenobarbitone https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 14/56 7/11/24, 10:03 AM Pharm 1. GP 50. All of the following antiepileptics are microsomal enzyme inducers * 1 point except: Mark only one oval. A) Valproate B) Phenobarbitone C) Phenytoin D) Rifampicin 51. Which of the following is an effect of grapefruit juice on drug * 1 point metabolism? Mark only one oval. A) Enzyme inducer B) Enzyme inhibitor C) Inhibits tubular secretion D) Inhibits tubular reabsorption 52. Which of the following can result in oral contraceptive failure? * 1 point Mark only one oval. A) Valproate B) Rifampicin C) NSAIDs D) Ethambutol https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 15/56 7/11/24, 10:03 AM Pharm 1. GP 53. The drug which may inhibit P450 for warfarin is which one of the * 1 point following? Mark only one oval. A) Cimetidine B) Ethanol C) Rifampicin D) Procainamide 54. Forced alkaline diuresis is effective in management of poisoning by * 1 point which of the following agents? Mark only one oval. A) Phenobarbitone B) Lead C) Iron D) Organophosphates 55. Which route of drug administration avoids first pass hepatic metabolism * 1 point and is used with drug preparation that slowly releases drugs for periods as long as seven days? Mark only one oval. A) Topical B) Transdermal C) Sublingual D) Oral https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 16/56 7/11/24, 10:03 AM Pharm 1. GP 56. Hemodialysis is useful in all of the following except: * 1 point Mark only one oval. A) Barbiturate poisoning B) Methanol poisoning C) Salicylate poisoning D) Digoxin poisoning 57. The bioavailability of the drug depends upon: * 1 point Mark only one oval. A) First pass metabolism B) Second pass metabolism C) Volume of distribution D) Excretion 58. Bioavailability is: * 1 point Mark only one oval. A) Amount of drug that reach the systemic circulation B) Drug metabolized in liver before the drug reaches the systemic circulation C) Drug metabolized in liver after the drug reaches the systemic circulation D) Maximum by rectal route 59. About biotransformation untrue is * 1 point Mark only one oval. A) Inactive metabolites are formed B) Active metabolites are formed C) More fat soluble metabolites are formed D) More water soluble metabolites are formed https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 17/56 7/11/24, 10:03 AM Pharm 1. GP 60. Which of the following is not a pro-drug? * 1 point Mark only one oval. A) Levodopa B) Enalapril C) Dipivefrine D) Amoxicillin 61. Which of the following is a pro-drug? * 1 point Mark only one oval. A) Lisinopril B) Enalapril C) Chlorpromazine D) Dopamine 62. False regarding Cytochrome P 450 enzyme is: * 1 point Mark only one oval. A) They are involved in the production of steroids B) They absorb maximum light at 450 nm wavelength C) They are present in endoplasmic reticulum of liver cells D) They are non heme proteins 63. A drug has 40% absorption and hepatic extraction ration of 0.6. What is * 1 point the bioavailability of the drug? Mark only one oval. A) 16% B) 24% C) 20% D) 28% https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 18/56 7/11/24, 10:03 AM Pharm 1. GP 64. Most variable absorption is seen with which route? * 1 point Mark only one oval. A) Oral B) Intramuscular C) Intravenous D) Per rectal 65. Branch of Pharmacology that deals with medicinal drugs obtained from * 1 point plants and other natural resources is known as: Mark only one oval. A) Pharmacognosy B) Pharmacogenetics C) Pharmacogenomics D) Pharmacopoeia 66. Which of the following parameter is used to assess the rate of drug * 1 point absorption? Mark only one oval. A) T max B) C max C) Half life D) Area under the curve https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 19/56 7/11/24, 10:03 AM Pharm 1. GP 67. A patient require ceftriaxone 180 mg. You have a 2 ml syringe with 10 * 1 point divisions per ml. The vial contains 100 mg/5 mL of ceftriaxone. How many divisions in the 2 ml syringe will you fill to give 180 mg ceftriaxone? Mark only one oval. A) 18 B) 1.8 C) 20 D) 2 68. A drug X was administered by continuous IV infusion at the rate of 1.6 * 1 point mg/min. Clearance of drug X is 640 ml/ min. If the half-life of the drug is 1.5 h, what would be the concentration of drug after achieving steady state? Mark only one oval. A) 0.0025 mg/mL B) 0.004 mg/mL C) 3.25 mg/mL D) 1.22 mg/mL 69. A patient was administered 200mg of a drug. 75 mg of the drug is * 1 point eliminated from the body in 90 minutes. If the drug follows first order kinetics, how much drug will remain after 6 hrs? Mark only one oval. A) 30.5 mg B) 12.5 mg C) 25 mg D) 50 mg https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 20/56 7/11/24, 10:03 AM Pharm 1. GP 70. Digoxin has a half-life of 40 hours. It helps to determine * 1 point Mark only one oval. A) Regimen for smooth discontinuation B) Need for loading dose in order to get immediate effect C) Regimen for maintenance dose D) Single dose will work for 40 hours 71. Which of the following parameter signifies the effective drug removal * 1 point from the body? Mark only one oval. A) Clearance B) Bioavailability C) Safety D) Volume of distribution 72. True statement about first order kinetics is: * 1 point Mark only one oval. A) A constant amount of a drug is eliminated in unit time B) The half life increases with an increase in dose C) The rate of elimination is constant D) The rate of elimination is proportional to the plasm concentration 73. Loading dose of a drug primarily depends on: * 1 point Mark only one oval. A) Volume of distribution B) Clearance C) Rate of administration D) Half life https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 21/56 7/11/24, 10:03 AM Pharm 1. GP 74. True statement regarding first order kinetics is: * 1 point Mark only one oval. A) Rate of elimination is independent of plasma concentration B) A constant proportion of plasma concentration is eliminated per unit time C) Half life increases with dose D) Clearance decrease with dose 75. Zero order kinetics is followed by all of the following drugs excepts * 1 point Mark only one oval. A) Phenytoin B) Barbiturates C) Alcohol D) Theophylline 76. At toxic doses, zero order kinetics is seen in: * 1 point Mark only one oval. A)Penicillin B)Phenytoin C)Valproate D)Carbamazepine 77. Inter dose interval depends on: * 1 point Mark only one oval. A) Half life of drug B) Dose of drug C) Age of patient D) Bioavailability of drug https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 22/56 7/11/24, 10:03 AM Pharm 1. GP 78. Time required to reach the steady state after a dosage regimen depends * 1 point on: Mark only one oval. A) Route of administration B) Half life of a drug C) Dosage interval D) Dose of drug 79. Zero order kinetic is shown by all excepts * 1 point Mark only one oval. A) High dose salicylates B) Phenytoin C) Ethanol D) Methotrexate 80. The elimination of alcohol follows: * 1 point Mark only one oval. A)Zero order kinetics B) 1st order kinetics C) 2nd orders kinetics D) 3rd orders kinetics 81. The clearance of drug means: * 1 point Mark only one oval. A) Volume of plasma which is cleared of drug in a unit time B) Amount of drug excreted in urine C) Amount of drug metabolized in unit of time D) All of the above https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 23/56 7/11/24, 10:03 AM Pharm 1. GP 82. Zero order kinetics occur in following drug with high dose: * 1 point Mark only one oval. A) Phenytoin and Theophylline B) Digoxin and propranolol C) Amiloride and prebenecid D) Alcohol and theophylline 83. Elimination after 3 half lives in first order kinetics is: * 1 point Mark only one oval. A) 12.5% B) 75% C) 87.5% D) 94% 84. Drug remaining in the body after 3 half lives is: * 1 point Mark only one oval. A) 12.5% B) 75% C) 87.5% D) 94% 85. Drug acting via tyrosine kinase receptors is: * 1 point Mark only one oval. A) TRH B) TSH C) Insulin D) MSH https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 24/56 7/11/24, 10:03 AM Pharm 1. GP 86. True about non-competitive enzyme inhibition is: * 1 point Mark only one oval. A) Km remains same, Vmax decrease B) Km increase, Vmax remains same C) Km decrease, Vmax increases D) Km increases, Vmax increases 87. G-protein coupled receptor that does not act through opening of * 1 point potassium channels is : Mark only one oval. A) Muscarinic M2 receptor B) Dopamine D2 receptor C) Serotonin 5 HT 1 receptor D) Angiotensin 1 receptor 88. Acetazolamide is given to a patient of angle closure glaucoma. It is a * 1 point non-competitive inhibitor of carbonic anhydrase enzyme. Which of the following should be the effect of this drug? Mark only one oval. A) Decrease in Vmax B) Decrease in Km C) Decrease in both Km and Vmax D) No change in Vmax https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 25/56 7/11/24, 10:03 AM Pharm 1. GP 89. Which of the following is correct regarding the mechanism of action of * 1 point thyroid hormones T4 and T3 at thyroid hormone receptor? Mark only one oval. A) These activate phosphatidylinositol/DAG/calcium cascade B)These act by increasing cyclic AMP C) These activate a tyrosine kinase enzyme D) These activate a nuclear transcription factor 90. Which of the following act through G protein coupled receptors? * 1 point Mark only one oval. A) Muscarinic receptors B) Insulin receptors C) Nicotina receptors D) GABA-A receptors 91. Variation in sensitivity of response to increasing doses of the drug in * 1 point different individuals can be obtained from: Mark only one oval. A) Graded DRC B) Quantal DRC C) Potency D) Efficacy https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 26/56 7/11/24, 10:03 AM Pharm 1. GP 92. All of the following can cause SLE-like syndrome except. * 1 point Mark only one oval. A) Isoniazid B) Penicillin C) Hydralazine D) Sulphonamide 93. Which one of the following statements best describes the mechanism of * 1 point action of insulin on target cells? Mark only one oval. A) Insulin binds to cytoplasmic receptor molecule and is transferred as a hormone receptor complex to the nucleus where it acts to modulate gene expression B) Insulin binds to a receptor molecule on the outer surface of the plasma membrane and the hormone surface of the plasma membrane and the hormone receptor complex activates adenylate cyclase through the Gs protein C) Insulin binds to a transmembrane receptor at the outer surface of the plasma membrane, which activates the tyrosine kinase that is the cytosolic domain of the receptor D) Insulin enters the cell and causes the release of calcium ions from intracellular stores 94. A non-competitive inhibitor of an enzyme * 1 point Mark only one oval. A) Increase Km with no or little change in Vmax B) Decrease Km C) Decrease Vmax D) Increase Vmax https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 27/56 7/11/24, 10:03 AM Pharm 1. GP 95. All known effects of cyclic AMP in eukaryotic cells results from: * 1 point Mark only one oval. A) Activation of the catalytic unit of adenylate cyclase B) Activation of synthetase C) Activation of protein kinase D) Phosphorylation of G protein 96. All of the following drugs cause hemolysis in patients with G-6-PD * 1 point deficiency except: Mark only one oval. A) Primaquine B) Chloroquine C) Quinine D) Pyrimethamine 97. Which one of the following statement best describes the mechanism of * 1 point action of insulin on target cells ? Mark only one oval. A) Insulin binds to cytoplasmic receptor molecule and is transferred as a hormone receptor complex to the nucleus where it act as to modulate gene expression B) Insulin binds to a receptor molecule on the outer surface of the plasma membrane and the hormone receptor complex activates adenylate cyclase through the Gs protein C) Insulin binds to a transmemberane receptor at the outer surface of plasma membrane which activates the tyrosine kinase that is the cytosolic domain of the receptor D) Insulin enters the cell and causes the release of calcium ions from the intracellular stores https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 28/56 7/11/24, 10:03 AM Pharm 1. GP 98. A non competitive inhibitor of an enzyme: * 1 point Mark only one oval. A) Increase in Km with no or little change in Vmax B) Decrease Km C) Decrease Vmax D)Increase Vmax 99. All known effect of cyclic AMP in eukaryotic cells results from : * 1 point Mark only one oval. A) Activation of the catalytic unit of adenylate cyclase B) Activation of synthetase C) Activation of protein kinase D) Phosphorylation of G protein 100. All of the following drugs cause hemolysis in patients with G-6-PD * 1 point deficiency except: Mark only one oval. A) Primaquine B) Chloroquine C) Quinine D) Pyrimethamine 101. All of the following agents act by intracellular receptors except: * 1 point Mark only one oval. A) Thyroid hormones B) Vitamin D C) Insulin D) Steroids https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 29/56 7/11/24, 10:03 AM Pharm 1. GP 102. Regarding efficacy and potency of a drug, all are true except: * 1 point Mark only one oval. A) In the clinical setup, efficacy is more important than the potency B) In the log dose response curve, the height of the curve corresponds with efficacy C) ED50 of the drug corresponds to the efficacy D) Drugs that produce a similar pharmacological effect can have different levels of efficacy 103. True statement regarding inverse against is : * 1 point Mark only one oval. A) Binds to the receptor and causes intended action B)Binds to the receptor and causes opposite action C)Binds to the receptor and causes no action D) Binds to the receptor and causes submaximal action 104. Which of the following property of the drug will enable it to be used in * 1 point low concentration ? Mark only one oval. A) High affinity B) High specificity C) Low specificity D) High stability https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 30/56 7/11/24, 10:03 AM Pharm 1. GP 105. Km of an enzyme is : * 1 point Mark only one oval. A) Dissociation constant B) The normal physiological substrate concentration C) The substrate concentration at half maximal velocity D) Numerically identical for all isoenzymes that catalyze a given reaction 106. Which of the following has cytoplasmic receptor? * 1 point Mark only one oval. A) Epinephrine B) Insulin C)FSH D)Cortisol 107. Which of the following is true for receptor action of a drug? * 1 point Mark only one oval. A) An antagonist has both intrinsic activity and affinity for receptor B) An antagonist has affinity but no intrinsic activity and for receptor C) A partial agonist has no intrinsic activity or affinity for receptor D) Intrinsic activity and affinity are not important for drug action 108. All of the following crane plasma membrane except * 1 point Mark only one oval. A) Epinephrine B)Thyroxine C) Testosterone D) Estrogen https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 31/56 7/11/24, 10:03 AM Pharm 1. GP 109. G-coupled protein receptor is: * 1 point Mark only one oval. A)Metabotropic receptors B)Ionic receptors C)Kinase-linked receptors D)Nuclear receptors 110. Antagonism between acetylcholine and atropine: * 1 point Mark only one oval. A) Competitive antagonism B) Physiological antagonism C) Noncompetitive antagonirm D) None 111. When two different chemicals act on two different receptors and their * 1 point response is apposite to each other on the same cell, this is called as Mark only one oval. A)Physiological antagonism B)Chemical antagonism C)Reversible antagonism D)Competitive antagonism 112. Agonist has * 1 point Mark only one oval. A) Affinity with intrinsic activity is 1 B) Affinity with intrinsic activity is 0 C) Affinity with intrinsic activity is -1 D) None https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 32/56 7/11/24, 10:03 AM Pharm 1. GP 113. All of the following drugs can cause SLE like syndrome except: * 1 point Mark only one oval. A) Isoniazid B) Penicillin C) Hydralazine D) Sulphonamide 114. Two drugs having opposite action on different receptors is which type of * 1 point antagoniam Mark only one oval. A) Physical antagonism B) Competitive antagonism C) Non competitive antagonism D) Physiological antagonism 115. Increase in cAMP is caused by: * 1 point Mark only one oval. A) Somatostatin B) Beta receptor C) Alpha receptor D) Acetylcholine 116. Drug which does not cause hemolysis in G6PD deficiency is: * 1 point Mark only one oval. A) Primaquine B) Dapsone C) Corticosteroids D) Methylene Blue https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 33/56 7/11/24, 10:03 AM Pharm 1. GP 117. Which of the following is an example of physiological antagonism? * 1 point Mark only one oval. A) Heparin-Protamine B) Prostacycline Thromboxane C) Adrenaline Phenoxybenzamine D) Physostigmine-Acetylcholine 118. All the following drugs act on ionic channels except: * 1 point Mark only one oval. A) Nicotine B) Insulin C) Glibenclamide D) Diazepam 119. Efficacy of a drug refers to: * 1 point Mark only one oval. A) Affinity of drug to bind to receptors B) Affinity of drug that binds to receptors and activates it C) Dose that requires to produce response D) Maximum response a drug can produce 120. SLE like reaction is caused by: * 1 point Mark only one oval. A) Hydralazine B) Rifampicin C) Paracetamol D) Furosemide https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 34/56 7/11/24, 10:03 AM Pharm 1. GP 121. When a drug binds to the receptor and causes action opposite to that of * 1 point agonist this is called as: Mark only one oval. A) Complete Agonist B) Partial Agonist C) Inverse agonist D) Neutral antagonist 122. The study of how variation in the human genome affect the response to * 1 point medications is known as. Mark only one oval. A) Pharmacogenomics B) Pharmacokinetics C) Pharmacotherapeutics D) Pharmacovigilance 123. Which ONE of the following is TRUE about a competitive antagonism? * 1 point Mark only one oval. A) Antagonism cannot be completely reversed by in creased dose of the agonist B) An agonist cannot displace an antagonists from the re- ceptor C) Agonists and antagonists bind to the same receptor D) Dose-response curve of an agonists shifts to the left in the presence of an antagonist https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 35/56 7/11/24, 10:03 AM Pharm 1. GP 124. A drug that compete for active binding site is called: * 1 point Mark only one oval. A) Competitive inhibitor B) Non-competitive inhibitor C) Covalent inhibitor D) Any of these 125. Partial agonist possess * 1 point Mark only one oval. A) Max intrinsic activity and low affinity B) High intrinsic activity and no affinity C) Low intrinsic activity and high affinity D) Low intrinsic activity and low affinity 126. Pharmacodynamics Includes: * 1 point Mark only one oval. A) Drug elimination B) Drug excretion C) Drag absorption D) Mechanism of action 127. Calcitriol acts on: * 1 point Mark only one oval. A) G-protein coupled receptors B) Cytosolic receptors C) Intranuclear receptors D) Enzymatic receptors https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 36/56 7/11/24, 10:03 AM Pharm 1. GP 128. After giving in enzyme inhibitor, if V decrease to 60% and Km is same * 1 point as before Which type of inhibition in this? Mark only one oval. A) Competitive equilibrium type B) Non -competitive C) Competitive non-equilibrium type D) Un-competitive 129. U shaped dose response curve is seen in: * 1 point Mark only one oval. A) Vitamins B) Anti cancer drugs C) Steroids D) Chelators 130. Therapeutic index is measure of : * 1 point Mark only one oval. A) Safety B) Efficacy C) Potency D) Selectivity https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 37/56 7/11/24, 10:03 AM Pharm 1. GP 131. Therapeutic monitoring of plasma level of drugs is done when using all * 1 point of the following drugs except: Mark only one oval. A) Warfarin B) Gentamicin C) Cyclosporine D) Phenytoin 132. Therapeutic Drug Monitoring (TDM) involves measurement of plasma * 1 point concentrations of drugs to find whether the drug levels are within the therapeutic range or not. For TDM to be clinically useful the following criteria should be fulfilled Mark only one oval. A) There should be good relationship between plasma concentration and drug dosage B) The relationship between plasma drug concentration and therapeutic response and / or toxicity should be poor C) When pharmacodynamic tolerance is suspected D) When the clinical response cannot be easily monitored 133. Which of the following drug needs serum level monitoring? * 1 point Mark only one oval. A) Lorazepam B) Lithium C) Amitryptylline D) Haloperidol https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 38/56 7/11/24, 10:03 AM Pharm 1. GP 134. Which one of the following drugs has narrow therapeutic range? * 1 point Mark only one oval. A) Propranolol B) Phenytoin C) Piroxicam D) Prazosin 135. Therapeutic index is an assessment of * 1 point Mark only one oval. A) Potency of a drug B) Onset of action C) Duration of action D) Margin of safety 136. Therapeutic index is * 1 point Mark only one oval. A) ED50/LD50 B) LD50/ED50 C) ED50 - LD50 D) ED50 X LD50 137. ED50 is used for determine * 1 point Mark only one oval. A) Potency B) Efficacy C) Safety D) Toxicity https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 39/56 7/11/24, 10:03 AM Pharm 1. GP 138. Major aim of phase1 clinical trials is to know the * 1 point Mark only one oval. A) Maximum tolerable dose B) Efficacy C) Safety D) Pharmacokinetics 139. Which of the following is an example of placebo? * 1 point Mark only one oval. A) Herbal medication with no known effect B) Physiotherapy C) Sham surgery D) Cognitive behavioral therapy 140. Which place of clinical trials is done after the drug enters the market? * 1 point Mark only one oval. A) Phase I B) Phase II C) Phase III D) Phase IV 141. Phase 1 clinical trials are mainly done are assessing : * 1 point Mark only one oval. A) Safety B) Efficacy C) Pharmacodynamics D) Dosing https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 40/56 7/11/24, 10:03 AM Pharm 1. GP 142. Design of the study aimed to assess the maximum tolerable dose of a * 1 point new drug is best described as Mark only one oval. A) Case control study B) Phase II Randomized control trial (RCT) C) Phase I trail D) Phase III Randomized control trial (RCT) 143. Comparison of efficacy of a new drug B with an existing drug A is done * 1 point in which phase of clinical trials? Mark only one oval. A) Phase I B) Phase II C) Phase III D) Phase IV 144. True about orphan drug is * 1 point Mark only one oval. A) Developed for orphans B) Drugs used very rarely C) Drug used for rare diseases D) Rare drug for common diseases https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 41/56 7/11/24, 10:03 AM Pharm 1. GP 145. True statement about phases 2 clinical trails is * 1 point Mark only one oval. A) Large number of healthy volunteers are studied B) Used to determine maximum tolerated dose C) Used to determine efficacy D) Used to determine toxicity 146. Good clinical practice(GCP) is not required in * 1 point Mark only one oval. A) Preclinical phase B) Phase I trial C) Phase II studies D) Phase IV studies 147. In which of the following phases of clinical trials, healthy normal human * 1 point volunteers participate Mark only one oval. A) Phase I B) Phase II C) Phase III D) Phase IV https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 42/56 7/11/24, 10:03 AM Pharm 1. GP 148. There are some undesirable but unavoidable pharmaco dynamic effects * 1 point of a drug , which are known as Mark only one oval. A)Toxic effects B) Idiosyncrasy C) Side effects D) Intolerance 149. The aim of post marketing studies is * 1 point Mark only one oval. A) Efficacy of the drug B) Dosage of the drug C) Deals with alteration of the drugs includes absorption distribution, binding / storage D) To know rare adverse effects of the drugs 150. In which phase of clinical trials, post - marketing surveillance of a drug * 1 point is carried out? Mark only one oval. A) Phase I B) Phase II C) Phase III D) Phase IV https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 43/56 7/11/24, 10:03 AM Pharm 1. GP 151. Phase 4 clinical trial also called as * 1 point Mark only one oval. A) Human pharmacology and safety B) Post marketing surveillance C) Therapeutic exploration and dose ranging D) Therapeutic confirmation 152. Phase 4 clinical trial collect information specially about * 1 point Mark only one oval. A) Drug efficacy B) Drug potency C) Drug toxicity D) Pharmacokinetics of the drug 153. Phase 4 clinical trial is carried out * 1 point Mark only one oval. A) Before the marketing approval of a drug B) After a drug is marketed C) For drugs used in rare diseases D) For drugs used in pediatric patients 154. Which of the following is a schedule X - drug? * 1 point Mark only one oval. A) Thalidomide B) Colistin C) Ketamine D) Halothane https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 44/56 7/11/24, 10:03 AM Pharm 1. GP 155. Which of the following drug must be sold by retail only production of a * 1 point prescription by a registered medical practitioner? Mark only one oval. A) Schedule H B) Schedule G C) Schedule X D) Schedule M 156. Store in a cool place is written on a drug label. It means drug should be * 1 point stored at a temperature of Mark only one oval. A) -2 degree Celsius B) 0 degree Celsius C) 2-8 degree Celsius D) 8-15 degree Celsius 157. Manufacturer of a drug company labels the drug contains 500mg * 1 point paracetamol. On govt analysis it was found to contain only 200mg of drug. Which type of drug it is known as? Mark only one oval. A) Fake drug B) Spurious drug C) Adulterant drug D) Misbranded drug https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 45/56 7/11/24, 10:03 AM Pharm 1. GP 158. Which of the following statements about fixed dose combinations of * 1 point drugs is true? Mark only one oval. A) Adverse effect of one drug may be neutralized by the other B) In hepatic dysfunction, metabolism of both drugs is altered C) Dose of one drug can be altered as per requirement D) Adverse effect can be described to a single drug 159. Which of the following statements about clinical trials is * 1 point Mark only one oval. A) Phase 1 is done to determine efficacy and dose in patients B) Healthy volunteers are recruited for the first time in phase 2 C) Randomized controlled trial in patients is done in phase 3 D) Phase 4 is a phramacokinetics study in animals 160. Which of the following instruction should be given to a lactating mother * 1 point regarding drug usage? Mark only one oval. A) No advice is required as most of the drugs are secreted negligibly in the milk B) Take drugs with longer half life C) Tell her to feed the baby just before next dose D) Do not feed the baby if you are consuming any drug https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 46/56 7/11/24, 10:03 AM Pharm 1. GP 161. Which of the following is not necessary to be mentioned on drug * 1 point advertisement literature? Mark only one oval. A) Expiry date of the drug B) References of the information C) Rare but life threatening adverse effects D) Common but insignificant adverse effects 162. The meaning of store in a cool place written over a strip of medicine is * 1 point that it should be kept between temperature of Mark only one oval. A) 2 to 8°C B) 8 to 15°C C) Temperature below freezing point of water D) 0°C 163. Absorption of which of the following drugs is increased when given with * 1 point a fatty meal? Mark only one oval. A) Amphotericin B B) Griseofulvin C) Ampicillin D) Aspirin https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 47/56 7/11/24, 10:03 AM Pharm 1. GP 164. For which of the following drugs a warning is written to be a sold by * 1 point retail on the prescription of a registered medical practitioner only Mark only one oval. A) Schedule H B) Schedule X C) Schedule Y D) Schedule J 165. Type A(augmented) adverse drug reactions are characterized by all * 1 point except Mark only one oval. A) Qualitatively abnormal responses to the drug B) Predictable from the drug's known pharmacological or toxicological effects C) Generally dose dependent D) Usually common 166. In pregnancy, all of the following drugs are contraindicated except * 1 point Mark only one oval. A) ACE inhibitors B) Angiotensin receptor blockers C) Propylthiouracil D) Thalidomide https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 48/56 7/11/24, 10:03 AM Pharm 1. GP 167. Which of the following is excreted in saliva * 1 point Mark only one oval. A) Tetracyclines B) Ampicillin C) Lithium D) Chloramphenicol 168. The pharmacokinetics change occurring in geriatric patients is decline * 1 point in Mark only one oval. A) Gastric absorption B) Liver metabolism C) Renal clearance D) Hypersensitivity 169. Drugs used for rare disease are known as * 1 point Mark only one oval. A) Orphan drugs B) Rare drugs C) Over the counter drugs D) Emergency drugs 170. Type B adverse drug reaction is * 1 point Mark only one oval. A) Augmented effect of the drug B) Allergic effect of the drug C) Effect seen on chronic use of the drug D) Delayed effect of the drug https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 49/56 7/11/24, 10:03 AM Pharm 1. GP 171. Which of the following drug is contraindicated in pregnancy? * 1 point Mark only one oval. A) Enalapril B) Amlodipine C) B - blockers D) Propylthiouracil 172. Most essential medicines should be formulated as * 1 point Mark only one oval. A) No compound B) Single compound C) Multiple compounds D) Fixed dose combinations 173. Which is not an alkaloid * 1 point Mark only one oval. A) Morphine B) Neostigmine C) Emetine D) Atropine 174. As per "Drugs and cosmetic act" prescription drugs are included in : * 1 point Mark only one oval. A) Schedule C B) Schedule H C) Schedule P D) Schedule X https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 50/56 7/11/24, 10:03 AM Pharm 1. GP 175. All the following drugs are teratogenic except * 1 point Mark only one oval. A) Alcohol B) Phenytoin C) Warfarin D) Metoclopramide 176. Phocomelia is best described as * 1 point Mark only one oval. A) Defect in development of long bones B) Defect in development of fat bones C) Defect in intramembranous ossification D) Defect in cartilage replacement by bones 177. Which of the following is the most accurate method for calculating drug * 1 point dosage in children Mark only one oval. A) Weight of the child B) Weight of the child and adult dose C) Age of the child D) Body surface area 178. In which type of poisonings is gastric lavage contraindicated? * 1 point Mark only one oval. A) Organophosphorus poisoning B) Sedative drug poisoning C) Corrosive acid poisoning D) Barium carbonate poisoning https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 51/56 7/11/24, 10:03 AM Pharm 1. GP 179. All of the following are examples of time dependent late adverse drug * 1 point reactions except Mark only one oval. A) Glucocorticoid induced osteoporosis B) Nitrate induced headache C) Chloroquine induced retinopathy D) Amiodarone induced tissue phospholipid deposition 180. which of the following drugs can be given safety in pregnancy? * 1 point Mark only one oval. A)Propylthiouracil B) Sodium valproate C)Warfarin D) Tetracycline 181. Essential medicines are those medicines: * 1 point Mark only one oval. A) That are needed to treat emergency conditions B) That are needed to treat serious disease C) That satisfy the priority health care needs of the population D) That are introduced recently into the market 182. Counterfeit drug is: * 1 point Mark only one oval. A) Fake medicine B) Contains the wrong ingredient C) They have active ingredient in wrong dose D) All of the above https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 52/56 7/11/24, 10:03 AM Pharm 1. GP 183. Which of the following statements about clinical trails is true? * 1 point Mark only one oval. A) Phase 1 is done to determine efficacy and dose in patients B) Healthy volunteers are recruited for the first time in Phase 2 C) Randomized controlled trial in patients is done in Phase 3 D) Phase 4 is a Pharmacokinetics study in animals 184. Variation in sensitivity of response to increasing doses of the drug in * 1 point different individuals can be obtained from: Mark only one oval. A) Graded DRC B) Quantal DRC C) Potency D) Efficacy 185. In competitive inhibition, true is: * 1 point Mark only one oval. A) Vmax increases, km unchanged B) Km unchanged C) Both Km and V max increase D) Km increase, V max unchanged 186. Effect on Vmax and Km in non competitive inhibition is : * 1 point Mark only one oval. A) Vmax increase, Km remains same B) Vmax decrease, Km remains same C) Vmax remains same, Km decreases D) V max increase, Km decreases https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 53/56 7/11/24, 10:03 AM Pharm 1. GP 187. Which of the following drug is contraindicated in acute intermittent * 1 point porphyria? Mark only one oval. A) Lithium B) Ampicillin C) Propofol D) Barbiturates 188. Drug efficacy is defined as: * 1 point Mark only one oval. A) Ability of drug to produce maximum effect by acting on target B) Therapeutic maximum response with dose change C) Minimum amount of drug needed to produce a certain response D) Amount of drug which reaches in circulation unchanged 189. Which of the following statement is true about first order kinetics ? * 1 point Mark only one oval. A) Alcohol is eliminated from body by 1 st order kinetic B) constant concentration of drug eliminated in unit time C) constant fraction of drug eliminated in unit time D)Half-life is dependent on plasma concerntration 190. Which of the following drug does not act by cAMP pathway? * 1 point Mark only one oval. A) Estrogen B) Somatostatin C) Glucagan D) ACTH https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 54/56 7/11/24, 10:03 AM Pharm 1. GP 191. Safety and efficacy of a drug are best established in which phase of * 1 point clinical trial? Mark only one oval. A) Phase I B) Phase II C) Phase III D) Phase IV 192. Phase IV clinical trial is * 1 point Mark only one oval. A) Post marketing trial B) Most important for microdosing of drug C) Not helpful in measuring side effects D) Minimum year of this trail is 10 years 193. Which of the following adverse effect of a drug is explored in the * 1 point treatment of another disease? Mark only one oval. A) Propranolol in migraine B) Nifedipine in migraine C) Metoclopramide in lactation failure D) Minoxidil in alopecia areata This content is neither created nor endorsed by Google. Forms https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 55/56 7/11/24, 10:03 AM Pharm 1. GP https://docs.google.com/forms/d/1k35TuO46ouAcOoGsTRZcZNggYEnIBkC2UiFCrb6_Dmk/edit 56/56