HCC.pdf

Halogen Containing Organic Compounds Dr. Chathuranga Senarathna Halogen Containing Organic Compounds Halogen Halogen Containing Organic Compounds Fluorine Chlorine Bromine Iodine Astatine Tennessine Halogen Containing Organic Compound...

Halogen Containing Organic Compounds Dr. Chathuranga Senarathna Halogen Containing Organic Compounds Halogen Halogen Containing Organic Compounds Fluorine Chlorine Bromine Iodine Astatine Tennessine Halogen Containing Organic Compounds Alkyl Halide 5  Alkyl Halide R= any alkyl Group 6  Alkyl Halide Chloromethane 2-fluoropropane 2-bromobutane Methyl chloride 7 Nucleophilic Substitution Reaction 8 SN2 - - - + SN1 Intermediate product Carbo cation 9  SN2 Slow Reaction + - Fast Reaction SN1 10 Stability of carbocation Inductive effect Resonance effect 11 Elimination Reactions 12 In a polar solvent - Alcohol Medium + + H2O But in the non polar solvents above polarization is not observed. However, the induce effect leads to make +  charge on adjacent Hydrogen + 13 Reactions of Alkyl Halide 14 Grignard Reagent 15  Grignard Reagent Mg / Dry ether Alkyl Halides Grignard Reagent This is a Carbo Cation - act as a Nucleophile Any Halogen Therefore, Grignard reagent under goes nucleophilic reactions 16 Reactions of Grignard Reagent Acyl Halide 18 Acyl Halide 19 Aryl Halide 20  Aryl Halide X= F,Cl,Br and I Similar electrophilic substitution Reactions as benzene Slower than benzene. Because, the halogens are deactivate the benzene ring Electrophile is attached to the ortho or para position. Because, the halogens are ortho para directing group 21 End