General Structure of the Digestive Tract PDF

Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) GENERAL STRUCTURE OF THE DIGESTIVE TRACT All regions of the GI tract have...

Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) GENERAL STRUCTURE OF THE DIGESTIVE TRACT All regions of the GI tract have certain structural features in common. The GI tract is a hollow tube with a lumen of variable diameter and a wall made up of four main layers:  The mucosa consists of an epithelial lining; an underlying lamina propria of loose connective tissue rich in blood vessels, lymphatics, lymphocytes, smooth muscle cells, and often containing small glands; and a thin layer of smooth muscle called the muscularis mucosa  The submucosa contains denser connective tissue with larger blood and lymph vessels and the submucosal (Meissner) plexus of autonomic nerves. It may also contain glands and significant lymphoid tissue.  The thick muscularis (or muscularis externa) is composed of smooth muscle cells organized as two or more sublayers. In the internal sublayer (closer to the lumen), the fiber orientation is generally circular; in the external sublayer it is longitudinal. The connective tissue between the muscle sublayers contains blood and lymph vessels, as well as the myenteric (Auerbach) nerve plexus.  The serosa is a thin layer of loose connective tissue, rich in blood vessels, lymphatics, and adipose tissue, with a simple squamous covering epithelium or mesothelium. In places where the digestive tract is not suspended in a cavity but bound directly to adjacent structures, such as in the esophagus the serosa is replaced by a thick adventitia, a connective tissue layer that merges with the surrounding tissues and lacks mesothelium 1  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) TONGUE: The tongue is a mobile mass of striated muscle and mucous membrane that functions is taste, chewing ,swallowing , and speech , the tongue is divided into anterior two thirds and posterior one third , the demarcation between these regions is( V ) shaped groove at the back of the tongue called sulcus terminals. Tongue is covered by stratified squamous epithelium its roughened surface is caused numerous minute projections, the papillae that varying shape and number , by far the most numerous are the small slender , conical , pointed filiform papillae , whose cover the entire dorsal surface , the larger but less numerous mushroom shaped fungiform papillae are scattered among the filiform papillae because the upper flattened domes are less keratinized , the very large circular dome 2  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) shaped circumvallate papillae they resemble the fungiform papillae except that they are much larger than.A fourth type , the foliate papillae although present in young children are rare in adult human , they are found in posterior lateral edges of the dorsum of the tongue , the function of the filiform papillae is to provide a roughened to the tongue and have nerve endings for touch , the fungiform papillae have a few taste buds whereas circumvallate papillae many have 200 or more taste buds. 3 Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) 4  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) TASTE BUDS The sensation of taste is detected by the oval taste buds that resemble flower buds , at the apex of the bud is a small taste pore that connect the anterior of the bud with the oral cavity There are 3 cells types in the taste buds: 1. Sustenacular (supporting) cells : Are elongated with a darker cytoplasm and slender dark nucleus. 1. Light taste or gustatory cells : A lighter cytoplasm and more oval lighter nucleus. 2. The basal cells : Are located at the periphery of the taste bud , near the basement membrane. They are long spindle shaped cells with their pointed distal ends covered by long microvilli that cluster in the fluid – filled space beneath the pore PHARYNX The pharynx is a flattened fibro muscular tube extending from the base of the skull to the lower level of larynx , it is a common chamber for the passage of food liquid and air , it has 3 region the upper part nasopharynx communicate with nasal cavity and the middle part is the oropharynx or throat it is common passageway for both respiratory and digestive system , covered by stratified squamous epithelium , the lower region is laryngo pharrynx covered by non- keratinized stratified squamous epithelium. 5  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) ESOPHAGOUS The first segment in the alimentary canal is the esophagus in the human adult it is a muscular tube that transport the food and liquid from the pharynx to the stomach , it is covered by non keratinized stratified squamous epithelium in general it have the same layers as the rest of the digestive tract it have four layers: MUCOSA The mucosa has atypical structure of the GIT tract the epithelium is non keratinized stratified squamous epithelium that ends in the stomach junction where it becomes simple columnar the lamina propria has a large population of lymphocytes and lymphoid nodules among the fine small branched tubular mucous gland called esophageal cardiac gland because it resemble the cardiac gland in the stomach are found in two area upper esophagus and near the cardiac region of the stomach these glands are a variable in size and may be absent , muscularis mucosa is well developed composed of longitudinal muscle. 6  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) SUBMUCOSA The sub mucosa is an extensive rather loose collagenous and elastic connective tissue zone because it great resiliency it acts as a shock absorber for the large often rough boluses of food and pass through the esophagus during passage these masses compress the mucosa causing it to bulged into the ample pliable sub mucosa thus greatly enlarging the diameter of the narrow lumen of the esophagus. Compound tubuloacinar glands are distributed in the submucosa these are the esophageal gland proper that secret the mucous secretion to facilitate the movement of the food in the esophagus. MUSCULARIS EXTERNA Consist of inner circular and outer longitudinal muscle since the upper third of the esophagus is involved skeletal muscle but in the middle has mix skeletal and smooth but in the lower found only smooth muscle fiber. ADVETITIA The outer most layer is a loose connective tissue 7  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) TYPES OF GLANDS IN THE ESOPAGUS : In the wall of the esophagus there are two types of mucus glands which differ in their locations: 1. Esophagal glands proper Lie in the sub mucosa these glands are scattered along the length of the esophagus but are more concentrated in the upper half , they are small compound tubule alveolar glands, The mucus that produced by the esophageal gland proper it is acidic 2. Esophageal cardiac glands Are named for their similarity to the cardiac glands of the stomach and are found in the lamina propria of the mucosa they are present in the terminal part of the esophagus , Esophageal cardiac glands produced neutral mucus. STOMACH The stomach is the expanded part of the digestive tube it received the food from the esophagus , mixing and partial digestion of the food in the stomach by the its gastric secretions produce pulpy fluid mix called chyme, the chyme then passes in to the small intestine for further digestion and absorption.The stomach divided in to three region : 1. cardiac region (cardia) : The part which are near the esophageal orifice that have the cardiac glands. 2. pyloric region(pylorus) : The part proximal to the pyloric sphincter which contain the pyloric glands. 3. fundic region (fundus): The largest part of the stomach which is situated between the cardia and the pylorus and contain the fundic or gastric glands. 8  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) MUCOSA the mucous membrane (mucosa)of the empty stomach is thrown in to deep irregular longitudinal folds called rugae the surface of the epithelium is simple columnar which invaginates in to lamina propria to form gastric pits , into these pits empty the million of gastric glands largely branched tubular types the thickness of mucosa due to the presence of these gastric glands. The gastric glands are of the three types located in different region in the stomach : 1. cardiac glands located in the narrow ring shaped region when the stomach joins with the esophagus 2. the gastric or fundic glands shaped through out the body and fundus of the stomach 3. the pyloric glands confined to the pyloric region where the stomach joins the small intestine 9  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) The cells lining the gastric glands are: 1. mucose secreting surface epithelium cells (simple columnar) 2. chief zymogenic cells that produce the digestive enzymes pepsin and lipase 3. partial (oxyntic) cells that produce hydrochloride acid 4. mucous neck cells limited to the initial (neck) regions 5. enteroendocrine cells located in the base of the gastric glands they secret the secretin ,gastrin. SUBMUCOSA Composed of blood vessels and nerves (meissners sub mucosal plexus) with loosely arranged collagenous and elastic fibers. MUSCULARIS EXTERNA Has 3 layers of smooth muscle inner oblique , middle circular ,outer longitudinal layer Auerbaches myenteric nerve plexus lies between circular and longitudinal muscle layers 10  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) SEROSA Covering by loose connective tissue surrounded by mesothelium REGIONAL DIFFRENCES IN STOMACH 1. CARDIAC REGION In the small cardiac region the glands are the least numerous because the cardia of the stomach is limited to collar wide around the esophageal orifice , they have rather wide , open, deep pits ,that continue into short , coiled glands lined with mucous type cells the glands occupy the lamina propria and the base rest on muscularis mucosa. 2. FUNDUC OR BODY REGION in the body and the fundus the glands called fundic glands are the most numerous because these regions occupy about three fourths of stomach, fundic glands are narrow , shallow pits, long tubules , the pits are lined with surface mucous – type cells the small irregular neck mucous cells , mucous neck cells produce intermediate product between serous and mucous secretions , the body of elongated fundic gland is lined with partial and chief cells , the chief cells are most numerous they are also called zymogenic cells , they are concentrated in the in the lower part of the fundic glands , the basal part of the cells is basophilic 11  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) Fundic Stomach with a short pit Surface mucus secreting epithelium 3. PYLORIC REGION It is continuous with the duodenum the pyloric glands resemble with cardiac glands but has deeper pits and more branching and coiling of the tubular glands they contain parietal cells and gastrin secreting cells among the mucous like cells that line the pyloric glands. SMALL INTESTINE Small intestine extends from the stomach to the large intestine a distance about 6-8 m has 4 layers resemble the pattern of the GI tract it divided to 3 regions (duodenum , jejunum , and ileum )small intestine has 3 principle functions : 1. complete the digestion of the food by action of the enzyme. 2. absorbed the finished product of digestion into the blood and lymph vessels. 3. synthesized and release hormone. MUCOSA Plicae circularis the mucosal surface of the small intestine undergoes several specializations to increase the surface area the first of these modifications the permanent spiral or circular mucosal folds that extends through out the length of the organ called plicae circularis they greatly increase the mucosal area they reach maximum development in the duodenum and upper jejunum and gradually disappear in the ileum. 12  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) Villi are long finger like or leaf like projections of the mucosa that extends in to the gut lumen , they are cover by simple columnar epithelium resting on surface membrane , intestinal glands (crypts lieberkuhn) other mucosal modifications that increase the surface area , these are straight , un branched , tubular glands ,located in the base of the villi and the muscularis mucosa. Microvilli is the striated border of the lining epithelial cells composed of parallel rows of microvilli of even height , they extend from the cell border like brush bristles, hence the term brush border is a synonym for striated border each microvillus covered by cell plasma membrane , in the center of the microvillus are many longitudinal fine microfilaments some of these microfilaments are actin filaments , Lamina propria the loose reticular connective tissue of the lamina propria forms the core of each villus and fill the potential space between the intestinal glands collections of small lymphocytes form lymph nodules with or without the germinal centers the nodules increase in size and number until in the ileum they form large aggregations called payers patches. 13  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) MUSCULARIS MUCOSA It is thin has 2 layers of smooth muscle inner circular and outer longitudinal layer these layers separate the lamina propria from the submucosa , penetrated with meissners plexus. SUBMUCOSA Large zone compose of areolar connective tissue surrounding larger blood and lymph vessels and nerve plexuses (meissners plexus) and also contain peyers patches in lamina propria contain no glands except in the duodenum. MUSCULARIS EXTERNA Large , has 2 layers inner circular and outer longitudinal of smooth muscle between this 2 layers are frequent parasympathetic (Auerbach plexus),these muscle also facilitate the mixing of food with the digestive enzymes SEROSA Single layer of mesothelium cells resting on thin layer of loose connective tissue ,blood and lymph and nerve traverse the serosa REGIONAL DIFFRENCES IN SMALL INTESTINE DUODENUM It is extends from the pyloric end of the stomach to its junction with the jejunum it is has burners gland in the sub mucosa , leaf shape villi , adventitia and termination of bile and pancreatic ducts. Bruner's glands are mucous compound tubular largely in the sub mucosa but occasionally in lamina propria, their mucin secreting cells are low columnar type , the secretion is strongly alkaline which neutralizes the acidic chyme of the stomach and thus protect the duodenal mucosa from auto digestion , Bruner's glands contain urogastrone , a peptide hormone that inhibits the HCL production in the stomach also called human epidermal growth factor(HEGF). 14  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) The rather short broad leaf shaped villi are most numerous in the duodenum. JEJUNUM Has no really distinctive features , although the finger like villi are the tallest , if the histological section of small intestine dose not contain submucosal glands Bruner's glands or aggregates of lymph nodules in the lamina propria (payers patches) the organ is probably Jejunum. ILEUM The ileum has only one diagnostic feature: the presence of many aggregates of lymph nodules in the lamina propria( payers patches) the lymph nodules are usually pear shaped with tier rounded dome shaped apices directed toward the lumen covered by single layer of epithelium there is evidence that these cells are transport antigens from the lumen to the lymphoid follicles these cells have been designated as follicle associated epithelium (FAE). 15  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) LARGE INTESTINE These parts lie between the ileum and the anus belong to the large intestine in sequences they are cecum ,appendix, colon(ascending+transvers +descending) And the anal canal COLON MUCOSA The mucosa of the colon free from the villi the surface epithelium consist of three type of the cells 1. simple columnar absorptive cells have a thin striated border 2. goblet cells intercalate between the absorptive cells increase in number in the more distal segments of the colon 3. undifferentiated epithelial cells in the bases of the intestine gland(stem cells) 16  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) The lamina propria is similar to that in the small intestine except the solitary lymph nodules are larger and more numerous because of their size they often bulge in the submucosa ,the muscularis has the typical 2 layers of smooth muscles SUBMUCOSA Contain no glands , it has no essential differences MUSCULARIS EXTERNA The inner layer circular and the outer longitudinal muscular is external have the taeniae coli are three separate longitudinal ribbons of smooth muscle on the outside of the ascending, transverse, descending and sigmoid colons. They are visible and can be seen just below the serosa. SEROSA Because the ascending and descending colon are pressed against the body wall by the peritoneum the serosa is incomplete present only on their anterior surface these region attached with the body by adventitia the other regions transverse and pelvic colon have serosa. 17  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) CECUM The beginning of the large intestine is the cecum large sac it is similar to transverse colon including serosa APPENDIX It is small worm shaped tube projection from the end of the cecum it has lymphatic nodules in the lamina propria they may also occupy the submucosa and reduce the lumen appendix to the narrow ,stellate slit. 18  Al – Zahrawi University College Dr. Wael R. Alfatlawi Dep. Dentistry General Histology Second Stage Lec. (10) RECTUM Some structural changes gradually occur in the colon in making the transition to rectal structure : Teniae coli flatten out to form uniform , longitudinal sheets of muscle , the mucosa is thicker , lymphoid nodules are less ANAL CANAL Presents longitudinal folds, anal valves , the epithelium changes from the simple columnar of the rectum , to simple cuboidal at the anal valves , to stratified squamous at the anus. The submucosa is rich in vascular supply , while the muscularis externa forms the internal anal sphincter muscle , an adventitia connects the anus to the surrounding structures. 19