Helminths_Lect 5.pdf

Helminths: Structure, Classification, Growth, and Development [email protected]  Helminths Helminth is a general term for a parasitic worm. The helminths include the Platyhelminthes or flatworms (flukes and tapeworms) and the Nematoda or roundworms. General charcteri...

Helminths: Structure, Classification, Growth, and Development [email protected]  Helminths Helminth is a general term for a parasitic worm. The helminths include the Platyhelminthes or flatworms (flukes and tapeworms) and the Nematoda or roundworms. General charcteristics All helminths are relatively large (> 1 mm long); some are very large (> 1 m long). They have well-developed organ systems and most are active feeders. The body is either flattened and covered with plasma membrane (flatworms) or cylindrical and covered with cuticle (roundworms). Some helminths are hermaphrodites; others have separate sexes. Transmission routes The mode of transmission varies with the type of worm Primary routes include: ✓ ingestion of eggs or larvae. Eg., Ascaris, Echinococcus, Enterobius, Trichuris or larvae (some hookworms) ✓ penetration by larvae Eg., hookworms, schistosomes, Strongyloides ✓ bite of vectors. Eg., the arthropod vectors of filarial worms ✓ ingestion of stages in the meat of intermediate hosts. Eg., Clonorchis in fish, tapeworms in meat and fish, Trichinella in meat NB: Worms are often long-lived.  Helminths are widely spread Infections caused by helminths may be serious in underdeveloped countries Factors influencing helminth infection Climate Hygiene Diet exposure to vectors. Classification of helminths Helminths are generally classified into two: ✓ Nematodes (Roundworms) ✓ Platyhelminths (Flatworms) - Trematodes (Flukes) - Cestodes (Tapeworms) Nematodes ✓ Cylindrical Shape and Bilateral Symmetry - Roundworms have an elongated, cylindrical body shape that tapers at both ends. - Their body is bilaterally symmetrical, meaning the left and right sides are mirror images of each other. ✓ Pseudocoelom and Digestive System - Nematodes have a body cavity called a pseudocoelom, which is a fluid-filled space between the body wall and digestive tract. - They have a complete digestive system with a distinct mouth and anus. ✓ Nervous and Sensory Systems - Roundworms have a nervous system with dorsal and ventral nerve cords. - They possess chemosensory organs called amphids on their lips for detecting chemical stimuli. ✓ Habitat and Feeding - Roundworms are found in diverse habitats including soil, freshwater, and marine environments. - Free-living species feed on bacteria, fungi, and other nematodes, while parasitic species infect plants and animals. ✓ Reproduction and Development - Nematodes can be dioecious (separate sexes) or hermaphroditic (having both male and female reproductive organs). - Fertilization is internal and reproduction is sexual. - Their cuticle molts periodically during development. ✓ Medical Importance - They cause diseases in humans and animals, such as ascariasis (Ascaris lumbricoides), hookworm infection (Ancylostoma duodenale), and elephantiasis or filariasis (Wuchereria bancrofti, Brugia malayi) Nematoda PLATYHELMINTHES Trematoda ✓ Body Shape and Symmetry - Trematodes have a flattened, oval or leaf-like body shape that is dorsoventrally compressed. - Their body is unsegmented and acoelomate (they lack a true body cavity). ✓ Suckers and Attachment - Flukes possess one or more suckers for attachment to the host. - The oral sucker is located near the mouth and helps in feeding, while the ventral sucker (acetabulum) serves only for attachment. ✓ Digestive System - Trematodes have a complete digestive system with a mouth, muscular pharynx, esophagus, and two blind-ending intestinal caeca. - They lack an anus, and waste is egested through the mouth. ✓ Reproduction and Life Cycle - Most trematodes are hermaphroditic, with both male and female reproductive organs in the same individual. - Their life cycle typically involves two or more hosts, with larval stages in mollusks and adults in vertebrates. - Alternation of generations between sexually reproducing adults and asexually reproducing larval forms is common. ✓ Excretory and Nervous Systems - Flukes have a branched excretory system with flame cells and a bladder that opens to the exterior. - Their nervous system consists of a pair of ganglia (cluster of nerve cells) and nerve cords running along the ventral surface. ✓ Medical and Veterinary Importance They can cause diseases in humans and animals, such as schistosomiasis (Schistosoma mansoni, S. haematobium, and S. japonicum), fascioliasis (Fasciola hepatica), and clonorchiasis (Clonorchis sinensis) NB: Preventive measures include controlling snail populations, treating infected individuals, and improving sanitation Trematoda Cestoda ✓ Body Shape and Segmentation - Cestodes have a flattened, ribbon-like body shape that is dorsoventrally compressed. - Their body is divided into segments called proglottids (individual segments of strobila), which contain the reproductive organs. - The body comprises a scolex (head), neck, and strobila (entire segmented body). ✓ Scolex and Attachment - The scolex is the anterior end of the tapeworm and serves as an attachment organ. - It may have suckers, hooks, or bothria (grooves) for attachment to the host's intestinal wall. - The scolex lacks a mouth or digestive system. ✓ Lack of Digestive System - Cestodes lack a digestive system and absorb nutrients directly from the host's intestine through their body surface. - Their specialized tegument (outer layer) facilitates nutrient absorption and gas exchange. ✓ Reproduction and Life Cycle - Cestodes are hermaphroditic, with both male and female reproductive organs in each proglottid. - They reproduce sexually, and the fertilized eggs are released from the gravid (egg-filled) proglottids. - Their life cycle typically involves one or more intermediate hosts, where the larval stages develop, and a definitive host (usually a vertebrate) where the adult worms reside. ✓ Medical Importance - Some cestodes are important human parasites, such as Taenia solium (pork tapeworm), Taenia saginata (beef tapeworm), and Diphyllobothrium latum (fish tapeworm). - Infections can cause gastrointestinal symptoms, malnutrition, and, in rare cases, serious complications like neurocysticercosis (T. solium larvae in the brain). - Prevention involves proper cooking of meat and fish, good hygiene, and deworming. Cestoda Life cycle of helminths Treatment and Management ✓ Pharmacological Treatment ✓ Community-Level Interventions - Commonly used antihelminthic drugs (e.g., - Mass drug administration (MDA) Albendazole, Mebendazole, Praziquantel) - Vector control programs ✓ Non-Pharmacological Management - Hygienic practices - Environmental control measures - Education and public health interventions ✓ Prevention and Control Personal Preventive Measures - Hygiene and sanitation - Proper cooking of food THANK YOU