Assiut University Faculty of Pharmacy Pharm Organic Chem 1st Level Past Exam PDF

Assiut University Clinical Pharmacy, 1st level Faculty of Pharmacy Pharm. Organic Chem.(l) Final Exam Dept. Pharm. Organic Chem. Time allowed: 2 h Jan., 3, 2012 Illustrate your answers with chemical equations and reaction mechanisms...

Assiut University Clinical Pharmacy, 1st level Faculty of Pharmacy Pharm. Organic Chem.(l) Final Exam Dept. Pharm. Organic Chem. Time allowed: 2 h Jan., 3, 2012 Illustrate your answers with chemical equations and reaction mechanisms whenever possible This booklet is composed of 5 pages Answers should be in the specified places ‫المشاركون فى اﻻمتحان النظرى‬ Prof. Dr. Abdel Alim M. Abdel Alim Prof. Dr. Adel M. Kamal 1 2 III. Which of the following statements is not true?.............................(5 marks) a. The heterolysis of a bond between atoms which do not bear formal charges always produces a cation and an anion b. Carbon atoms of carbanions have a complete octet of valence shell electrons c. Nucleophiles seek centers of high electron density (e.g., a negative charge). d. Polarity of bond created due to the difference in electl'Onegativity of atoms forming bond. e. Zaitsev's rule: formation of the most substituted alkene is favored with a bulky base. f. CH2Ch was considered a non polar solvent and have zero dipole moment.. g. Ozonolysis of symmetrical alkenes produce single aldehydes. h. As the molecular mass of the compounds of the alkane series increases their boiling points decreases. i. The carbocation carbon is SP2 hypridized carbon. j. 1t bond in ethene was created by overlapping of SP3-SP3, P-P orbitals. Good luck Prof. Dr. Adel Mohamed Kamal 3  Section B (60 min. 25 points) 1- Complete the following statements OR mark (√) or (x) whenever required: (10 points) 1) SNl reaction proceeds through the formation of a transition state. ( ) 2) SN2 reactions proceed through back-side attack of nucleophiles to the leaving group of the appropriate substrate. ( ) 3) Alcohols have higher boiling points than the corresponding alkanes of the same molecular weights because....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 4) Alcohols have higher boiling points than ethers because...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 5)Primary alcohols are more acidic than tertiary ones. ( ) 6)Explain your answer of (5).................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 7) Addition of RMgX to aldehydes and ketones is a conventional method for preparation of alcohols. ( ) 8) The structure of 15-crown-5 ether is........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 9) Ethanol has higher hoiling point than ethanethiol. ( ) 10) Statement (9) is explained because......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... (see next page) 4 II- Complete equations 1-4 and answer question 5: (7.5 points) H+ 1- CH3-CHCH2 + H2O......................................................... - + 2- C6H5ONa + C2H5Br.......................................................... 3- CH3CH2CONH2 + NaOH + Br2............................................ 55°C 4- H3CHC CH2-CH3 + NaOC2H5..............................................  Br 5- How can you separate a mixture of ethylamine and diethylamine ( use equations) and very short notes......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... (see next page) 5 III- Given below are the relative rates of hydrolysis of some alkyl bromides (30, 0.00001, 1.0, 0.03 and 0.0). Anticipate each relative rate to the appropriate alkyl bromide. (7.5 points) Alkyl bromide Relative rate 1- (CH3)2-CH-Br............................. 2- CH3-Br............................. 3- CH3-CHrBr............................... 4- (CH3)]-C-CH2-Br................................. 5- (CH3h-C-Br................................ (GOOD LUCK) 6 Assiut University Faculty of Medicine Date: 10/1/2012 Medical Physiology Dept. Time allowed: 1 hour Final Exam of Biophysics For 1st Year Clinical Pharmacy Students First Semester, 2012. Answer the following question :- (Total marks:-65) First question:- a- Mention the characters of facilitated diffusion and discuss its (8) mechanism b- Describe factors affecting permeability of the membrane. (10) Second question:- a- Describe the depolarization stage and mention its causes. (7) b- How does the excitation of skeletal muscle occur (8) Third question:- a- Compare between isometric and isotonic muscle contraction. (8) b- Define: 1- latent period 2-ECG 3-Lead 4-EEG Fourth question:- - Give a short account on: a - P-R interval b - Alpha wave Good Luck Dr. Nashwa A Abd EI-Mottaleb and Dr. Azza Salah 7 Faculty of Science ‫ إعدادى صيدلة‬:‫امتحان الفرقة‬ Department of Zoology ‫ علم الخلية‬:‫المقرر‬ Exam: Cell Biology for MD 102 :‫رقم المقرر ورمزه‬ Clinical pharmacy students ‫ ساعة‬:‫الزمن‬ January- 14, 2012 ‫كلية العلوم – قسم علم الحيوان‬ ٢٠١٢ ‫ يناير‬١٤ I- Put (√) or (X) in front of the following sentences: (24 marks) 1 Steriod hormones-secreting cells are expected to be rich in rough endoplasmic reticulum. ( ) 2 DNA replication takes plece during S phase. ( ) 3 P53 is a tumor suppressor protein. ( ) 4 Highly dividing cancer cells are expected to have open face nuclei. ( ) 5 Nucleolus consists mainly of proteins, tRNA, DNA and certain enzymes. ( ) 6 Decoding of mRNA takes place in ribosomes. ( ) 7 The 1 ry transcripts of ribosomal RNA are located in ribosomes. ( ) 8 Melanin is an exogenous pigment and secreted by melanocytes. ( ) 9 Incoming transport vesicles enter the mature face of Golgi apparatus to be concentrated. ( ) 10 Drug inducing G2/M cell cycle arrest are expected to activate p21 death. ( ) 11 Bax upregulation lesds to induction of programmed cell death. ( ) 12 On apoptosis, Cytochrome C translocated from cytoplasm into the mitochondria. ( ) II- : Choose the correct answer: (24 marks) 1- Cell inclusions are (temporary - permanent - both). 2- Passive transport means transport from (high to low - low to high - need energy) concentration. 3- Residual body is (secondary - primary - both) lysosome. 4- Endocytosis done by (pseudopodia - autophagy - exocytosis). 5- Tail of phospholipids are (hydrophobic - hydrophilic - both). 6- Cells lack nuclear membrane are (prokayotic - eukaryotic - both). 7- Cell coat consists of (glycolipids - glycoprotein - both). 8- Apocrine secretion means that (apex - whole - base) of the cell exocytosed. 9- Phagocytic vesicle is a vacuole containing (solid material- enzymes - both). 10- Carrier proteins (change - fixed - rotate) their position during transport. 11- Antigens are located on the (cell coat - cell membrane - mitochondria). 12- One of the followings can penetrate the synthetic lipid bilayer easily (O2 - ethanol - Ca+2). III- Write briefly on the followings: (17 marks) A- Factors affecting the cell shape. (8.5 marks) B- Structure and functions of centriole. (8.5 marks) Best wishes Dr. Hanem Abdel Tawab Dr. Ismail Ismail 8 Faculty of Science Clinical pharmacy program Department of Mathematics First year Final Exam First Term 2011-2012 Course title: Math. & Statistics Total points:90 Course code: MS (101) Time: 2.0 hours Answer the following questions First Question:- (a) (Answer one item only) (6 points) (i) Find the second derivative of the function y = (x2 + 1)5. dy (ii) If eXY = 3xy2 , find ? dx (b) Integrate: (Choose 3 only) (9 points) e 1 3 x4 (i)  x e + dx, 2 (ii) (lnx) dx, 2 (iii)  x ln xdx , (iv)  8 x( x 2  1) 3 dx. 1 0 ( c ) (Answer one item only) (i) Find the intervals of increase and decrease and the relative extrema of the function (x) = x4 + 8x3 + 18x2 - 8. (ii) Find the area of the region bounded by the curves y = x2 + 1 and y = 2x - 2 between x = -1 and x = 2. Second Question:- (Answer 2 only) (20 points) a) Determine all the solution by using Gaussian elimination of the following system of equations: 2y + 4z = 3 , x - 3y + 5z = 1 , 3x - y - z = 1. 1 1 1 b) Find A-l and solve the homogeneous system Ax = 0, where A = 0 2 3 5 5 1 k-4 0 0 c) Find k such that 0 k 2 = 0. 0 3 k-1 ee the next page 9 Statistics Part: Answer Two Questions of the Following: (45 degrees) 1- (a) A town has 2 ambulances operating independently. The probability that a specific ambulance is available when needed is 0.96. What is the probability that: (i) An ambulance is available when needed, (ii) Neither is available when needed. (b) Determine the constant value C that makes the following function as a mass function C (x2 + 4), x = 0,1,2,3 f( x) = 0 ,o.w. Then, calculate (i) P(0