Mycology II: Systemic & Opportunistic Mycoses Lecture Notes PDF

MICROBIOLOGY | TRANS 4B LE Mycology II: Systemic & Opportunistic...

MICROBIOLOGY | TRANS 4B LE Mycology II: Systemic & Opportunistic 02 Mycoses, Antifungal Therapy DR. CHARLES KEVIN RIVERA | Lecture Date (10/04/2024) | Version 1 OUTLINE A. COCCIDIOMYCOSIS I. Risk Factors IV. Antifungal Chemotherapy Also called, “Valley Fever,” “San Joaquin Valley Fever,” II. Systemic Mycoses A. Introduction or “Desert Rheumatism” A. Coccidiomycosis B. Classification of Coccidioides posadasii or Coccidioides immitis B. Histoplasmosis Antifungals → Cause similar manifestations C. Blastomycosis C. Amphotericin B → Phenotypically indistinguishable D. Paracoccidioidomycosis D. Flucytosine → Endemic in Southwestern United States, Central III. Opportunistic Mycosis E. Azoles 💬 America, and South America A. Candidiasis F. Echinocandins G.Griseofulvin Travel history is very important, especially for patients B. Cryptococcosis C. Aspergillosis H. Terbinafine with pneumonia D. Mucormycosis I. Topical Antifungals ▪ C. immitis: California E. Pneumocystis Pneumonia V. Review Questions ▪ C. posadasii: Arizona, Texas, South America F. Penicilliosis VI. References → Infection rate is highest during the dry months of VII. Appendix summer and autumn when dust is most prevalent Must Lecturer Book Previous Youtube → Usually self limited; dissemination is rare but ❗️ Know 💬 📖 📋 Trans 🔺 Video ❗ always serious and fatal Not communicable from person to person Table 1. Coccidioidomycosis SUMMARY OF ABBREVIATIONS ETIOLOGY C. immitis or C. posadasii GMS Grocott Methenamine Silver Primary: Lungs KOH Potassium Hydroxide AREA OF Others: Meninges, skin, & SDA Sabouraud Dextrose Agar INVOLVEMENT subcutaneous tissue, bones & joints LEARNING OBJECTIVES Culture: white to tan cottony colony At the end of this module, you must be able to: Hyphae: chains of arthroconidia (can MORPHOLOGY ✔ Enumerate etiologic agents of systemic mycoses. become airborne) ✔ Explain the pathogenesis of systemic mycoses Dimorphic ✔ Correlate the clinical manifestations of systemic mycoses 60% Asymptomatic CLINICAL to the laboratory data to identify the etiologic agent 40% Self-limited MANIFESTATIONS ✔ Enumerate the appropriate therapeutic measures for the