Glycolysis Lecture Notes PDF

Glycolysis 1  Glycolysis It is a ten steps metabolic pathway occurs in cytosol to convert glucose into two molecules of pyruvate and two molecules each of NADH and ATP. All carbohydrates to be catabolized must enter the glycolytic pathway. - Glycolysis is central...

Glycolysis 1  Glycolysis It is a ten steps metabolic pathway occurs in cytosol to convert glucose into two molecules of pyruvate and two molecules each of NADH and ATP. All carbohydrates to be catabolized must enter the glycolytic pathway. - Glycolysis is central in generating both energy and metabolic intermediaries. 2  glucose Glycolysis ATP Hexokinase ADP glucose-6-phosphate Phosphoglucose Isomerase fructose-6-phosphate ATP Phosphofructokinase ADP fructose-1,6-bisphosphate Aldolase glyceraldehyde-3-phosphate + dihydroxyacetone-phosphate Triosephosphate Isomerase 3 Glycolysis continued  glyceraldehyde-3-phosphate NAD+ + Pi Glyceraldehyde-3-phosphate NADH + H+ Dehydrogenase 1,3-bisphosphoglycerate Glycolysis ADP continued. Phosphoglycerate Kinase ATP Recall that 3-phosphoglycerate there are 2 Phosphoglycerate Mutase GAP per 2-phosphoglycerate glucose. H2O Enolase phosphoenolpyruvate ADP Pyruvate Kinase ATP 4 pyruvate  Glycolysis: Specific tissue functions RBC’s – Rely exclusively for energy Skeletal muscle – Source of energy during exercise, particularly high intensity exercise Adipose tissue – Source of glycerol-P for TG synthesis – Source of acetyl-CoA for FA synthesis Liver – Source of acetyl-CoA for FA synthesis – Source of glycerol-P for TG synthesis 5