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New Mansoura University

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pharmacology heart failure cardiology medical education

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This document presents a 30-question multiple-choice quiz on the treatment of heart failure, focusing on pharmacology and the potential effects of various drugs. The questions cover topics like cardiac glycosides, their mechanisms of action, and potential adverse effects.

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Okay, here is a 30-MCQ quiz based on the provided lecture: Part One: Simple MCQs (10) 1. Which of the following is NOT a main line of treatment for heart failure? a) Vasodilators b) Diuretics c) Beta-blockers d) Positive inotropic drugs 2. Which of the following is NOT a non-pharmacological therap...

Okay, here is a 30-MCQ quiz based on the provided lecture: Part One: Simple MCQs (10) 1. Which of the following is NOT a main line of treatment for heart failure? a) Vasodilators b) Diuretics c) Beta-blockers d) Positive inotropic drugs 2. Which of the following is NOT a non-pharmacological therapy for heart failure? a) Reducing salt intake b) Weight reduction c) Taking sympathomimetics d) Lifestyle modification 3. Which of the following is NOT a type of positive inotropic drug? a) Cardiac glycosides b) B1-adrenoceptor agonists c) PDE enzyme inhibitors d) Beta-blockers 4. Which of the following is NOT a cardiac glycoside? a) Digoxin b) Digitoxin c) Dobutamine d) Ouabain 5. What is the mechanism of action of cardiac glycosides? a) Inhibition of cardiac Na+/K+ ATPase b) Stimulation of cardiac Na+/K+ ATPase c) Inhibition of cardiac Ca2+ ATPase d) Stimulation of cardiac Ca2+ ATPase 6. Which of the following is NOT an effect of cardiac glycosides due to their positive inotropic action? a) Increased cardiac contractility b) Increased cardiac output c) Reduced size of the failing dilated heart d) Increased venous pressure 7. What is the main therapeutic use of cardiac glycosides in atrial fibrillation? a) To increase the ventricular rate b) To decrease the ventricular rate c) To convert atrial fibrillation to normal rhythm d) To prevent stroke 8. Which of the following is NOT a therapeutic use of cardiac glycosides? a) Atrial fibrillation b) Atrial flutter c) Paroxysmal supraventricular tachycardia d) Hypertension 9. Which of the following is NOT an adverse effect of cardiac glycosides? a) Nausea and vomiting b) Visual disturbances c) Cardiac arrhythmias d) Hyperkalemia 10. Which of the following is NOT a B1-adrenoceptor agonist? a) Dopamine b) Dobutamine c) Amrinone d) Digoxin Part Two: Complex MCQs (20) 1. A patient with heart failure is prescribed digoxin. Which of the following electrolyte imbalances would increase the risk of digoxin toxicity? a) Hyperkalemia b) Hypokalemia c) Hypercalcemia d) Hypocalcemia 2. A patient with atrial fibrillation is prescribed digoxin. What is the primary mechanism by which digoxin exerts its beneficial effect in this condition? a) Increasing myocardial contractility b) Decreasing conduction through the AV node c) Converting atrial fibrillation to normal sinus rhythm d) Reducing the risk of stroke 3. Which of the following statements BEST describes the effect of cardiac glycosides on cardiac output? a) Cardiac glycosides decrease cardiac output by decreasing heart rate. b) Cardiac glycosides increase cardiac output by increasing heart rate. c) Cardiac glycosides increase cardiac output by increasing stroke volume. d) Cardiac glycosides decrease cardiac output by decreasing stroke volume. 4. A patient with heart failure is started on amrinone therapy. Which of the following adverse effects is MOST important to monitor for in this patient? a) Thrombocytopenia b) Hyperkalemia c) Visual disturbances d) Gastrointestinal upset 5. Which of the following is NOT a mechanism of action of amrinone? a) Inhibition of phosphodiesterase III b) Increase in cAMP c) Positive inotropic effect d) Inhibition of Na+/K+ ATPase 6. Which of the following is a common adverse effect of both cardiac glycosides and amrinone? a) Visual disturbances b) Cardiac arrhythmias c) Thrombocytopenia d) Gynecomastia 7. Which of the following is a contraindication to the use of cardiac glycosides? a) Atrial fibrillation b) Atrial flutter c) Wolff-Parkinson-White (WPW) syndrome d) Heart failure 8. Which of the following is NOT a mechanism by which digitalis can cause arrhythmias? a) Increased vagal activity b) Inhibition of the SA node c) Inhibition of the AV node d) Increased sympathetic activity 9. Which of the following BEST describes the role of dobutamine in the treatment of heart failure? a) Long-term management of chronic heart failure b) Short-term management of acute heart failure c) Prevention of cardiac remodeling d) Treatment of supraventricular arrhythmias 10. Which of the following is NOT a reason why dobutamine is NOT suitable for long-term management of chronic heart failure? a) Tolerance b) Lack of oral efficacy c) Arrhythmogenic effects d) Negative inotropic effects 11. Which of the following BEST describes the effect of cardiac glycosides on heart size in heart failure? a) Cardiac glycosides increase heart size. b) Cardiac glycosides decrease heart size. c) Cardiac glycosides have no effect on heart size. d) The effect of cardiac glycosides on heart size depends on the underlying cause of heart failure. 12. Which of the following is NOT a mechanism by which cardiac glycosides increase intracellular calcium? a) Inhibition of Na+/K+ ATPase b) Decrease in activity of Na+/Ca2+ exchange c) Increase in intracellular Na+ d) Stimulation of calcium release from the sarcoplasmic reticulum 13. Which of the following BEST describes the effect of cardiac glycosides on venous pressure in heart failure? a) Cardiac glycosides increase venous pressure. b) Cardiac glycosides decrease venous pressure. c) Cardiac glycosides have no effect on venous pressure. d) The effect of cardiac glycosides on venous pressure depends on the severity of heart failure. 14. Which of the following is NOT a potential adverse effect of cardiac glycosides on the gastrointestinal system? a) Nausea b) Vomiting c) Diarrhea d) Constipation 15. Which of the following types of heart failure are cardiac glycosides MOST effective in treating? a) Heart failure with reduced ejection fraction (HFrEF) b) Heart failure with preserved ejection fraction (HFpEF) c) Both HFrEF and HFpEF d) Neither HFrEF nor HFpEF 16. Which of the following is NOT a potential visual disturbance associated with cardiac glycoside toxicity? a) Yellow vision b) Red vision c) Green vision d) Blurred vision 17. Which of the following is NOT a potential cardiac effect of cardiac glycoside toxicity? a) Sinus bradycardia b) AV block c) Ventricular tachycardia d) Atrial fibrillation 18. Which of the following is NOT a potential non-cardiac adverse effect of cardiac glycosides? a) Skin rashes b) Gynecomastia c) Hypokalemia d) Hyperkalemia 19. Which of the following is NOT a potential drug interaction with cardiac glycosides? a) Diuretics b) Beta-blockers c) Calcium channel blockers d) Angiotensin-converting enzyme (ACE) inhibitors 20. Which of the following is NOT a factor that can influence the risk of cardiac glycoside toxicity? a) Age b) Renal function c) Electrolyte imbalances d) Blood glucose levels Answer Guide Part One 1. c 2. c 3. d 4. c 5. a 6. d 7. b 8. d 9. d 10. c Part Two 1. b 2. b 3. c 4. a 5. d 6. b 7. c 8. d 9. b 10. d 11. b 12. d 13. b 14. d 15. a 16. d 17. d 18. d 19. d 20. d Done

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