Big Data Biology And Biological Databases (BT2053) PDF

Summary

These lecture notes cover big data biology and biological databases, focusing on metagenomics and other related topics. The document includes a course structure, experimental design, and applications of metagenomics, and illustrates related concepts using diagrams and tables.

Full Transcript

Big Data Biology and Biological Databases (BT2053) 13/10/2024 Course structure Big Data Biology & Biological Databases Omic...

Big Data Biology and Biological Databases (BT2053) 13/10/2024 Course structure Big Data Biology & Biological Databases Omics Electronic Health Records Storage Data Processing and (EHR) Analysis Databases Genomics Bioinformatics Pipelines IEDB Pharmacogenomics Linux OS Mutation Calling TCGA Epigenetics Python CRISPR/Cas9 ENCODE Transcriptomics R NCBI Copy Number Metagenomics Bash KEGG/REACTOME Structural variations Metabolomics cBioPortal Gene expression Proteomics GWAS Metagenomics Ø Metagenomics is the study of the structure and function of entire nucleotide sequences isolated and analyzed from all the organisms (typically microbes) in a bulk sample. Ø Metagenomics is often used to study a specific community of microorganisms, such as those residing on human skin, in the soil or in a water sample. Ø Metagenomics is a discipline that enables the genomic study of uncultured microorganisms. Metagenomics Bacterial Fungal Viral Metagenomics Metagenomics Metagenomics https://www.genome.gov/genetics-glossary/Metagenomics https://www.frontiersin.org/articles/10.3389/fgene.2015.00348/full Metagenomic experiment Biotechnology Bioinformatics https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000667 https://microbialinformaticsj.biomedcentral.com/articles/10.1186/2042-5783-2-3 https://www.nature.com/articles/s41576-019-0113-7 Genome assembly Wikipedia https://www.frontiersin.org/articles/10.3389/fcimb.2012.00104/full https://jgeb.springeropen.com/articles/10.1186/s43141-020-00043-9 Application of Metagenomics https://learn.gencore.bio.nyu.edu/metgenomics/

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