Gastrointestinal Pharma Drugs PDF

GASTROINTESTINAL PHARMA DRUGS AFFECTING GASTRIC SECRETIONS LAXATIVES AND ANTIDIARRHEAL DRUGS ANTIEMETIC DRUGS  DRUGS AFFECTING GASTRIC SECRETION DRUGS FOR PEPTIC ULCER DISEASE, GASTRITIS AND GERD ANTACIDS H2 RECEPTOR BLOCKERS PROTON PUMP INHIBITORS ANTI PEPTIC DR...

GASTROINTESTINAL PHARMA DRUGS AFFECTING GASTRIC SECRETIONS LAXATIVES AND ANTIDIARRHEAL DRUGS ANTIEMETIC DRUGS  DRUGS AFFECTING GASTRIC SECRETION DRUGS FOR PEPTIC ULCER DISEASE, GASTRITIS AND GERD ANTACIDS H2 RECEPTOR BLOCKERS PROTON PUMP INHIBITORS ANTI PEPTIC DRUGS  LAXATIVES CHEMICAL LAXATIVE BULK LAXATIVES/OSMOTIC LAXATIVE STOOL SOFTENERS  ANTI DIARRHEAL DRUGS LOPERAMIDE OPIATE RELATED DIPHENOXYLATE WITH ATROPINE  ANTI DIARRHEAL DRUGS qDrowsiness, dizziness, dry mouth, dehydration qInhibits gastric motility qAlcohol is OUT qReport if there is a narcotic drug history qResponse to drug should be determined prior to driving qHabit forming, take only prescribed dose qElectrolytes- monitor with severe diarrhea; encourage clear liquids qAssess frequency of bowel movements; bowel sounds  ANTI EMETIC DRUGS PATHOGENESIS OF NAUSEA AND VOMITING CHEMORECEPTOR TRIGGER ZONE (CTZ)  ANTI EMETIC DRUGS Phenothiazines – suppress the vomiting center in the medulla Examples: Prochlorperazine, Promethazine Nonphenothiazine – reduce responsiveness of the cells in the CTZ to circulating chemicals to relieve vomiting Example: Metoclopramide Anticholinergics/Antihistamines – block transmission of impulses to CTZ, very good for client with vomiting due to vertigo. Examples: Buclizine, Cyclizine, Meclizine  ANTI EMETIC 5-HT 3 receptor blockers – block the receptors associated with nausea and vomiting both locally and centrally (CTZ) Examples: Dolasetron, Ondansetron Substance P/Neurokinin 1 Receptor antagonists – directly act in the CNS to block the receptors associated with nausea and vomiting little effect on serotonin , dopamine and corticosteroid receptors Example: Aprepitant Miscellaneous anti emetic drugs Trimethobenzamide HCl Hydroxyzine Dronabinol  ANTI EMETIC Monitor response of the client to the drug Provide safety if CNS effects occur Provide comfort measure including mouth care Provide adequate health teaching about the dug to increase client’s knowledge and good compliance