Fraser Lecture 1: Model Organisms & Development PDF
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Fraser
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These lecture notes discuss the use of model organisms for understanding fundamental biological principles, particularly in genetics, molecular biology, and development. The lecture covers concepts such as gene function, molecular components, and applying this knowledge to understand and treat human diseases.
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Model organisms — what are you trying to model? Discovery of basic principles How does gene+cs work? Discovery of molecular components Which genes affect...
Model organisms — what are you trying to model? Discovery of basic principles How does gene+cs work? Discovery of molecular components Which genes affect process X? e.g. iden+fy microRNAs, oncogenes, introns ‘Engineering’ Exactly how does EGF signalling work in humans? Can I iden+fy a small molecule antagonist of bcr-‐abl? Model organisms — what are you trying to model? Precise relevance Discovery of basic principles to human How does gene+cs work? disease treatment Discovery of molecular components Which genes affect process X? e.g. iden+fy microRNAs, oncogenes, introns ‘Engineering’ Exactly how does EGF signalling work in humans? Can I iden+fy a small molecule antagonist of bcr-‐abl? Development at single cell resolu+on Allows precise quan+ta+ve mutant phenotypes (e.g. vulva, cell death, cell divisions) Framework for interpre+ng phenotypes Nodes Func
