MBBS Year 1 - Prof GE Mann L2 Digestion and absorption of nutrients.pdf

Prof GE Mann, Waterloo Campus (Email: [email protected]) MBBS Year 1 Gastrointestinal Lectures L1: Overview of the digestive system L2: Digestion and absorption of nutrients L3: Salivary, gastric and pancreatic secretions L4: Bile and biliary system L5: Motility of the gut Physiology, 5th...

Prof GE Mann, Waterloo Campus (Email: [email protected]) MBBS Year 1 Gastrointestinal Lectures L1: Overview of the digestive system L2: Digestion and absorption of nutrients L3: Salivary, gastric and pancreatic secretions L4: Bile and biliary system L5: Motility of the gut Physiology, 5th Edition, eds. RM Berne, MN Levy, BM Koeppen, BA Stanton (2004) (see Chapters 31-33) [see also recent Editions] Medical Physiology, eds. WF Boron & EL Boulpaep (2003) Color Atlas of Physiology, 4th Edition, eds. A. Despopoulos & S. Silbernagl, (1991) 1 MBBS Year 1 Gastrointestional Lectures L2: Digestion and absorption of nutrients Learning Objectives Describe the digestion of protein, carbohydrates and fat from mouth to colon Describe mechanisms involved in intestinal absorption of carbohydrates, proteins, fats: uptake sugars, amino acids, di- and tri-peptides and fats Describe role of pancreas and liver in the digestion of fat Describe clinical consequences associated with malabsorption of nutrients 2 3 Arterial supply and venous drainage in intestinal epithelium 4 5 Arterial supply, venous and lymphatic drainage in intestinal epithelium 6 Histological organisation of intestinal villous and crypt 7 Digestion of carbohydrates and absorption across intestinal villi 8 9 Digestion and absorption of peptides and amino acids 10 Absorption of peptides and amino acids across intestinal villi 11 Intestinal absorption of oligopeptides 12 13 14 15 Overview of intestinal absorption of dietary vitamin A and carotenoids Chylomicrons (retinyl esters/carotenoids) 16 17 Absorption of Ca2+ across intestinal epithelium 18 GI tract important role in excretion, fluid and electrolyte balance 19  Summary of intestinal nutrient absorption None Proteases Amylase Intracellular Hydrolysis Lipase 20