BIOL1XX8 2024 L6 The Pancreas and Diabetes Lecture Notes PDF

18/01/2024 Endocrine regulation: insulin secretion Presented by Professor Peter Thorn, Charles Perkins Centre School of Medical Sciences Thornlab.com OLE Health Challenges: Diabetes OLEO1503 or OLET1504 WARNING This presentation may contain material that has been reproduced and communicated to you b...

18/01/2024 Endocrine regulation: insulin secretion Presented by Professor Peter Thorn, Charles Perkins Centre School of Medical Sciences Thornlab.com OLE Health Challenges: Diabetes OLEO1503 or OLET1504 WARNING This presentation may contain material that has been reproduced and communicated to you by or on behalf of the University of Sydney in accordance with section 113P of the Copyright Act 1968 (Act). The material in this communication may be subject to copyright under the Act. Any further reproduction or communication of this material by you may be the subject of copyright protection under the Act. Do not remove this notice The University of Sydney Page 1 1 Aims Describe the mechanisms that regulate insulin secretion in the pancreas Outline the disease of diabetes and understand the differences between type 1 and type 2 diabetes The University of Sydney Page 2 2 1 18/01/2024 INSULIN Targets: Muscle to promote glucose uptake Liver to promote glycogen storage Fat to promote glucose uptake Amino acids lactate Glucagon Targets: Liver to promote glycogen breakdown ketones and glucose release Free fatty acids glycerol The University of Sydney Page 3 The University of Sydney Page 4 3 4 2 18/01/2024 The University of Sydney Page 5 5 Principles of beta cell function - integration glucose Amino acids Beta cell INSULIN Hormones - etc The University of Sydney Page 6 6 3 18/01/2024 Principles of beta cell function – excitability The University of Sydney Page 7 7 Principles of beta cell function – excitability The University of Sydney Page 8 8 4 18/01/2024 Principles of beta cell function - integration glucose Amino acids Beta cell INSULIN Hormones - etc The University of Sydney Page 9 9 How GLP-1 interacts with the signal cascade controlling insulin secretion The University of Sydney Page 10 10 5 18/01/2024 Aims Describe the mechanisms that regulate insulin secretion in the pancreas Outline the disease of diabetes and understand the differences between type 1 and type 2 diabetes The University of Sydney Page 11 11 Mid-lecture activity 100 mg/dl = 5.5 mM The University of Sydney Page 12 12 6 18/01/2024 T1D symptoms The University of Sydney Page 13 13 T1D cause: autoimmunity The University of Sydney Page 14 14 7 18/01/2024 Treatment: glucose testing and insulin injections The University of Sydney Page 15 15 T1D, continuous glucose monitoring The University of Sydney Page 16 16 8 18/01/2024 T1D, continuous glucose monitoring The University of Sydney Page 17 17 T2D, symptoms The University of Sydney Page 18 18 9 18/01/2024 T2D, reduction in insulin secretion Byetta is a GLP-1 agonist The University of Sydney Page 19 19 T1D vs T2D The University of Sydney Page 20 20 10 18/01/2024 Aims Describe the mechanisms that regulate hormone secretion in the pancreas Outline the disease of diabetes The University of Sydney Page 21 21 11