Hypersensitivity Types Comparison - Individual Activity Sheet.pdf

HLSC 4650 Hypersensitivity Types Comparison Individual Activity Sheet ACID pneumonic Type I A Allergy, Atopic, anaphylaxsis TYpe II C Cytotoxic cytolytic Type III I Immune complex mediated Type IV D Delayed ...

HLSC 4650 Hypersensitivity Types Comparison Individual Activity Sheet ACID pneumonic Type I A Allergy, Atopic, anaphylaxsis TYpe II C Cytotoxic cytolytic Type III I Immune complex mediated Type IV D Delayed  Hypersensitivity Types Comparison Table Characteristics HR I HR II HR III HR IV Other names IgE- mediated, Cytotoxic or Cytolytic Immune complex Cell mediated or immediate or antibody dependent mediated delayed hypersensitivity cytotoxicity or hypersentitvitiy hypersensitivity reaction reaction, allergic immediate reaction, anaphylaxis, hypersensitivity or atopic reaction hypersensitivity. Type of immunity Humoral Humoral Humoral Cellular (Humoral or Cellular) Mechanism of Upon first exposure ABO and/or Rh Soluble antibody and T helper cells Action igE attaches to mast mismatch causes antigen complex activated by APCs cells that activation of depositing on vessel leading to cell degranulates and complement system walls/tissues- mediated tissue release histamine leading to hemolysis activating complement damage upon second and system leading to subsequent exposure tissue damage Key Players mast cells, Complement protein, Complement protein T cells (T helper, T eosinophils and ABO and Rh Macrophages killer cells (cytotoxic), basophils antigen/antibodies Neutrophils macrophages Antibodies involved IGE IGE, IGM IGE, IGM NO ANTIBODIES Response time 15-30 MINS 15-30MINS 3-10- HOURS 12 FIRST, 48-72 HOURS  Examples ANAPHYLAXSIS Conditions caused by Rheumatoid arthritis Poison Ivy Allergic rhinitis (hay ABO/Rh (RA) fever) incompatibility Tuberculosis Allergic asthma SLE (systemic lupus Allergic conjunctivitis HRT (hemolytic erythematosus) contact dermatitis Allergic reactions to transfusion reaction) food, drug, etc. Glomerulonephritis Mantoux test (TB Atopic dermatitis HDN (hemolytic TEST) disease of newborns Serum sickness Terminal protein- c5-c9 MAC ATTACK Adaptive immunity- slow, specific has memory B cells produce antibodies Hapten is a protein carrier (NOT A LIPID CARRIER) to elict immune response. Hapten is posion ivy. Its an antigen but its too small to elicit a immune response T cell activation is a 2 STEP PROCESS→ 1. specific to MHC 2 and second is post stimulatory. An APC can directly activate cytotoxic cells- bc it has both MHC I AND II. Active- getting it from outside. Vaccination Passive- IVIG, FEEDING MOTHER- baby is just getting it and doesn’t do any work Acquired – body is fighting to make immunity. Working for it Natural – we produce it