Basal Ganglia PDF

Basal Ganglia The basal ganglia are among the most complex and least understood structures in the mammalian forebrain ⚪ The definition of basal ganglia is subject to some variation, but key structures include the corpus striatum (Caudate nucleus, putamen and globus pallidus),...

Basal Ganglia The basal ganglia are among the most complex and least understood structures in the mammalian forebrain ⚪ The definition of basal ganglia is subject to some variation, but key structures include the corpus striatum (Caudate nucleus, putamen and globus pallidus), subthalamic nucleus and the substantia nigra. ⚪ Interconnect throught the telencephalon, diencephalon and midbrain. ⚪ The neostriatum consist of the caudate nucleus and putamen ⚪ Separate in primate but united in rodents ⚪ Input of BG ⚪ Globus pallidus 2 segment ⚪ Definition: ⚪ It is a collection of grey matter deeply situated in each cerebral hemisphere. ⚪ They play an important role in the control of posture and voluntary movement. ⚪ They are part of extrapyramidal system. ⚪ Division: ⚪ 1- Corpus striatum: which is divided by internal capsule into: Caudate nucleus & Lentiform Nucleus. 2- Amygdaloid body. 3- Claustrum. ⚪ NB. The subthalamic nucleus (in diencephalon) & Substantia nigra & red nucleus (in midbrain) are functionally in close relation with basal ganglia but they should not be included with them. ⚪ Lies lateral to Thalamus. ⚪ It is divided completely by internal capsule into caudate nucleus and Lentiform nucleus. ⚪ Bands of grey matter pass from lentiform nucleus across the internal capsule to the caudate nucleus, giving the striated appearance hence, the name corpus striatum. ⚪ Large C-shaped or comma-shaped mass of grey matter. ⚪ Lies in close relation to lateral ventricle. ⚪ It has a Head, Body, and Tail. ⚪ Head :( Anterior) Large, & rounded and forms the lateral wall of anterior horn of lateral ventricle. ⚪ It is continuous inferiorly with putamen of lentiform Nucleus. ⚪ Body : Long &narrow continuous with head at the interventricular foramen. ⚪ It forms part of the floor of body of lateral ventricle. ⚪ Tail : Long & narrow, and lies in the roof of inferior horn of lateral ventricle. ⚪ It is connected anteriorly with Amygdaloid nucleus. ⚪ It is a mass of grey matter wedge-shaped or (biconvex lens). ⚪ It has 2 capsules, external capsule laterally & internal capsule medially. ⚪ Internal capsule separates between lentiform nucleus laterally & caudate nucleus and thalamus medially. ⚪ External capsule separates between lentiform nucleus and Claustrum. ⚪ It is divided into Putamen & globus pallidus. ⚪ Putamen :Larger darker lateral portion. ⚪ Globus pallidus : Smaller, lighter medial portion. ⚪ Inferiorly putamen is continuous with the head of caudate nucleus. ⚪ Almond-shaped small mass of grey matter lies in temporal lobe close to the Uncus. ⚪ Lies Anterosuperior to inferior horn of lateral ventricle. ⚪ It is connected to the tail of caudate nucleus. ⚪ It is the smell center & part of limbic system. ⚪ Claustrum: ⚪ Thin sheet of gray matter which lies lateral to external capsule & medial to the Insula.  Connection Of Corpus Striatum ⚪ Afferent Fibers ( Input): ⚪ I- Corticostriate Fibers: From all parts of cerebral cortex (mostly from sensory- motor cortex) axons pass to caudate nucleus and putamen. ⚪ Glutamate is the neurotransmitter of this fibers. ⚪ II-Thalamostriate Fibers : From intralaminar nuclei of thalamus axons pass to caudate nucleus and putamen. ⚪ III- Nigrostriate Fibers : Axons from Substantia nigra of midbrain pass to caudate nucleus and putamen. ⚪ Neurotransmitter is Dopamine. IV_Brain stem Strial Fibers : Ascending fibers from brain stem end in caudate nucleus & putamen. ⚪ Serotonin is the neurotransmitter. ⚪ It is believed that the last 2 groups are inhibitory in function ⚪ Efferent fibers (Output): ⚪ 1-Striatopallidal fibers: ⚪ These fibers pass from corpus striatum (caudate nucleus & putamen) to globus pallidus. ⚪ Gamma-aminobutyric acid (GABA) is the neurotransmitter. ⚪ 2-Striatonigral fibers: ⚪ These fibers pass from caudate nucleus & putamen to Substantia nigra. ⚪ Some fibers use GABA as a neurotransmitter, and others use substance p.  Introduction to function of basal Nuclei Basically the activity of basal nuclei begins by information received from sensory cortex, thalamus, substantia nigra, and red nucleus, according to thoughts of mind. ⚪ These information is integrated within corpus striatum and channeled within globus pallidus and outflow back to motor areas of cerebral cortex, and other motor areas in brain stem. ⚪ Thus the basal nuclei can control muscular movement through its effect on cerebral cortex ⚪ So basal nuclei assist in regulation of voluntary movement and learning of motor skills. ⚪ Functions of basal ganglia: ⚪ 1- Design of plans, which convert thoughts and ideas into motor actions: to produce a coordinated organized purposeful movement. e.g. dressing. ⚪ Determining the timing and scale of movement: to what extent the movement will be fast, and how long it will last. ⚪ Storage of motor programs of familiar motor actions: e.g. signature.  Manifestation of lesion of basal ganglia ⚪ I- Involuntary movement during rest: Chorea, athetosis, hemiballismus, and tremor. ⚪ II- Changes in muscle tone. ⚪ A- Chorea: (Dance). Lesion: in caudate N ⚪ Features: Involuntary, quick, Jerky, irregular, nonrepetitive and purposeless movement : e.g. Swift grimaces, and sudden movement of head or limb. Types: Sydenham (rheumatic fiver) more in female, Huntington’s, (hereditary), chorea Gravidarum, or chorea of contraceptive pills. Huntington’s Chorea ⚪ Athetosis: (Greek= Not fixed). ⚪ Lesion: Putamen & Globus pallidus. ⚪ Features: Involuntary, slow, sinuous, writhing movements involving distal part of limb (hand). ⚪ Hemiballismus: (Greek= Jumping) Lesion: Subthalamus Features: Sudden, involuntary, spasmodic movements that involves one limb or one side of the body (Limb suddenly flies about in all directions out of control)  Parkinsonism Parkinson’s disease, paralysis Agitans ⚪ Lesion: Neuronal degeneration in substantia nigra leading to reduction of dopamine within corpus striatum. ⚪ Features: 1- Tremors: Pill-rolling, involuntary, rhythmic, oscillating movements. It occurs during waking time during rest, it is called static tremors. 2- Rigidity: It occurs in both flexors, and extensors, but more in flexors giving flexion attitude. It is called lead pipe rigidity. 3- Akinesia: it means lack of movement; Absence of swinging arm during walking, mask face, low- volume slow monotonous speech, and shuffling gait. Parkinsonism