Drug Index P1 PDF

Vetscraft.com Crafting veterinary science at glance DRUG INDEX P1 1|Vetscraft.com Credits This veterinary drug formulary was initially prepared to assist veterinarians in treating animals in the Republic Georgia. In order to expand its use, this current edition is written in the Russian language. This formulary is meant to provide a readily available and practical source of drug information for use in veterinary practice. Medicines are listed by generic drug names. Other brand names are also listed. This formulary contains a list of pharmaceutical and biological items and suggested doses for routine use in treating animals. Users of this drug formulary should be aware that for most drugs there is a range of acceptable doses. An attempt has been made to list dose rates for the different species in mg/kg but in some cases the formulary will list it as a dose range or average dose per animal. Average dose per animal is not preferred, but may be the only dosing information available. One tablet tid for a dog refers to an average size (14kg dog) a dose range of 15-30 mls for a cow would mean that 15 mls would be given to a small cow (230-275 kg) whereas 30 mls would be given to a large (450-550 kg) cow. Any confusion about dosage, use, or form of administration, please conduct an Internet search or consult veterinary pharmacy texts. Please make sure to observe any and all withdrawal times listed on the drug label for all food animal species. We sincerely hope our veterinary colleagues in the Russian speaking countries will find this formulary useful. Please feel free to contact us via email with any suggestions, comments or questions. Compiled by: Katie Steneroden DVM, MPH, PhD Ed Wydallis DVM Buckhorn Veterinary Animal Population Health Institute Practice Fort Collins, CO 80521 Colorado State University USA Fort Collins, CO 80521 USA [email protected] [email protected] Sources: Formulary of the CSU VTH, Plumb. 2|Vetscraft.com Abbreviations used in prescription writing SID – once daily BID – twice daily TID- three times daily QID – four times daily IV- intravenous IM - intramuscular SQ - subcutaneous PO – per os (by mouth) Acepromazine maleate Other names: acetylpromazine maleate, ACE, Notesil, Atravet Use: Tranquilizer, preanesthetic, sedative Dose form: 10mg/ml, 50 ml vial Dose: Horse 0.01 – 0.08 mg/kg IV, IM, SQ Cattle 0.05 - 0.1 mg/kg IV, IM, SQ Swine 0.03 – 0.2 mg/kg IV, IM, SQ Dog, cat 0.03 – 0.25 mg/kg IV, IM, SQ, Dog, cat 1.1 – 2.2 mg/kg PO Note: Lower dose by IV route, higher doses by IM or SQ route. Maximum dose 3 mg/dog and 1 mg/ cat Amoxicillin Other names: amoxicillin, p-hydroxyampicillin, BRL, Amoxil Use: Broad spectrum antibiotic Dose form: Oral 50,100,200,400mg/tablets 50 mg/ml suspension, 15 ml bottle Dose: Dog, cat 10-20 mg/kg once per day up to 3 times per day Note: 3|Vetscraft.com Aspirin Other names: ASA, acetylsal acid, acetylsalicylic acid, acidum acetylsalicylicum, polopiryna, or salicylic acid acetate Use: Analgesic, antipyretic, anti-inflammatory Dose form: Oral 81mg/tab 325 mg/tab Dose: Horse 25 mg/kg bid first day, then 10 mg/kg daily Swine 10 mg/kg q 6 hours Bovine, Ovine 50-100 mg/kg q 12 hours Dog 10-25 mg/kg q 12 hours Cat 10 mg/kg every other day Note: Give with food. Discontinue use if signs of gastric upset occur. Atropine Other names: atropine sulfate Use: Preanesthetic, bradycardia, organophosphate antidote Dose form: Injectible 0.5 mg/ml ,15 mg/ml Dose: Dog, cat 0.02-0.04 mg/kg IV, SQ, IM Dog, cat: organophosphate 0.2-0.5 mg/kg. Give ¼ of dose IV and the poisoning rest IM or SQ Note: Bismuth Subsalicylate Other names: bismuth oxysalicylate, bismuth salicylate, Bismatrol, Bismed, Bismylate, Bisval, Jatrox, Kalbeten, Kaopectate, Katulcin-R, Peptic Relief, Pink Biscoat, Pink Bismuth rose, Ulcolind Wismut. Use: Anti-diarrheal Dose form: Oral suspension 1.75% (17.5 mg/ml) Dose: Horse, Bovine 6-10 ounces every 2-3 hours Foals, calves 100ml tid-qid Dogs 1 ml/5kgs tid up to 5 days Piglets 2-5 mls, bid-qid for 2 days Note 4|Vetscraft.com Butorphanol Other names: Butorphanol tartarate, torbugesic, torbutrol, levo-BC-2627. Use: Analgesic, preanesthetic, antitussive Dose form: Injectible 10/mg/ml, 50 ml vial Oral 5 mg tablets Dose: Horse 0.02-0.05 mg/kg IV Cattle 0.05 mg/kg q 6-8 hours IV Dog-analgesic 0.1-1.0 mg/kg IV IM, SQ, PO q 1-4 hours Dog-preanesthetic 0.05mg/kg IV 0.2-0.4 mg/kg IM Dog-antitussive 0.5-1.0 mg/kg PO tid-qid Cat-analgesic 0.1-1.0 mg/kg IV, IM, SQ q 1-3 hr Cat-preanesthetic 0.25-0.5 mg/kg SQ or IM Note: Use lowest dose for IV. Withdrawal meat 38 hours, milk 48 hours. Chloramphenicol Other names: chloramphenicol sodium succinate, chloramphenicolum, chloranfenicol, cloranfenicol, kloramfenikol, laevomycetinum. Use: Broad spectrum antibiotic Dose form: Oral 250 mg and 500 mg tabs Injectible 1 gm vial Dose: Horse 100 mg/kg PO initial, 50 mg/kg tid Dog 25-60 mg/kg IV, IM, SQ, PO tid Cat 25-50 mg/kg PO, IV, IM, SQ bid-qid Note: Cannot be used in animals used for food. Do not use in young or pregnant animals. Wear gloves with powder, can cause fatal aplastic anemia in humans. Chorionic gonadotropin (HCG) Other names: CG, choriogonadotrophin, chorionic gonadotrophinium, chorionicum, gonadotropinum chorionicum, HCG, hCG, human chorionic gonadotrophin, pregnancy- urine hormone, PU, Follutein. Use: Lutenizing hormone, increase libido, cystic ovaries, induce ovulation Dose form: Injectible 1000 units/ml, 10 ml Dose: Horse Bovine 1,000-5,000 units IV, 10,000 units IM Sheep 250-500 units, IV, 2,000 units IM Note: Read the label for dosage instructions. 5|Vetscraft.com Dexamethasone Other names: Azium, Decadron, desamethsone, dexametasone, dexamethasonum, 9alpha- Fluoro-16alpha-methylprednisolone, hexadecadrol. Use: Corticosteroid therapy Dose form: Injectible 2 mg/ml, 100 ml vial Injectible 4 mg/ml Oral 4 mg tablet Dose: Horse, bovine, swine 0.1 mg/kg IM Dog, cat 0.28 to 2.2 mg/kg PO or IM Note: May induce parturition in horse, bovine, swine, ovine, caprine. 4 mg/ml is Dexamethasone sodium phosphate for IV use only. Dosage will vary with condition being treated. Always consult relevant literature to determine proper dosage and duration of therapy. Dextrose Use: Nutrition, treatment of hypoglycemia, ketosis Dose form: Powder Injectible 50%, 50 and 500 ml vial Dose: Adult bovine 500 ml 50% solution IV or SQ Sheep 200 ml 50% solution IV or SQ Horse 500 ml 50% solution IV or SQ Pediatric dog, cat 1-5 ml 50% solution SQ Note: Approximately 4 calories per gram of dextrose. Once bottle is penetrated, refrigerate and use remaining contents within 48 hours. Discard after 48 hours. Doxycycline Other names: doxycycline monohydrate, doxycyclinum, GS-3065, Vibramycin, Doryx, Monodox, Periostat, Vibra-Tab, Doxirobe Use: Long acting, broad spectrum tetracycline Dose form: Oral 100 mg tablet (Suspensions often compounded from tablets) Dose: Horse 10 mg/kg PO bid Avian 22-50 mg/kg PO bid Dog, Cat 5-10 mg/kg PO once daily to bid Note: 6|Vetscraft.com Other names: Adrenaline Use: Cardiac resuscitation, acute allergic reactions (anaphylaxis) Dose form: Injectible 1:1000 solution, 30 ml vial Dose: Horse-resuscitation (foal) 0.01-0.02 mg/kg 1:1000 solution IV q 3 minutes Horse-anaphylaxis 3-5 ml per 450kg IM or SQ Bovine - anaphylaxis 0.5-1.0 ml/45 kg 1:1000 solution IM or SQ q 15minutes Sheep, swine - anaphylaxis 1-3 ml 1:1000 solution IM or SQ Dog, cat-resuscitation 0.5-5ml 1:10,000 solution IV or IT Dog , cat- anaphylaxis 0.01-0.02mg/kg 1:10,000 IV, IM, SQ Note: To make 1:10,000 concentration, dilute 1 ml of 1:1,000 solution with 9 ml normal saline. Erythromycin Other names: eritromicina, erythromycinum, Use: Macrolide antibiotic Dose form: Oral 250 mg tabs Dose: Foal 22 mg/kg PO bid-qid Dog, cat 11-22 mg/kg PO tid with a small amount of food 7|Vetscraft.com Fenbendazole Other names: Panacur, Hoe-881V, Safe-Guard Use: Antihelmintic Dose form: Oral 10% solution, 1000 ml bottle Dose: Horse 5 mg/kg PO once daily for 5 days for small and large strongyles, pinworms 10 mg/kg PO once daily for 5 days for control of ascarids Cattle 5-7.5 mg kg Swine 5 mg/kg once daily for 3 days Sheep and goats 5 mg/kg once daily for 3 days Dog (for Ascarids, 50 mg/kg PO daily for 3 days hookworms, whipworms, Giardia) Cat (for Ascarids, 50 mg/kg PO daily for 3 days Giardia) Note: Repeat treatment in 3 weeks and again in 3 months. Consult the label for dosages. Firococib Other names: equioxx, previcox Use: Analgesic, anti-inflammatory Dose form: Equine paste 0.82% paste (6.93 gm tube) Canine tablet 57 mg and 227 mg chewable tablet Dose: Horse Loading dose 0.3 mg/kg day 1, then 0.1 mg/kg once daily for up to 14 days Dog 5 mg/kg q 24 hours Note: 8|Vetscraft.com Florfenicol Other names: Nuflor, Sch-25298 Use: Broad spectrum antibiotic Dose form: Injectible 300 mg/ml, 100 ml vial Dose: Bovine 20 mg/kg IM followed by a second dose 48 hours later. 40 mg/kg sq as a single injection Sheep/goats 20 mg/kg once a day for 2 days. Dog 25-50 mg/kg IM, SQ once daily for 3-5 days Cat 25-50 mg/kg IM, SQ bid for 3-5 days Note: Give only in neck musculature, not more than 10 ml per site. Meat withdrawal IM 28 days, SQ 38 days Fluconazole Other names: UK-49858, Diflucan Use: Antifungal Dose form: Oral 100 mg tablets Dose: Dog 2.5-5 mg/kg q 24 hour PO for 56-84 days Cat 2.5-10 mg/kg q 24 hour PO Avian 5-10 mg/kg q 24 hour PO for 6 weeks Note: Flunixin meglumine Other names: 3-pyridine-carboxylic acid, Sch-14714, Finadyne, Banamine, Use: Anti-inflammatory, analgesic Dose form: Injectible 50 mg/ml, 100 ml vial Oral 1.5 gm paste syringe Dose: Horse 1.1 mg/kg IV, IM once daily up to 5 days. Cattle 1.1-2.2 mg/kg IV, IM once daily up to 5 days. Dog 0.5-2.2 mg/kg IM or IV one time only Note: Withdrawal IV: meat 4 days, milk 72 hours. IM or SQ: meat 10 days, mile 120 hours. 9|Vetscraft.com Furosemide Other names: Lasix, Salix, frusemide, furosemidum, LB-502. Use: Diuretic Dose form: Injectible 50 mg/ml, 100 ml vial Oral 12.5, 50 mg tabs; 10 mg/ml solution, 60 ml Dose: Horse, bovine 0.5-1.0 mg/kg IM or IV 2.2 – 4.5 mg/kg daily, PO Dog, cat 2.2-4.4 mg/kg PO, IV,IM once daily to bid Note: Gentamicin Other names: Gentamicin sulphate, gentamicini sulfas, NSC-82261, Sch-9724. Use: Aminoglycoside antibiotic Dose form: Injectible 100 mg/ml 50mg/ml Dose: Horse, dog 6.6 mg/kg as a single daily dose IM, IV or SQ Note: Do not use in animals used for food. If given IV administer slowly. Beware of nephrotoxicity with prolonged use. Gonadorelin Other names: follicle stimulating hormone-releasing factor, GnRH, gonadoliberin, gonadorellinum, gonadotrophin-releasing hormone, Hoe--471, Lh/FSH-RF, Lh/Fsh-RH, LH-RF, LH-RH, luliberin, luteninising hormone-releasing factor, Cryptocur, Fertiral, HRF, Kryptocur, LRH, Luforan, Luteoliberina, Lutrefact, Parlib, Pulsti, Relefact LH-RH, Stimu-LH Use: Treat cystic ovaries and other reproductive disorders Dose form: Injectible 50 mcg/ml, 10 ml vial Dose: Bovine 100 mcg/cow, IM or IV Dog 50-100 mcg IM daily for 3 days Note: May be used in place of HCG 10 | V e t s c r a f t. c o m Iron Dextran Other names: iron dextran complex, Cosmofer, Deciron, Driken, Fercayl, Ferrocel, Ferroin, Ferrum Hausmann, Fexiron, Imferdex, Imferon, Infufer. Use: Injectible hematinic Dose form: Injectible 100 mg iron/ml, 100 ml vial Dose: Horse, bovine, sheep 2.22 mg/kg IM piglets 200 mg IM repeat in 10-14 days (treatment) 100-150 mg IM from 1-3 days (prevention) Dog, cat 11-22 mg/kg once Note: Ivermectin Other names: Ivomec, Equimax, Eqvalan, Meltra, Mectizan, Revectina, Securo. Use: Anti-parasiticide Dose form: Injectible 10 mg/ml (1%), 2.7 mg/ml (.27%) Oral paste 18.7 mg/gm (1.87%) Oral tablets 55,68,136,165 mcg Pour-on 5mg/ml Dose: Horse 0.2 mg/kg PO Bovine-Injectible 0.2 mg/kg SQ as a single dose Swine-injectible 0.3 mg/kg SQ as a single dose Canine – sarcoptes scabiei or 0.3 mg/kg SQ or PO, repeat in 14 days. otodectes cynotis infestations. Canine – demodicosis 0.3-0.4 mg/kg PO daily , 2-4 months Note: 10 mg/ml (1%) Injectible form can be given orally to canines as treatment for scabies or demodectic mange. 11 | V e t s c r a f t. c o m Ketamine hydrochloride Other names: CI-581, CL-369, CN-52372-2, ketamini hydrochloridum, Brevinaze, Calypsol, Cost, Inducmina, Keta, Keta-Hameln, Ketalin, Ketanest, Ketava, Ketina, Ketmin, Ketolar, Velonarcon, Ketaset, Ketaved, Vetalar Use: Anesthesia Dose form: Injectible 100 mg/ml, 10 ml vial Dose: Horse 2 mg/kg IV, 5 minutes following 1 mg/kg IV xylazine swine 6-11 mg/mg IM after or in conjunction with sedative/tranquilizer Dog 10-21 mg/kg IM 2.2-4.4 mg/kg IV cat 6-10 mg/kg IV Restraint: 11 mg/kg IM Anesthestia: 22-33 mg/kg IM Note: In horse use only in conjunction with xylaxine. Extralabel suggested withdrawal time: meat 3 days, milk 48 hours. See xylazine for drug combination for surgical anesthesia. Levothyroxine Other names: T4, T4 thyroxine sodium, levothryoxin natrium, levothyrocinum natricum. Use: hypothyroidism Dose form: Oral: 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.8, 1.0 mg tablets Dose: Dog 0.022 mg/kg bid PO Note: Perform serum T4 level prior to beginning therapy. Treatment is livelong. Lidocaine Other names: lidocaini hydrochloridum, lignocaine hydrochloride, Xylocaine. Use: Local, regional and topical anesthetic Dose form: Injectible 2% - 50, 100, 250 ml vials Dose: Dog 1.0 ml/kg Horse 15-20 ml/45 kg Bovine 15-20 ml/45 kg Note: Suggested withdrawal for meat and milk 48 hours. 12 | V e t s c r a f t. c o m Oxytetracycline Other names: glomycin, hydroxytetracycline, ocytetracylinium, riomitsin, terrafungine. Use: Broad spectrum antibiotic Dose form: Injectible 100 mg/ml 200 mg/ml (LA-200) Oral tablets 250 mg/tablet Dose: Bovine 5-10 mg/kg IM q24 hr or 20 mg/kg Q48-72hr (LA200) Dogs and cats 20 mg/kg tid Swine, sheep and goats 6-11 mg/kg IV or IM 10-20 mg/kg PO qid Note: Label withdrawal meat 28 days, milk 120 hours. Use of tetracyclines in horses may cause intractable diarrhea. Use only in the last half of pregnancy as use may affect fetal teeth and bones. Do not use in young animals. Oxytocin Other names: alpha-hypophamine, oxytocinum Use: Induction or enhancement of uterine contractions at parturition (OB), postpartum retained placenta (RP), acute postpartum metritis (M), milk let down (MLD). Dose form: Injectible 20 units/ml 100 ml vial Dose: Horse OB: 2.5-5 units q 15-20 minutes until foal is born RP: 20 units IV or IM q 1 hr beginning 2-3 hours after foaling M: 20 units IM tid-qid for 2-3 days Bovine IM, repeat no sooner than 30 minutes if necessary RP: 40-60 units q 2 hrs M: 20 units IM tid-qid for 2-3 days MLD: 10-20 units IV Sheep, goats RP: 10-20 units M: 5--10 units IM tid-qid for 2-3 days Swine MLD: 20-40 units IM tid-qid RP: 20-30 units q 2-3 hours OB: 10 units IM repeat no sooner than 30 minutes if necessary dog OB: 0.5-3 units SQ or IM q30-60 minutes M: 0.5-1 unit/kg IM. May repeat in 1-2 hours. cat OB: 0.25-1 unit SQ or IM q 30-60 minutes Note: 13 | V e t s c r a f t. c o m Penicillin G Procaine Other names: benzylpenicillin, crystalline penicillin G, penicillin, Crystacillin, pen- Aqueous, Microcillin, Pfi-Pen G, Agri-Cillin, Aquacillin Use: Gram positive infections Dose form: Injectible: 300,000 units/ml aqueous suspension, 100 and 250 ml vial Horse 0.7 -0.15ml/kg IM, SQ bid Cattle 0.15-0.22 ml/kg IM, SQ, once daily Swine 0.13 ml/kg IM, SQ, once daily Dog 0.06 ml/kg IM, SQ q 24-48 hours Dose: All species Loading dose 40,000 units/kg IM (14mls/100 kg); then 20,000 units/kg (7 mls/100 kg ) once or twice daily IM Note: Meat withdrawal 30 days, milk 48 hours, slaughter 10 days. Permethrin Other names: Permectrin II Use: External and premise insecticide Dose form: Spray: 11% concentrate, 32 oz bottle Dose: Livestock Use as directed on label Note: Synthetic pyrethrin, good residual activity due to absorption by skin. 14 | V e t s c r a f t. c o m Other names: butadiene, fenibutazona, phenylbutazonum, Phenylbute, Butaject, Butazolidin Use: Anti-inflammatory Dose form: Injectible 200 mg/ml, 100 ml vial Oral 1 gm tablets Oral 12 gm paste Dose: Horse 3.0-6.0 mg/kg IV once daily 4.4-8.8 mg/kg PO once daily 1-2 grams paste once or twice daily* Bovine 2-5 mg/kg IV 4-8 mg/kg PO 2-4 grams paste once or twice daily Ovine 5 mg/kg daily IV or PO Swine 4 mg/kg daily, IV or PO Dog 1-5 mg/kg PO tid, (maximum of 800 mg/day) Note: Horse paste dose is for a 400-500 kg horse- adjust dose for smaller or larger size horses. Discontinue use in horse as soon as significant improvement due to risk of renal damage and gastric ulcers. Give injectible form IV ONLY. Other names: Betadine, Etodine Use: Topical antiseptic Dose form: Topical Solution, surgical scrub Ointment, 0.9 gram packet, 1 lb jar Dose: Note: 15 | V e t s c r a f t. c o m Praziquantel Other names: Droncit Use: cestocide Dose form: Injectible 56.8 mg/ml, 10 ml vial Oral 23 mg tabs (feline) 34 mg tabs (canine) Dose: Dog Dose according to label directions Cat Note: Prednisolone Other names: deltahydrocortisone, metacortadnralone. Use: Corticosteroid therapy, anti-inflammatory Dose form: Oral 5 mg and 20 mg tablets, oral solution Dose: Horse: 1 mg/kg daily before tapering Dog, cat 0.5 – 2.0 mg/kg PO once daily to bid Note: Prednisone Other names: delta(1)-cortisone, 1,2 dehydrocortisone, deltacortisone, deltadehydocortisone, metacortandracin, NSC-10023, prenisonum. Deltasone Use: Corticosteroid therapy, anti-inflammatory Dose form: Oral 5 mg and 20 mg tables, oral solution Dose: Dog, cat 0.5-2.0 mg/kg PO once daily to bid Note: Must taper dose before stopping. Not effective in horses. Sulfadimethoxine Other names: solfadimetossina, solfadimetossptirimidina, sulphadimethoxine, Chemisolfa, Deltin, Risulpir, Ritarsulfa, Sulfadren, Sulfastop, Sulfathox, Albon Use: Long acting antibiotic Dose form: Injectible 400 mg/ml Oral 250 mg tablets Oral 94.6 gm packet Oral 50 mg/ml suspension Dose: All species 55 mg/kg as the first dose then 25 mg/kg daily PO, IV Note: Label withdrawal time meat 28 days, milk 120 hours 16 | V e t s c r a f t. c o m Trimethoprim/sulfadiazine Other names: Co-trimoxazole, SMX-TMP, TMP-SMX, trimethoprim-sulfamethoxazole, sulfamethoxazole-trimethoprim, sulfadiazine-trimethoprim, trimethoprim-sulfadiazine, TMP- SDZ, SDZ-TMP, Co-trimazine, Tribrissen, Use: Potentiated antibiotic Dose form: Oral 480 mg and 960 mg tablets.48 mg/ml oral suspension. Combination product containing one part trimethoprim to 5 parts sulfamethoxazole Dose: horse 15-30 mg/kg bid PO dog 15-30 mg/kg bid PO cat 15-30 mg/kg bid PO Note: Tylosin Other names: Tylan Use: Macrolide antibiotic Dose form: Injectible 200mg/ml Oral powder 25 gm (base)/318.6 gm bottle Dose: pig 8.8 mg/kg IM twice a day Dose: dog 11 mg/kg tid PO (approx. ¼ tsp powder per 4.5kg Note: Vitamin A Use: Nutrition Dose form: Injectible 500,000 IU/ml with Vitamin D3 Dose: 65 IU/kg daily, minimum requirement bovine 2-4 ml, IM Ovine, swine 0.1-2.0 ml IM Note: For vitamin A deficiency in cattle lacking adequate green, leafy forage, or eating hay fertilized recently with nitrogen. 17 | V e t s c r a f t. c o m Vitamin B Complex Use: Nutrition Dose form: Injectible 100 ml vial Dose: Horse 10-20 ml daily IM or IV sheep 3-5 ml/daily IM or IV Bovine 10-20 ml daily IM or IV Swine 2-5 ml daily IM or IV Dog, cat 1-2 ml daily IM or IV Note: Good for neurological problems or in case of deficiency. Vitamin E Other names: d-alpha-tocopheryl Use: Nutrition, antioxidant Dose form: Oral 400 IU capsules, 28,000 IU/oz bottle Dose: horse 1 ml/45 kg IM or IV dog 400 IU once daily for large or medium dogs Note: Follow label directions. Try to get laboratory confirmation of deficiency prior to starting therapy if possible. 18 | V e t s c r a f t. c o m Xylazine Other names: Bay-Va-1470, Rompun, AnaSed, Tranquived, Sedazine, Xyla-ject Use: Sedative, analgesic Dose form: Injectible 20 mg/ml 100 mg/ml Dose: Horse 1-2 mg/kg IM 0.5-1.1 mg/kg IV Bovine, sheep, goats 0.1-0.3 mg/kg IM Sedative dose 0.03 to 0.1 mg/kg IV Swine 2.2 mg/kg IV Dog, cat 1.1-2.2 mg/kg IV IM, SQ Note: Lower doses IV, higher doses IM, SQ. Cattle, sheep, goats are extremely sensitive to Xylazine – use with caution in ruminants. Field anesthesia guidelines for xylazine: Ruminants: Xylazine IM or IV in higher doses than listed above will cause recumbency in ruminants. This is useful to achieve total chemical restraint for surgical or obstetrical procedures. Get ruminant in sternal recumbency as soon as possible or regurgitation or bloat (rumenal tympany) can occur and be fatal. Reverse xylazine with tolazoline or yohimbine if possible. Dogs: Xylazine will often cause vomiting in dogs. This can be useful to empty stomach contents, but be very careful to prevent aspiration. Xylazine causes secondary AV nodal block in dogs. Monitor cardiovascular activity carefully during use in dogs. Have reversal agent (Yohimbine or Tolazoline) and cardiac arrest drug (atropine) available when using in dogs. Horse: To induce short term recumbency/surgical anesthesia in horses: 1-2 mg/kg xylazine IV, wait several minutes until horses’ head is lowered significantly, then give 2-3 mg/kg ketamine IV to induce anesthesia. This combination of drugs will give approximately 15-30 minutes of recumbency, making this an excellent protocol for castration. 19 | V e t s c r a f t. c o m

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