Diazepam Medication Guide PDF

GENERIC NAME diazepam TRADE, BRAND, OR PROPRIETARY NAME Valium® CLASSES Benzodiazepine Anticonvulsant Sedative Hypnotic STANDARD SUPPLIES Vial Ampule MECHANISMS OF ACTION Produces sedation by acting on the limbic system, the thalamus, and hypothalamus Binds to gamma-amino butyric acid (GABA) benzodi...

GENERIC NAME diazepam TRADE, BRAND, OR PROPRIETARY NAME Valium® CLASSES Benzodiazepine Anticonvulsant Sedative Hypnotic STANDARD SUPPLIES Vial Ampule MECHANISMS OF ACTION Produces sedation by acting on the limbic system, the thalamus, and hypothalamus Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain Raises the seizure threshold Produces tranquilizing (antianxiety) effect on the central nervous system INDICATIONS Seizure activity Status epilepticus Procedural sedation for rapid sequence intubation and cardioversion Chemical restraint for agitated (excited) delirium Delirium tremens Severe anxiety CONTRAINDICATIONS Known hypersensitivity to the drug Head injury DIAZEPAM 1 ADVERSE REACTIONS/SIDE EFFECTS Sedation Transient amnesia Respiratory depression Respiratory arrest Bradycardia Hypotension Dizziness Drowsiness Blurred vision Nausea Vomiting ROUTES OF ADMINISTRATION IV IO IM Rectal ONSETS OF ACTION IV/IO: 2 to 5 minutes IM: 15 to 30 minutes Rectal: variable ADULT DOSAGES 2.0 mg increments over 2 minutes PEDIATRIC DOSAGES IV/IO: 0.2 to 0.3 mg/kg IM: 0.1 to 2.0 mg/kg Rectal: 0.2 to 0.5 mg/kg SPECIAL CONSIDERATIONS The peak effect of IV/IO administration of the drug is 15 minutes The peak effect of IM administration of the drug is 30 to 45 minutes The duration of IV/IO administration of the drug is 15 to 60 minutes The duration of IM administration of the drug is 15 to 60 minutes The peak effect of rectal administration of the drug to pediatric patients is variable The duration of rectal administration of the drug to pediatric patients is variable Efficacy of rectal administration of the drug to adults has not been established DIAZEPAM 2