Adaptive Immunity B Cells PDF

1 11 51 sina.aesmanecurn.itases Type11 Diabetes Alzheimer's Crowns Hepatitis Cardiovascular disease Liver cancer InnateImmune System provides signals to produce antibodies and T cells of the adaptive response...

1 11 51 sina.aesmanecurn.itases Type11 Diabetes Alzheimer's Crowns Hepatitis Cardiovascular disease Liver cancer InnateImmune System provides signals to produce antibodies and T cells of the adaptive response 2Types of Immunological Recognition cell mediated Immunity Humoral Immunity T cells response Bcell response is soluble link to clonal doesn't need sediment selection expansion or cells involves receptors bound to surface of T lymphocytes Immunoglobulins Secreted by B lymphocytes and are called antibodies keydifference Antibodies target pathogens Bcell immunity T cell Receptors target infected cells tall immunity  regions 99 us ondfvariable II constant regions keypoint Variable regions bind antigens Constant regions definefunction Immunoglobulins genes have repealquences repeatgilns code8 mTit onlysome used to make me immunoglobulins tep tᵗ sequences are selected bygene rearrangment 1ˢᵗGene Rearrangement Select diversity joining regions added to constant region 2ⁿᵈ Gene Rearrangement selects the variable region rearranged immunoglobulin genesencode MRNA to make antibody protein Link Tcell mediated immunity is very important for B cell help in anti viral immunity Tcell receptors are not immunoglobulins but they do resemble them only expressed in T cells Summary oflink betweenGene Rearrangement Adaptive ImmunityB 1 Gene rearrangement only takes place in B T cells 2 Allows you to acquire an immune response 3 Allows your immune system to adapt Tand B cells at random but each cell rearrange can only rearrange genes once IIIIffment occurs the cells that have rearranged the right segments bind toantigens Antigen binding triggers cell division  111 2 B cells proliferate 1 1 15 bind to Bous diff into plasma cells that release specific antibodies HEh.tt cannot make right antibodies because HIV kills Helper Tcells Keyfpoint T cells don't recognise antigens directly but instead recognise infected cells Thelpercells seeantigens on APC's of innate immune system they proliferate when they see an antigen Dendritic cells Macrophagespresent antigens to helper T cells Tells know when to provide help because if the Bcell needs help it becomes an APC so Tall recognises  it 1 B cell presents antigen T cell 2 B cell only gets help T cell agrees that the B if Cell has presented an antigen this prevents self reactive antibodies 8 Autoimmune diseases look at last few slides for revision but not examined Watch recording part where he link describes between B cells Tells