اتشبتر الأمين 27.pdf

Mahmoud Abdelaziz Chemistry 0523746180 1 Mahmoud Abdelaziz Chemistry 0523746180 2 Mahmoud Abdelaziz Chemistry 0523746180 3 Mahmoud Abdelaziz Chemistry 0523746180 4 Mahmoud Abdelazi...

Mahmoud Abdelaziz Chemistry 0523746180 1 Mahmoud Abdelaziz Chemistry 0523746180 2 Mahmoud Abdelaziz Chemistry 0523746180 3 Mahmoud Abdelaziz Chemistry 0523746180 4 Mahmoud Abdelaziz Chemistry 0523746180 5 Mahmoud Abdelaziz Chemistry 0523746180 6 Mahmoud Abdelaziz Chemistry 0523746180 7 Mahmoud Abdelaziz Chemistry 0523746180 8 Mahmoud Abdelaziz Chemistry 0523746180 9 Mahmoud Abdelaziz Chemistry 0523746180 10 Mahmoud Abdelaziz Chemistry 0523746180 11 Mahmoud Abdelaziz Chemistry 0523746180 12 Mahmoud Abdelaziz Chemistry 0523746180 13 Mahmoud Abdelaziz Chemistry 0523746180 14 Mahmoud Abdelaziz Chemistry 0523746180 15 Mahmoud Abdelaziz Chemistry 0523746180 16 Mahmoud Abdelaziz Chemistry 0523746180 17 Mahmoud Abdelaziz Chemistry 0523746180 18 Mahmoud Abdelaziz Chemistry 0523746180 19 Mahmoud Abdelaziz Chemistry 0523746180 20 Mahmoud Abdelaziz Chemistry 0523746180 21 Mahmoud Abdelaziz Chemistry 0523746180 22 Mahmoud Abdelaziz Chemistry 0523746180 Acylation-Reduction An acid chloride reacts with ammonia or a 1 amine or a 2 amine to form an amide.   The C=O of the amide is reduced to CH with lithium aluminum hydride. 2 Ammonia yields a 1 amine. A 1 amine yields a 2 amine.   A 2 amine yields a 3 amine. primary amine tertiary amine Direct Alkylation (1) Use a large excess (10:1) of ammonia with a primary alkyl halide or tosylate. Reaction mechanism is S 2. N NH3 CH3CH2CH2 Br CH3CH2CH2 NH2 + NH4Br 23 Mahmoud Abdelaziz Chemistry 0523746180 24 Mahmoud Abdelaziz Chemistry 0523746180 Gabriel Synthesis (1) 25 Mahmoud Abdelaziz Chemistry 0523746180 26 Mahmoud Abdelaziz Chemistry 0523746180 27 Mahmoud Abdelaziz Chemistry 0523746180 28 Mahmoud Abdelaziz Chemistry 0523746180 29 Mahmoud Abdelaziz Chemistry 0523746180 Exam 1. Cl2. NaOH-H2O 2. NaBH4 3. LiAlH4 4. KMnO4 Which of the following amines is most soluble in water? B) PhNH2 A) pyrrolidine E) ethylamine D) (CH3CH2CH2)2NH C) (CH3)3N 30 Mahmoud Abdelaziz Chemistry 0523746180 Secondary amines react with the nitrosonium ion to generate: E) anilines C) N-nitrosoamines D) imines A) diazonium salts B) oximes Which of the following is a secondary amine? B) 3-pentanamine C) methylamine E) N-ethyl-1-propanamine D) N,N-dimethylaniline A) cyclohexylamine Physostigmine is used in the treatment of glaucoma. Within this structure, the atom indicated by __________ is most basic, while atom __________ is least basic A) 1 (most basic), 4 (least basic) B) 1 (most basic), 3 (least basic) C) 2 (most basic), 4 (least basic) D) 2 (most basic), 3 (least basic) E) None of the above 31 Mahmoud Abdelaziz Chemistry 0523746180 LiAlH4 1- HNO2, 2- H3O+ 1- HNO2, H3PO4 1- HNO2, H3PO2 32 Mahmoud Abdelaziz Chemistry 0523746180 33