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Cell Cycle Check Point.pdf

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Full Transcript

Cycle Checkpoint Intra-s-phase Checkpoint (SAC) The purpose of this Checkpoint · cells that The key · in mitosis enter player ATR , is entryintoMitosisuntil aDNAhas attached Dothe This checkpoint ensures have been Ensure · * To anaphase make sure chromatids sister completed been CDC25 chromas arenot...

Cycle Checkpoint Intra-s-phase Checkpoint (SAC) The purpose of this Checkpoint · cells that The key · in mitosis enter player ATR , is entryintoMitosisuntil aDNAhas attached Dothe This checkpoint ensures have been Ensure · * To anaphase make sure chromatids sister completed been CDC25 chromas arenotseparatedbefore BubRI , Bub3) of thats binds Conesin , active Kinetochores · Kinetochores · are are a key protein layerofSA centrosomes (DNA) with Tublin connect fibers of the Kittenmanist components are founded many SAC · on It promotes Aneuplodiy , , of one of the hallmarks cancer cells in mutated Cancer damage Response (DDR) DWA This checkpoint Of the in activates presence Damage DNA come can This DNA damage · Apaco, CANCER and : nowbelos is spindlea · · is chromos allchromosomesaveattached Ma,BubRanaBubleaseTobind ApCKwhich once [D WHY all attached still are Saworks through series ofproteins(Mad,a SAC prevent thus and replaa a · · has replication phosphorylates been (SAC) Spindle assembly Checkpoint · prevent is to DNA before kinase that a from : Irradiation · stalled replicationforseeplication & · DamagCheckpointA vide DNA · · Transducers · Effectors The final effect the checkpoint of Tostop cel apair · mechanisms for genes necessary transcribe To into : the DNA damage response · ATM If everything ATR and - regulators Master ATM and ATR · fails ↑ apoptosis of DDR phosphorylate that kinases are serines or threonines followed by Glutamine SQ · · or TQ They usually phosphorylate · · ATR Atm is the regulator the ATM is actived main effector is ATMMediatedbyDD · · · DDR · main effectors It can stop It will CHK1 like the the mavor sensor by absence of one kinases ATRMediatedbDDCase · effectors of DDR in , CHK2 and of presence p53 which will drive the also are cell to CHK1 e of ps3 , CHkl cycle at activate and the , DDR in which PS3 the , and and : presence will DSB and other types 61/S DSB of other can The MRN take of come a complex over its function stalled replication stop replication of DNA DDR stalled forks Arisactivatedbythemain senorofreplicationStand the. · * In main and fork prevent entry into mitosis Damage CHK2 6) /M alter the transcription of a as well as myriad of activating genes and the Intra-s-phase will activate DNA Checkpoint repair mechanisms and the cell Cycle Darre.. · mustofthisparatedcheckpoints recontrove actingovera damage is produced

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