Drug Information 31-60

**\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Prednisone** Brand: - Deltasone Class: - Anti-inflammatory Dosage Form: - Tablet - Tablet DR - Solution FDA Indication: - Allergic states - Dermatologic diseases - Endocrine...

**\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Prednisone** Brand: - Deltasone Class: - Anti-inflammatory Dosage Form: - Tablet - Tablet DR - Solution FDA Indication: - Allergic states - Dermatologic diseases - Endocrine disorders - GI diseases - Hematologic disorders - Neoplastic diseases - Nervous system - Renal diseases - Respiratory diseases - Rheumatic disorder MOA: Patient Counseling: - Take with food or milk to prevent GI upset. - Take in the morning to help prevent insomnia. - If taking high dose/longer term treatment, monitor signs of hyperglycemia, osteoporosis, adrenocortical insufficiency, and infection. Clinical Pearls: - See national heart, lung, and blood institute guidelines for dosing. - After chronic use, taper down to continue therapy. - Metabolized in the liver. Common Adverse Side Effect: - GI upset **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Buspirone Hydrochloride** Brand: - Buspar Class: - Antianxiety Agent Dosage Form: - Tablet FDA Indication: - Anxiety MOA: - First class selective serotoning-5-HT1a receptor partial agonist and some effect on dopamine-D2 auto-receptor Patient Counseling: - Avoid activities requiring mental alertness. - Few weeks for symptoms to improve. - No sudden discontinuation - Avoid alcohol, grapefruit juice, MAOI Clinical Pearls: - Safety and efficacy not established in patients, 18 y - Don't use in as needed basis. Common Adverse Side Effect: - Dizziness **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Zolpidem Tartrate** Brand: - Ambien - Ambien CR - Class: - Sedative Dosage Form: - Tablet - Tablet ER - Sublingual Tablets - Oro mucosal Spray FDA Indication: - Insomnia MOA: - Binds to Benzodiazepine Patient Counseling: - Take on an empty stomach. - May cause daytime drowsiness. - Avoid activities that require mental alertness. - No alcohol - Discontinue is experiencing sleep-driving. - Bed partner should monitor. Clinical Pearls: - Not for long term use (7-10 d) - Caution and dose reduction in elderly - Can take with CNS depressant with caution. - Immediate release: reduce dose from 10 to 5 mg and from 12.5 to 6.25mg - Use with caution in those with impaired respiratory function and COPD. Common Adverse Side Effect: - Dizziness - Drowsiness - Headache **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Lorazepam** Brand: - Ativan Class: - Antianxiety Agent Dosage Form: - Tablet - Capsule ER - Solution FDA Indication: - Anxiety - Insomnia MOA: - Enhance the postsynaptic effect of the inhibitor neurotransmitter, GABA. Patient Counseling: - May cause drowsiness. - Avoid driving/ other motor coordination task. - No Alcohol Clinical Pearls: - Don't use with opioids. - Use with caution in elderly: dose reduce. - Avoid abrupt discontinuation after chronic use. - Not first line therapy Common Adverse Side Effect: - Drowsiness - Impaired motor coordination - Retrograde amnesia **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Meloxicam** Brand: - Mobic Class: - Nonsteroidal Anti-inflammatory Dosage Form: - Tablet - Capsule - Suspension FDA Indication: - Osteoarthritis - Rheumatoid arthritis - Juvenile rheumatoid arthritis MOA: - Nonselective inhibitor of COX-1 and COX-2 which causes a decrease in prostaglandins. Patient Counseling: - Take with food or milk to decrease GI. - Suspension: shake gently - Don't use in 20 wk gestation. - Pregnant women should consult HCP. Clinical Pearls: - Elder patient is at increase of GI ulcers. - Use lowest dose for short time. Common Adverse Side Effect: - GI distress **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Clonazepam** Brand: - Klonopin Class: - Antianxiety Agent Dosage Form: - Tablet - Disintegrating Tablet FDA Indication: - Seizures MOA: - Enhances the postsynaptic effect of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Patient Counseling: - May cause drowsiness. - Avoid activities that require mental alertness. - Avoid alcohol. - Disintegrating tablet- dissolve on your tongue Clinical Pearls: - Avoid use in elder. - Use CNS depressant with caution. - Avoid in combination with opioids. - No abrupt discontinuation after chronic use: may cause seizures. Common Adverse Side Effect: - Ataxia (lack of muscle and balance coordination) - Lethargy - Somnolence - Weight gain **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Alprazolam** Brand: - Xanax Class: - Antianxiety Agent Dosage Form: - Tablet - Disintegrating tablet - ER tablet - Solution FDA Indication: - Anxiety - Panic disorder MOA: - Enhances the postsynaptic effect of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA). Patient Counseling: - Causes drowsiness. - Avoid activities that require mental alertness. - Avoid alcohol. - Do not crush tablets. - Can mix in solution in liquid and semi-solid food. - Discard ½ tablet if only taking half of the tablet. Clinical Pearls: - Not for use in children - Reduce dose in hepatic impaired. - Avoid us in elder. - Has addictive effect - Avoid abrupt discontinuation after chronic use. - May cause seizures. Common Adverse Side Effect: - Ataxia - Lethargy - Retrograde amnesia - Somnolence - Weight gain - Change in appetite. - Constipation - Fatigue - Cognitive dysfunction - Decrease libido. **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Quetiapine Fumarate** Brand: - Seroquel Class: - Antipsychotic Dosage Form: - Tablet - ER tablet. FDA Indication: - Bipolar disorder or schizophrenia MOA: - Antagonizes 5-HT1a and 5-HT2 dopamine D1 and D2, Histamine H1 and Adrenergic α~1~ and α~2~ receptors. Patient Counseling: - Take with food. - Avoid alcohol. - Avoid activities that require mental alertness. - Rise slowly from sitting up. - Report sign and symptoms of hyperglycemia, bradycardia, arrythmia, tardive dyskinesia or neuroleptic malignant syndrome Clinical Pearls: - Avoid concomitant use with opioids. - Elder patients with dementia-relates psychosis taking quetiapine are increased risk of death compared to placebo. Common Adverse Side Effect: - Agitation - Headache - HTN - Somnolence - Weight gain - Xerostomia **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Metoprolol Tartrate** Brand: - Lopressor Class: - Antihypertensive Dosage Form: - Tablet - ER tablet. - ER capsule. - 24h Sprinkle FDA Indication: - Angina - HF with reduced ejecting fraction - HTN - AMI MOA: - Cardio selective β-adrenergic blocker Patient Counseling: - Take on an empty stomach. - Avoid alcohol. - Avoid abrupt discontinuation. - Report sight and symptoms of hypotension heart failure or exacerbation of angina - In diabetics, this drug may mask symptoms of hypoglycemia. Clinical Pearls: - Limit use of calcium channel blockers - Injectable metoprolol is also use in atrial fibrillation patient. - Conversion from IV to PO - 2.5mg po to 1 mg IV Common Adverse Side Effect: - Dizziness - Fatigue - Hypotension **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Tamsulosin Hydrochloride** Brand: - Flomax Class: - BPH agent Dosage Form: - Oral capsule FDA Indication: - Benign prostatic hyperplasia MOA: - electively block postsynaptic α~1~-adrenergic receptors. Patient Counseling: - Administer 30 min after the same meal daily. - Avoid activities that require coordination. - May cause vertigo and dizziness. - Rise slowly from sitting down. - Syncope or loss of consciousness is possible after 1^st^ dose. Clinical Pearls: - Not first line - Have longer half life - May result in hypotension less often than other agents. Common Adverse Side Effect: - Dizziness - Headache - Abnormal ejaculation - Rhinitis **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Oxycodone Hydrochloride** Brand: - OxyContin - Roxicodone Class: - Opioid Analgesic Dosage Form: - Capsule - Tablet IR - Tablet ER 12 h abuse- deterrent - Solution - Concentrate FDA Indication: - Pain (chronic/moderate/severe) MOA: - Mu agonist Patient Counseling: - Use laxative to prevent constipation. - May cause drowsiness. - No task that requires motor coordination - Avoid alcohol or other CNS depressants. Clinical Pearls: - Tolerance and dependence may occur. - Avoid abrupt discontinuation. - No crushing tablets. - ER- don't use in children. - Don't use with benzodiazepines. - Use combo or acetaminophen due to beneficial pain management. - FDA requiring update to opioid labeling. Common Adverse Side Effect: - Constipation - GI distress - Sedation - Sweating - Pruritus **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Fluticasone Propionate (nasal)** Brand: - Flonase Class: - Antiallergy agent Dosage Form: - Nasal spray - Nasal exhaler suspension FDA Indication: - Allergic rhinitis - Non allergic rhinitis - Nasal polyps MOA: - Corticosteroids - Anti-inflammatory - Antipruritic - Vasoconstrictive Patient Counseling: - Show patients how to properly administer. - Monitor for signs and symptoms of toxicity. - May have a scent. - Relief or adverse effect may occur for several days after first use. Clinical Pearls: - OTC - Topic and inhalation also available for treatment of asthma and other allergic disorders Common Adverse Side Effect: - Headache - Nasal irritation - Burning **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Donepezil** Brand: - Aricept Class: - Alzheimer's Dementia Agent Dosage Form: - Tablet - Disintegrating tablet FDA Indication: - Alzheimer disease - Dementia MOA: - Central cholinesterase inhibitor Patient Counseling: - Take at bedtime with or without food. - Adverse effect may be more frequent at dose escalation and will resolve when continued Clinical Pearls: - Safety and effectiveness not established in children. - No evidence shows that it alters the course of Alzheimer's. Common Adverse Side Effect: - Asthenia -- weakness or loss of strength **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Clopidogrel Bisulfate** Brand: - Plavix Class: - Hematological Agent Dosage Form: - Tablet FDA Indication: - Acute ST Segment elevation Mi managed - Thrombosis prevention in ASCVD MOA: - Platelet aggregation inhibitor Patient Counseling: - Report signs and symptoms of bleeding - Do not stop therapy abruptly. Clinical Pearls: - Discontinue 5 days prior to elective surgery if antiplatelet is or desired. - Actively metabolized by CYP2C19 Common Adverse Side Effect: - Headache **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Methylphenidate** Brand: - Ritalin - Methylin - Metadate - Concentra Class: - CNS agent for ADHD Dosage Form: - Tablet - Chewable tablet - Chewable tablet ER - Tablet ER - Disintegrating tablet ER - Tablet ER 24 hours - Capsule ER - Capsule ER 24 h - Solution - Suspension - Patch - Transdermal patch FDA Indication: - ADHD - Narcolepsy MOA: - CNS stimulant C-II Patient Counseling: - Avoid taking it at night as it may cause insomnia. - Avoid abrupt discontinuation. - Patch: apply same time each day and alternating hips. Remove 9 h Clinical Pearls: - High potential for abuse - Consider drug holidays. - Avoid confusion of multiple different brand names and formulations Common Adverse Side Effect: - Weight loss - Loss of appetite. - Headache - Insomnia - Irritability **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Allopurinol** Brand: - Zyloprim Class: - Gout agent Dosage Form: - Tablet FDA Indication: - Gout - Hyperuricemia - Nephrolithiasis MOA: - Xanthine oxidase inhibitor - Decreases the production of uric acid. Patient Counseling: - Take after meal. - Maintain adequate hydration. - Should avoid alcohol and caffeine. - Seek medical attention if. - Myelosuppression - Agranulocytosis - Steven Johnson syndrome Clinical Pearls: - Full effect in chronic gout may take 2--6-week, slow dose titration. Common Adverse Side Effect: - None known. **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Risperidone** Brand: - Risperdal Class: - Antipsychotic Dosage Form: - Tablet - Dispersible tablet - Solution FDA Indication: - Autistic disorder - Acute manic or mixed episodes of bipolar I - Schizophrenia MOA: - Serotonin 5-HT2 antagonist with weaker dopamine antagonism Patient Counseling: - Take with food. - Avoid alcohol and other CNS depressants. - Avoid activities that require mental alertness or coordination. - Rise slowly from a sitting or supine position - Report sign and symptoms of hyperglycemia - Can be mixed in coffee, orange juice and low-fat milk but not in cola or tea. Clinical Pearls: - Monitor closely for dyskinesia. - Increase risk of death in elderly patients with dementia related psychosis Common Adverse Side Effect: - Extrapyramidal symptoms - Insomnia - Anxiety - Fatigue - Metabolic changes **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Lamotrigine** Brand: - Lamictal XR, ODT, DC Class: - Anticonvulsant/ bipolar Dosage Form: - Oral chewable tablet - Tablet - Tablet ER - Dispersible tablet FDA Indication: - Bipolar I disorder. - Partial seizures MOA: - Inhibits voltage dependent sodium channels. - Phenyl triazine anticonvulsant Patient Counseling: - Seek medical attention is blistering rash develops or yellowing of skins and eye. - Avoid alcohol. - Slow titration to minimize side effects. - Talk to pcp is planning to become pregnant. Clinical Pearls: - Rash in children might happen 2-8 w after stat of therapy. - Patients should pay attention to tablet to reduce medication error. Common Adverse Side Effect: - Rash - Ataxia - Somnolence - Headache - diplopia - Rhinitis - Nausea - Vomiting - Insomnia **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Memantine hydrochloride** Brand: - Namenda Class: - Alzheimer's dementia agent Dosage Form: - Solution - Tablet - Oral ER FDA Indication: - Alzheimer's disease MOA: - N-methyl d aspartate receptor antagonist Patient Counseling: - May be taken with or without food. Clinical Pearls: - Slows progression of Alzheimer's disease but does not reverse it - Starter pack with multiple strength available - Common Adverse Side Effect: - None **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Diltiazem hydrochloride** Brand: - Cardizem - Cartia - Dilacor - Dilt-XR - Tiazac Class: - Antihypertensive Dosage Form: - Tablet - Capsule ER 12 h - Capsule ER24h - Tablet ER 24 h FDA Indication: - HTN - Stable chronic angina - Atrial arrhythmia MOA: - Calcium channel blocker Patient Counseling: - Report sign and symptom of hypotension bradyarrhythmia, edema and syncope - Do not drink alcohol. - Administer at the same time of day. Clinical Pearls: - Do not use with beta blockers or digoxin. Common Adverse Side Effect: - Edema - Headache **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** Generic: - Cyclobenzaprine Hydrochloride Brand: - Flexeril - Amrix - Fexmid Class: - Muscle Relaxant Dosage Form: - Tablet - Capsule ER FDA Indication: - Skeletal muscle spasm MOA: - Centrally acting skeletal muscle relaxant Patient Counseling: - Avoid activities that require mental alertness. Clinical Pearls: - Should be used only for short period of time (2-3 w) - Avoid use with opioids. - Avoid use in elderly. Common Adverse Side Effect: - Xerostomia - Headache - Dizziness - Drowsiness **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Lisdexamfetamine Dimesylate** Brand: - Vyvanse Class: - CNS agent for ADHD Dosage Form: - Capsule - Chewable tablet FDA Indication: - ADHD - Binge eating disorder. MOA: - Pro drugs - Amphetamine CNS stimulant C-II Patient Counseling: - Take dose in the morning with or without food. - Can be dissolved in water yogurt or orange juice. - Report any chest pain, palpitations, dyspnea. Clinical Pearls: - High potential for abuse - A complete family and patient history of serious CV adverse events is required before administration. Common Adverse Side Effect: - Insomnia - Irritability - Loss of appetite - Upper abdominal pain - Xerostomia **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Oxybutynin Chloride** Brand: - Ditropan - Ditropan XL Class: - Urinary bladder modifier Dosage Form: - Tablet - Tablet ER - Syrup - Transdermal gel FDA Indication: - Overreactive or neurogenic bladder MOA: - Competitive muscarinic receptor antagonist Patient Counseling: - Nothing important Clinical Pearls: - Be cautious in decision to engage in potentially dangerous activities until drug effects have been determined. Common Adverse Side Effect: - Constipation - Xerostomia - Blurred vision **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Mirtazapine** Brand: - Remeron Class: - Antidepressant Dosage Form: - Tablet - Disintegrating tablet FDA Indication: - Depression MOA: - α~2~ antagonist Patient Counseling: - take in the evening prior to sleep. - take medication once take out of blister packet. Clinical Pearls: - Cautious in elder - Avoid abrupt discontinuation. - QTC prolongation or torsade de pointes have been reported. Common Adverse Side Effect: - Constipation - Increased appetite - Somnolence - Xerostomia - Increased serum cholesterol - Weight gain **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Potassium chloride** Brand: - Klor-con - K-dur - Micro-k Class: - Electrolyte Dosage Form: - Tablet ER - Capsule ER - Powder - Solution FDA Indication: - Hypokalemia MOA: - Electrolyte needed for maintenance of the excitatory properties of neuromuscular tissue. Patient Counseling: - Take with food. - Sip over 5-10 min period - Can be mixed in apple sauce. Clinical Pearls: - Content of potassium: 70 kg male = 3500 mEq - B-agonist or insulin may decrease potassium levels. - 750 mg potassium chloride = elemental potassium 390 mg = potassium 10 mEq = potassium 10 mmol. Common Adverse Side Effect: - Nausea - Indigestion - flatulence **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **spironolactone** Brand: - Aldactone Class: - Diuretic Dosage Form: - Tablet - Suspension FDA Indication: - Ascites, cirrhosis of liver - Acne vulgaris - Hirsutism MOA: - Potassium-sparing diuretic - Selective aldosterone blocker Patient Counseling: - Avoid activities that require mental alertness. - Report sign and symptoms of hyperkalemia, hyponatremia - Avoid potassium supplements. - Avoid alcohol and NSAIDS. Clinical Pearls: - Lower dose when used in combination with other diuretics. - Tablet smell like peppermint Common Adverse Side Effect: - N/A **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Divalproex sodium** Brand: - Depakote (ER) Class: - Anticonvulsant - Bipolar agent Dosage Form: - Tablet ER - Tablet DR - Capsule DR sprinkles - Solution FDA Indication: - Absence seizures - Complex partial epileptic seizures - Manic bipolar disorder - Migraine prophylaxis MOA: -  composed of sodium valproate and valproic acid Patient Counseling: - Avoid activities that require mental alertness. - Take with food to avoid GI irritation. - Do not discontinue drug abruptly. - Sprinkle capsule may be sprinkled on soft food. Clinical Pearls: - Use at the same time every day. - Use in caution in women of childbearing age cause its teratogenic Common Adverse Side Effect: - Abdominal pain - Alopecia - Asthenia - Diarrhea - Diplopia - Dizziness - Headache - Nausea - Somnolence - Tremor - vomiting **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Cephalexin Monohydrate** Brand: - Keflex Class: - Antibiotic Dosage Form: - Powder for oral suspension - Tablet - Capsule FDA Indication: - Infection of skin - Osteomyelitis - Otitis media respiratory tract infection - Streptococcal pharyngitis - impetigo, ecthyma - Cellulitis MOA: - 1st-generation cephalosporin that inhibits bacterial wall synthesis of actively dividing cells by binding to ≥1 penicillin-binding proteins (PBPs) Patient Counseling: - Seek medical attention is rash develops. - Avoid mixing suspension with food or beverages. Clinical Pearls: - May resume normal activities after 24 h of antibiotics. - Is allergic to penicillin may also be allergic to this drug. Common Adverse Side Effect: - Nausea **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_** **Generic:** - **Ondansetron hydrochloride** Brand: - Zofran Class: - Antiemetic Dosage Form: - Tablet - Dispersible tablet - Solution FDA Indication: - Chemotherapy-induced nausea and vomiting - Prevention of postoperative nausea and vomiting - Radiation-induced nausea and vomiting MOA: - selective 5-HT~3~ receptor antagonist Patient Counseling: - dry hands before handling medication Clinical Pearls: - disintegrating tablet, and solution are bioequivalent and are dosed interchangeably. - usually combined with other antiemetics Common Adverse Side Effect: - Constipation - Diarrhea - Headache **\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_**